ENSDARG00000079198


Danio rerio

Features
Gene ID: ENSDARG00000079198
  
Biological name :usp13
  
Synonyms : F1QFS9 / ubiquitin specific peptidase 13 / usp13
  
Possible biological names infered from orthology : Q5BKP2 / Q92995 / ubiquitin specific peptidase 13 (isopeptidase T-3)
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 29410986
Gene end: 29469208
  
Corresponding Affymetrix probe sets: Dr.1795.1.A1_at (Zebrafish Array)   Dr.628.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000065292
NCBI entrez gene - 558011     See in Manteia.
RefSeq - XM_005165930
RefSeq - XM_021476878
swissprot - F1QFS9
ZFIN ID - ZDB-GENE-080724-7
Ensembl - ENSDARG00000079198
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP13ENSGALG00000008909Gallus gallus
 USP13ENSG00000058056Homo sapiens
 Usp13ENSMUSG00000056900Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
usp5 / ubiquitin specific peptidase 5 (isopeptidase T) / P45974* / P56399* / ubiquitin specific peptidase 5*ENSDARG0000001451752


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR009060  UBA-like superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015940  Ubiquitin-associated domain
 IPR016652  Ubiquitinyl hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0010506 regulation of autophagy ISS
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0070536 protein K63-linked deubiquitination ISS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity ISS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISS
 molecular_functionGO:0043130 ubiquitin binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001115 trunk trunk decreased thickness , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010051 ufd1l / ubiquitin recognition factor in ER associated degradation 1 / UFD1* / P70362* / Q92890*  / complex / reaction
 ENSDARG00000044381 siah2l / seven in absentia homolog 2 (Drosophila)-like / SIAH2* / SIAH3* / Q06986* / O43255* / Q8IW03* / siah E3 ubiquitin protein ligase 2* / siah E3 ubiquitin protein ligase family member 3*  / complex / reaction
 ENSDARG00000079128 becn1 / F1RCP1 / beclin 1, autophagy related / BECN2* / Q14457* / O88597* / P0DM65* / A8MW95* / Gm38100* / beclin 2* / beclin 1* / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa*  / complex
 ENSDARG00000004937 skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase / Q9Z0Z3* / Q13309* / S-phase kinase associated protein 2* / S-phase kinase-associated protein 2 (p45)*  / complex / reaction
 ENSDARG00000103422 usp10 / ubiquitin specific peptidase 10 / P52479* / Q14694*  / complex






 

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