ENSDARG00000012196


Danio rerio

Features
Gene ID: ENSDARG00000012196
  
Biological name :fer
  
Synonyms : fer / fer (fps/fes related) tyrosine kinase
  
Possible biological names infered from orthology : FER tyrosine kinase / P16591 / P70451 / Tyrosine-protein kinase Fer
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 57243568
Gene end: 57311037
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000155466
Ensembl peptide - ENSDARP00000050956
Ensembl peptide - ENSDARP00000124066
NCBI entrez gene - 565199     See in Manteia.
swissprot - F1QBS0
swissprot - F8W3J0
ZFIN ID - ZDB-GENE-060526-234
Ensembl - ENSDARG00000012196
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FERENSGALG00000000273Gallus gallus
 FERENSG00000151422Homo sapiens
 FerENSMUSG00000000127Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fes / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *ENSDARG0000001144948
itk / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *ENSDARG0000001756522
abl2 / c-abl oncogene 2, non-receptor tyrosine kinase / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSDARG0000001384121
abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSDARG0000003518721
btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *ENSDARG0000000443320
tec / tec protein tyrosine kinase / P42680*ENSDARG0000009847719
csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *ENSDARG0000006799617
matk / megakaryocyte-associated tyrosine kinase / P42679*ENSDARG0000007467017
txk / TXK tyrosine kinase / P42681*ENSDARG0000001506812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001060  FCH domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016250  Tyrosine-protein kinase, Fes/Fps type
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027267  AH/BAR domain superfamily
 IPR028539  Tyrosine-protein kinase Fer
 IPR031160  F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006935 chemotaxis IBA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043304 regulation of mast cell degranulation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye far from eye , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000737 cranium cranium malformed , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage malformed , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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