ENSGALG00000014127


Gallus gallus

Features
Gene ID: ENSGALG00000014127
  
Biological name :TXK
  
Synonyms : TXK / TXK tyrosine kinase
  
Possible biological names infered from orthology : P42681 / P42682
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 66975729
Gene end: 66988120
  
Corresponding Affymetrix probe sets: GgaAffx.8960.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000022821
NCBI entrez gene - 770387     See in Manteia.
RefSeq - XM_001233721
RefSeq - XM_004936052
swissprot - E1C035
Ensembl - ENSGALG00000014127
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txkENSDARG00000015068Danio rerio
 TXKENSG00000074966Homo sapiens
 TxkENSMUSG00000054892Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*ENSGALG0000001412457
ITK / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *ENSGALG0000000385751
BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *ENSGALG0000000495851
BMX / BMX non-receptor tyrosine kinase / P51813* / P97504* / Cytoplasmic tyrosine-protein kinase BMX *ENSGALG0000001655742
ABL2* / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSGALG0000003035734
ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*ENSGALG0000000387533
CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*ENSGALG0000003127031
FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *ENSGALG0000000834028
MATK / megakaryocyte-associated tyrosine kinase / P42679*ENSGALG0000000073627
FER / FER tyrosine kinase / P16591* / P70451* / Tyrosine-protein kinase Fer *ENSGALG0000000027314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007229 integrin-mediated signaling pathway IBA
 biological_processGO:0010543 regulation of platelet activation IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042246 tissue regeneration IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001012 RNA polymerase II regulatory region DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
FCERI mediated Ca+2 mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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