ENSDARG00000077226


Danio rerio

Features
Gene ID: ENSDARG00000077226
  
Biological name :smarca4a
  
Synonyms : smarca4a / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a
  
Possible biological names infered from orthology : P51532 / Q3TKT4 / SMARCA4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 19245804
Gene end: 19282525
  
Corresponding Affymetrix probe sets: Dr.2414.1.S1_at (Zebrafish Array)   Dr.2414.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000120295
Ensembl peptide - ENSDARP00000143385
NCBI entrez gene - 353295     See in Manteia.
RefSeq - XM_021469728
RefSeq Peptide - NP_853634
swissprot - Q7ZSY3
ZFIN ID - ZDB-GENE-030605-1
Ensembl - ENSDARG00000077226
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P51532ENSG00000127616Homo sapiens
 Q3TKT4ENSMUSG00000032187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMARCA4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 / P51532*ENSDARG0000010433979
smarca2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 / P51531*ENSDARG0000000890472
si:dkey-226m8.10ENSDARG000000605787


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001487  Bromodomain
 IPR001650  Helicase, C-terminal
 IPR006576  BRK domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014012  Helicase/SANT-associated domain
 IPR014978  Glutamine-Leucine-Glutamine, QLQ
 IPR018359  Bromodomain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029295  Snf2, ATP coupling domain
 IPR030100  SWI/SNF complex subunit BRG1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003406 retinal pigment epithelium development IMP
 biological_processGO:0003407 neural retina development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0021634 optic nerve formation IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0043044 ATP-dependent chromatin remodeling IEA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IMP
 biological_processGO:0060038 cardiac muscle cell proliferation IMP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 biological_processGO:0060973 cell migration involved in heart development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016514 SWI/SNF complex IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016817 hydrolase activity, acting on acid anhydrides IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042393 histone binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
Formation of the beta-catenin:TCF transactivating complex
RMTs methylate histone arginines
Chromatin modifying enzymes
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000046 retinal neural layer retinal neural layer absent , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye quality , abnormal
eye decreased size , abnormal
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 ZFA:0000108 fin fin morphology , abnormal
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 ZFA:0000114 heart heart morphology , abnormal
heart malformed , abnormal
heart constricted , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium broken , abnormal
retinal pigmented epithelium decreased pigmentation , abnormal
retinal pigmented epithelium melanosome localization process quality , abnormal
retinal pigmented epithelium melanosome displaced , abnormal
retinal pigmented epithelium cell has fewer parts of type retinal pigmented epithelium melanosome, abnormal
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 ZFA:0000152 retina retina morphology , abnormal
retina dystrophic , abnormal
retina structure , abnormal
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 ZFA:0000217 inner ear inner ear morphology , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II aplastic , abnormal
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 ZFA:0001094 whole organism whole organism movement behavioral quality , abnormal
whole organism decreased pigmentation , abnormal
whole organism viability , abnormal
whole organism curved ventral , abnormal
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 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
post-vent region curved lateral , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Meckels cartilage absent , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch decreased amount , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal increased length , abnormal
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 ZFA:0001321 neurocranial trabecula neurocranial trabecula morphology , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased size , abnormal
palatoquadrate cartilage absent , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage absent , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage absent , abnormal
ethmoid cartilage morphology , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage absent , abnormal
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 ZFA:0001423 parachordal cartilage parachordal cartilage decreased size , abnormal
parachordal cartilage absent , abnormal
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 ZFA:0001510 basihyal cartilage basihyal cartilage absent , abnormal
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 ZFA:0001517 ceratobranchial 2 cartilage ceratobranchial 2 cartilage absent , abnormal
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 ZFA:0001518 ceratobranchial 3 cartilage ceratobranchial 3 cartilage absent , abnormal
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 ZFA:0001519 ceratobranchial 4 cartilage ceratobranchial 4 cartilage absent , abnormal
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 ZFA:0001520 ceratobranchial 1 cartilage ceratobranchial 1 cartilage absent , abnormal
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 ZFA:0001521 ceratobranchial 5 cartilage ceratobranchial 5 cartilage absent , abnormal
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 ZFA:0001580 neurocranium neurocranium morphology , abnormal
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 ZFA:0001609 pharyngeal arch 6 pharyngeal arch 6 absent , abnormal
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 ZFA:0001610 pharyngeal arch 7 pharyngeal arch 7 absent , abnormal
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 ZFA:0009091 melanocyte melanocyte morphology , abnormal
melanocyte decreased amount , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex / reaction
 ENSDARG00000031894 lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*  / complex / reaction
 ENSDARG00000033647 Q5U379 / smarcb1a / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a / Q9Z0H3* / Q12824* / SMARCB1* / SWI/SNF related, matrix associated, a...  / complex
 ENSDARG00000077946 smarcc2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 / Q6PDG5* / Q8TAQ2* / SWI/SNF complex subunit SMARCC2 *  / complex
 ENSDARG00000017397 smarcc1a / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a / P97496* / Q92922* / SMARCC1* / SWI/SNF related, matrix associated, actin depe...  / complex
 ENSDARG00000087646 runx1 / runt-related transcription factor 1 / Q01196*  / complex / reaction






 

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