Manteia

ENSDARG00000020201

Danio rerio

Features

Gene ID:	ENSDARG00000020201

Biological name :	cdc73

Synonyms :	cdc73 / cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

Possible biological names infered from orthology :	cell division cycle 73 / Parafibromin / Q6P1J9 / Q8JZM7

Species:	Danio rerio

Chr. number:	2
Strand:	1
Band:
Gene start:	11946554
Gene end:	12003175

Corresponding Affymetrix probe sets:	Dr.25413.1.A1_at (Zebrafish Array) Dr.6246.1.S1_at (Zebrafish Array) NM_200348_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000017639 Ensembl peptide - ENSDARP00000129750 NCBI entrez gene - 393319 See in Manteia. RefSeq - NM_001291396 RefSeq - NM_200348 RefSeq Peptide - NP_001278325 RefSeq Peptide - NP_956642 swissprot - Q7T3D4 swissprot - X1WHN7 ZFIN ID - ZDB-GENE-040426-1309 Ensembl - ENSDARG00000020201

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR007852	Cdc73/Parafibromin
IPR031336	Cell division control protein 73, C-terminal
IPR032041	Paf1 complex subunit Cdc73, N-terminal domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006368	transcription elongation from RNA polymerase II promoter	IEA
biological_process	GO:0007507	heart development	IMP
biological_process	GO:0016570	histone modification	IBA
biological_process	GO:0021529	spinal cord oligodendrocyte cell differentiation	IMP
biological_process	GO:0030218	erythrocyte differentiation	IGI
biological_process	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IBA
biological_process	GO:0034243	regulation of transcription elongation from RNA polymerase II promoter	IGI
biological_process	GO:0034402	recruitment of 3"-end processing factors to RNA polymerase II holoenzyme complex	IBA
biological_process	GO:0051301	cell division	IEA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0016593	Cdc73/Paf1 complex	IDA
molecular_function	GO:0000993	RNA polymerase II core binding	IBA
molecular_function	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding	IBA

Pathways (from Reactome)

Pathway description

Formation of RNA Pol II elongation complex

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000075	spinal cord	spinal cord oligodendrocyte decreased amount , abnormal	Show
ZFA:0000114	heart	heart edematous , abnormal	Show
ZFA:0000217	inner ear	inner ear decreased size , abnormal	Show
ZFA:0001117	post-vent region	post-vent region curved ventral , abnormal	Show
ZFA:0009091	melanocyte	melanocyte decreased amount , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000014571	ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*	/ complex / reaction
ENSDARG00000031894	lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*	/ complex / reaction
ENSDARG00000055357	leo1 / Q6NYV9 / LEO1 homolog, Paf1/RNA polymerase II complex component / Q5XJE5* / Q8WVC0* / RNA polymerase-associated protein LEO1 *	/ complex / reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr