ENSDARG00000016429


Danio rerio

Features
Gene ID: ENSDARG00000016429
  
Biological name :farp2
  
Synonyms : farp2 / FERM, RhoGEF and pleckstrin domain protein 2
  
Possible biological names infered from orthology : FERM, ARHGEF and pleckstrin domain-containing protein 2 / FERM, ARH/RhoGEF and pleckstrin domain protein 2 / O94887 / Q91VS8
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 26948093
Gene end: 27038629
  
Corresponding Affymetrix probe sets: Dr.12847.1.A1_at (Zebrafish Array)   Dr.5587.1.A1_at (Zebrafish Array)   Dr.5587.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000129105
Ensembl peptide - ENSDARP00000129410
NCBI entrez gene - 567490     See in Manteia.
RefSeq - XM_009302421
RefSeq - XM_021477115
swissprot - X1WFV0
swissprot - E7FE33
ZFIN ID - ZDB-GENE-030131-2993
Ensembl - ENSDARG00000016429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FARP2ENSGALG00000005788Gallus gallus
 FARP2ENSG00000006607Homo sapiens
 Farp2ENSMUSG00000034066Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
farp1 / FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) / Q9Y4F1* / F8VPU2* / FERM, ARH/RhoGEF and pleckstrin domain protein 1* / FERM, ARHGEF and pleckstrin dom...ENSDARG0000007438154
frmd7 / FERM domain containing 7 / A2AD83* / Q6ZUT3* / FERM domain-containing protein 7 *ENSDARG0000006895819
si:ch211-243g6.3 / FRMD7* / A2AD83* / Q6ZUT3* / FERM domain containing 7* / FERM domain-containing protein 7 *ENSDARG0000007049516
ezra / ezrin a / EZR* / ezrin* / P15311* / P26040*ENSDARG0000002094414
msna / moesin a / MSN* / moesin* / P26038* / P26041*ENSDARG0000005812814
ezrb / sytl3 / synaptotagmin-like 3 / EZR* / ezrin* / P15311* / P26040*ENSDARG0000002509113
msnb / moesin b / MSN* / moesin* / P26038* / P26041*ENSDARG0000002874013
nf2a / neurofibromin 2a (merlin) / NF2* / P35240* / P46662* / Merlin * / neurofibromin 2*ENSDARG0000002020412
nf2b / neurofibromin 2b (merlin)ENSDARG0000002556712
mylipa / Q6TEM9 / myosin regulatory light chain interacting protein a / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*ENSDARG0000000885910
mylipb / myosin regulatory light chain interacting protein b / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*ENSDARG000000551189
CABZ01066921.1ENSDARG000001120569


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA


Pathways (from Reactome)
Pathway description
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / complex
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000076001 pip5k1ca / phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a / O60331* / O70161* / PIP5K1C* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*  / complex / reaction
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / reaction
 ENSDARG00000100313 pip5k1cb / phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b / O60331* / O70161* / PIP5K1C* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr