ENSDARG00000011449


Danio rerio

Features
Gene ID: ENSDARG00000011449
  
Biological name :fes
  
Synonyms : fes / FES proto-oncogene, tyrosine kinase
  
Possible biological names infered from orthology : P07332 / P16879 / Tyrosine-protein kinase Fes/Fps
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 14211322
Gene end: 14266466
  
Corresponding Affymetrix probe sets: Dr.13023.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000147268
Ensembl peptide - ENSDARP00000124270
Ensembl peptide - ENSDARP00000123707
NCBI entrez gene - 566739     See in Manteia.
RefSeq - NM_001199869
RefSeq - XM_005166383
RefSeq Peptide - NP_001186798
swissprot - F8W5D1
swissprot - F8W425
ZFIN ID - ZDB-GENE-100812-10
Ensembl - ENSDARG00000011449
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FESENSGALG00000008340Gallus gallus
 FESENSG00000182511Homo sapiens
 FesENSMUSG00000053158Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fer / fer (fps/fes related) tyrosine kinase / P70451* / P16591* / FER tyrosine kinase* / Tyrosine-protein kinase Fer *ENSDARG0000001219650
itk / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *ENSDARG0000001756521
abl2 / c-abl oncogene 2, non-receptor tyrosine kinase / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSDARG0000001384120
abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSDARG0000003518720
btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *ENSDARG0000000443319
csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *ENSDARG0000006799617
matk / megakaryocyte-associated tyrosine kinase / P42679*ENSDARG0000007467017
tec / tec protein tyrosine kinase / P42680*ENSDARG0000009847717
txk / TXK tyrosine kinase / P42681*ENSDARG0000001506812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001060  FCH domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016250  Tyrosine-protein kinase, Fes/Fps type
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / complex / reaction
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / complex
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / complex / reaction






 

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