ENSDARG00000102153


Danio rerio

Features
Gene ID: ENSDARG00000102153
  
Biological name :nrp1a
  
Synonyms : neuropilin 1a / nrp1a
  
Possible biological names infered from orthology : neuropilin 1 / NRP1 / O14786 / P97333
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 1162325
Gene end: 1356668
  
Corresponding Affymetrix probe sets: Dr.23740.1.A1_at (Zebrafish Array)   Dr.26440.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000141420
Ensembl peptide - ENSDARP00000153812
Ensembl peptide - ENSDARP00000148903
Ensembl peptide - ENSDARP00000134467
Ensembl peptide - ENSDARP00000140030
Ensembl peptide - ENSDARP00000140900
NCBI entrez gene - 353246     See in Manteia.
RefSeq - NM_181497
RefSeq - NM_001040326
RefSeq Peptide - NP_001035416
RefSeq Peptide - NP_852474
swissprot - A0A0R4IVS1
swissprot - A0A0R4IFP8
swissprot - F1QXE5
swissprot - Q1RLY9
ZFIN ID - ZDB-GENE-030519-2
Ensembl - ENSDARG00000102153
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NRP1ENSGALG00000007140Gallus gallus
 NRP1ENSG00000099250Homo sapiens
 Nrp1ENSMUSG00000025810Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nrp2b / neuropilin 2bENSDARG0000003844643
nrp2a / neuropilin 2aENSDARG0000009654643
nrp1b / neuropilin 1bENSDARG0000002729035
f5 / coagulation factor V / O88783* / P12259* / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain*ENSDARG0000005570516
f8 / coagulation factor VIII, procoagulant component / P00451* / Q06194* / coagulation factor VIII*ENSDARG0000010138516
mfge8a / milk fat globule-EGF factor 8 protein aENSDARG0000001534913
mfge8b / milk fat globule-EGF factor 8 protein bENSDARG0000004580313
edil3b / EGF-like repeats and discoidin I-like domains 3b / EDIL3* / O35474* / O43854* / EGF like repeats and discoidin domains 3* / EGF-like repeat and discoidin I-like domain-containing protein 3 *ENSDARG0000006087713
edil3a / EGF-like repeats and discoidin I-like domains 3a / EDIL3* / O35474* / O43854* / EGF like repeats and discoidin domains 3* / EGF-like repeat and discoidin I-like domain-containing protein 3 *ENSDARG0000009341313
dcbld2 / discoidin, CUB and LCCL domain containing 2 / Q91ZV3* / Q96PD2* / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA.*ENSDARG0000006217711
dcbld1 / discoidin, CUB and LCCL domain containing 1 / Q8N8Z6* / Q9D4J3* / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA.*ENSDARG000000159079
si:dkey-34d22.1ENSDARG000001031818
hephl1b / hephaestin-like 1b / HEPH* / Q9BQS7* / Q9Z0Z4* / hephaestin*ENSDARG000000264036
rs1a / retinoschisin 1a / RS1* / Q9Z1L4* / O15537* / retinoschisin 1* / retinoschisis (X-linked, juvenile) 1 (human)*ENSDARG000000272366
hephl1a / hephaestin-like 1aENSDARG000000592316
cp / ceruloplasminENSDARG000000103125


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000859  CUB domain
 IPR000998  MAM domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014648  Neuropilin
 IPR022579  Neuropilin, C-terminal
 IPR027146  Neuropilin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035767 endothelial cell chemotaxis IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Signal transduction by L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite U-shaped , abnormal
Show

 ZFA:0000186 common cardinal vein common cardinal vein blood vessel endothelium patchy , abnormal
common cardinal vein cell-cell junction decreased length , abnormal
common cardinal vein actin filament bundle disoriented , abnormal
common cardinal vein actin filament bundle organization decreased process quality , abnormal
common cardinal vein blood vessel endothelial cell structure, cavities , abnormal
Show

 ZFA:0000213 habenula habenula axon misrouted , abnormal
Show

 ZFA:0000903 interpeduncular nucleus tegmentum interpeduncular nucleus tegmentum structure , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon truncated , abnormal
motor neuron axon branchiness , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron axon decreased length , abnormal
CaP motoneuron axon branched , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / complex
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / complex / reaction
 ENSDARG00000045087 cdk5r1b / cyclin-dependent kinase 5, regulatory subunit 1b (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000056683 cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *  / complex
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction
 ENSDARG00000037916 cdk5r1a / cyclin-dependent kinase 5, regulatory subunit 1a (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000016429 farp2 / FERM, RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARH/RhoGEF and pleckstrin domain protein 2* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *  / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000011449 fes / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / complex
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex / reaction
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr