ENSGALG00000002469


Gallus gallus
regulationCDC73cellrnapolymeraseiitranscriptioncomplexcdcelongationcycleproliferationhistoneproteinpafpromotermrna-endprocessinggstransitionbindingfactorparafibromindivisioncontrolc-terminalsubunitn-terminaldomain

Features
Gene ID: ENSGALG00000002469
  
Biological name :CDC73
  
Synonyms : CDC73 / Parafibromin / Q5ZLM0
  
Possible biological names infered from orthology : cell division cycle 73 / Q6P1J9 / Q8JZM7
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 3404602
Gene end: 3498996
  
Corresponding Affymetrix probe sets: Gga.8974.1.S1_s_at (Chicken Array)   GgaAffx.1652.1.S1_s_at (Chicken Array)   GgaAffx.1653.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003888
NCBI entrez gene - 424356     See in Manteia.
RefSeq - NM_001031265
RefSeq Peptide - NP_001026436
swissprot - Q5ZLM0
Ensembl - ENSGALG00000002469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc73ENSDARG00000020201Danio rerio
 CDC73ENSG00000134371Homo sapiens
 Cdc73ENSMUSG00000026361Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007852  Cdc73/Parafibromin
 IPR031336  Cell division control protein 73, C-terminal
 IPR032041  Paf1 complex subunit Cdc73, N-terminal domain


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell growthanatomical structure developmentcellular developmental processcell cyclemaintenance of cell numbercell communicationcellular response to stimulusregulation of biological qualitycellular component biogenesiscell deathfibroblast proliferationepithelial cell proliferationresponse to external stimulusresponse to chemicalresponse to biotic stimulusnitrognitrogen compound metabolic processbiosynbiosynthetic processcellulcellular metabolic processprimarprimary metabolic processorganiorganic substance metabolic processcellulcellular component organizationcell gcell growthanatomanatomical structure developmentcellulcellular developmental processcell ccell cyclemaintemaintenance of cell numbercell ccell communicationcellulcellular response to stimulusregularegulation of biological qualitycellulcellular component biogenesiscell dcell deathfibrobfibroblast proliferationepitheepithelial cell proliferationresponresponse to external stimulusresponresponse to chemicalresponresponse to biotic stimulus
protein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein-containing complex bindingtranscription factor activity, protein bindingprotein bindingprotein bindingprotein-containing complex bindingprotein-containing complex bindingtranscription factor activity, protein bindingtranscription factor activity, protein binding
cellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellorganelleprotein-containing complexmembrane-enclosed lumencellcellorganelleorganelleprotein-containing complexprotein-containing complexmembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001711 endodermal cell fate commitment IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0006378 mRNA polyadenylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010390 histone monoubiquitination IEA
 biological_processGO:0016570 histone modification IBA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0031442 positive regulation of mRNA 3"-end processing IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0033523 histone H2B ubiquitination IEA
 biological_processGO:0034402 recruitment of 3"-end processing factors to RNA polymerase II holoenzyme complex IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:1902808 positive regulation of cell cycle G1/S phase transition IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016593 Cdc73/Paf1 complex ISS
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IBA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Hedgehog on state
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008883 TCF7L2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*  / complex / reaction
 ENSGALG00000011630 GLI2 / GLI family zinc finger 2 / P10070* / Q0VGT2* / Zinc finger protein GLI2 *  / complex / reaction
 ENSGALG00000031960 LEF1 / lymphoid enhancer binding factor 1 / P27782* / Q9UJU2*  / complex / reaction
 ENSGALG00000040266 GLI3 / GLI family zinc finger 3 / P10071* / Q61602* / Transcriptional activator GLI3 Transcriptional repressor GLI3R*  / complex / reaction






 

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