ENSGALG00000000273


Gallus gallus

Features
Gene ID: ENSGALG00000000273
  
Biological name :FER
  
Synonyms : FER / FER tyrosine kinase
  
Possible biological names infered from orthology : P16591 / P70451 / Tyrosine-protein kinase Fer
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 47508617
Gene end: 47596423
  
Corresponding Affymetrix probe sets: Gga.2822.1.S1_s_at (Chicken Array)   GgaAffx.25437.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000358
NCBI entrez gene - 415614     See in Manteia.
RefSeq - XM_413981
swissprot - E1C7Z1
Ensembl - ENSGALG00000000273
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ferENSDARG00000012196Danio rerio
 FERENSG00000151422Homo sapiens
 FerENSMUSG00000000127Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *ENSGALG0000000834046
BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *ENSGALG0000000495815
ITK / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *ENSGALG0000000385714
TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*ENSGALG0000001412413
BMX / BMX non-receptor tyrosine kinase / P51813* / P97504* / Cytoplasmic tyrosine-protein kinase BMX *ENSGALG0000001655713
TXK / TXK tyrosine kinase / P42681* / P42682*ENSGALG0000001412712
ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*ENSGALG0000000387511
ABL2* / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSGALG0000003035711
CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*ENSGALG0000003127011
MATK / megakaryocyte-associated tyrosine kinase / P42679*ENSGALG000000007368


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001060  FCH domain
 IPR028539  Tyrosine-protein kinase Fer
 IPR031160  F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010591 regulation of lamellipodium assembly IEA
 biological_processGO:0010762 regulation of fibroblast migration IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033007 negative regulation of mast cell activation involved in immune response IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035426 extracellular matrix-cell signaling IEA
 biological_processGO:0036006 cellular response to macrophage colony-stimulating factor stimulus IEA
 biological_processGO:0036119 response to platelet-derived growth factor IEA
 biological_processGO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway IEA
 biological_processGO:0038109 Kit signaling pathway IEA
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043304 regulation of mast cell degranulation IBA
 biological_processGO:0044331 cell-cell adhesion mediated by cadherin IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0050904 diapedesis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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