ENSDARG00000025091


Danio rerio

Features
Gene ID: ENSDARG00000025091
  
Biological name :sytl3
  
Synonyms : ezrb / synaptotagmin-like 3 / sytl3
  
Possible biological names infered from orthology : EZR / ezrin / P15311 / P26040
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 13564931
Gene end: 13625588
  
Corresponding Affymetrix probe sets: Dr.17071.1.A1_at (Zebrafish Array)   Dr.21433.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000063817
Ensembl peptide - ENSDARP00000073352
Ensembl peptide - ENSDARP00000126624
Ensembl peptide - ENSDARP00000126801
NCBI entrez gene - 561589     See in Manteia.
RefSeq - NM_001030285
RefSeq Peptide - NP_001025456
swissprot - Q5TZG5
swissprot - F1R321
swissprot - R4GE88
swissprot - R4GDR8
ZFIN ID - ZDB-GENE-040724-150
ZFIN ID - ZDB-GENE-050803-1
Ensembl - ENSDARG00000025091
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EZRENSGALG00000013742Gallus gallus
 EZRENSG00000092820Homo sapiens
 EzrENSMUSG00000052397Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ezra / ezrin a / EZR* / ezrin* / P15311* / P26040*ENSDARG0000002094480
msna / moesin a / MSN* / moesin* / P26038* / P26041*ENSDARG0000005812872
msnb / moesin b / MSN* / moesin* / P26038* / P26041*ENSDARG0000002874068
nf2a / neurofibromin 2a (merlin) / NF2* / P35240* / P46662* / Merlin * / neurofibromin 2*ENSDARG0000002020445
nf2b / neurofibromin 2b (merlin)ENSDARG0000002556743
farp2 / FERM, RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARH/RhoGEF and pleckstrin domain protein 2* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *ENSDARG0000001642924
farp1 / FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) / Q9Y4F1* / F8VPU2* / FERM, ARH/RhoGEF and pleckstrin domain protein 1* / FERM, ARHGEF and pleckstrin dom...ENSDARG0000007438124
frmd7 / FERM domain containing 7 / A2AD83* / Q6ZUT3* / FERM domain-containing protein 7 *ENSDARG0000006895815
mylipa / Q6TEM9 / myosin regulatory light chain interacting protein a / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*ENSDARG0000000885914
mylipb / myosin regulatory light chain interacting protein b / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*ENSDARG0000005511814
si:ch211-243g6.3 / FRMD7* / A2AD83* / Q6ZUT3* / FERM domain containing 7* / FERM domain-containing protein 7 *ENSDARG0000007049513
CABZ01066921.1ENSDARG0000011205611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR008954  Moesin tail domain superfamily
 IPR011174  Ezrin/radixin/moesin
 IPR011259  Ezrin/radixin/moesin, C-terminal
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0035850 epithelial cell differentiation involved in kidney development IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0060271 cilium assembly IGI
 biological_processGO:0090504 epiboly IMP
 biological_processGO:1902017 regulation of cilium assembly IMP
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Recycling pathway of L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000004 anterior axial hypoblast anterior axial hypoblast lamellipodium decreased amount , abnormal
anterior axial hypoblast filopodium decreased amount , abnormal
anterior axial hypoblast bleb increased amount , abnormal
anterior axial hypoblast bleb increased size , abnormal
anterior axial hypoblast decreased cellular motility , abnormal
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 ZFA:0000008 brain brain hydrocephalic , abnormal
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 ZFA:0000150 pronephric duct pronephric duct has fewer parts of type pronephric duct motile cilium, abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate mislocalised , abnormal
pronephric duct 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate mislocalised , abnormal
pronephric duct apical plasma membrane mislocalised , abnormal
pronephric duct filamentous actin mislocalised , abnormal
pronephric duct ciliary basal body mislocalised , abnormal
pronephric duct cilium assembly decreased occurrence , abnormal
pronephric duct actin filament bundle distribution decreased process quality , abnormal
pronephric duct ciliary basal body-plasma membrane docking decreased process quality , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
pronephros cilium assembly decreased process quality , abnormal
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 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
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 ZFA:0001176 blastoderm blastoderm increased thickness , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus cystic , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule has fewer parts of type pronephric tubule microvillus, abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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