ENSDARG00000079128


Danio rerio

Features
Gene ID: ENSDARG00000079128
  
Biological name :becn1
  
Synonyms : beclin 1, autophagy related / becn1 / F1RCP1
  
Possible biological names infered from orthology : A8MW95 / beclin 1 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / beclin 2 / BECN2 / Gm38100 / O88597 / P0DM65 / Q14457
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 14556092
Gene end: 14703429
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000115678
Ensembl peptide - ENSDARP00000100986
NCBI entrez gene - 393846     See in Manteia.
RefSeq - NM_200872
RefSeq Peptide - NP_957166
swissprot - F1RCP1
swissprot - F1Q7V0
ZFIN ID - ZDB-GENE-040426-1666
Ensembl - ENSDARG00000079128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BECN1ENSGALG00000002973Gallus gallus
 BECN1ENSG00000126581Homo sapiens
 BECN2ENSG00000196289Homo sapiens
 Becn1ENSMUSG00000035086Mus musculus
 P0DM65ENSMUSG00000104158Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007243  Atg6/Beclin
 IPR029318  Beclin-1, BH3 domain
 IPR032913  Beclin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IBA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006914 autophagy IMP
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0043416 regulation of skeletal muscle tissue regeneration IMP
 biological_processGO:0044804 autophagy of nucleus IBA
 biological_processGO:0045022 early endosome to late endosome transport ISS
 biological_processGO:0045324 late endosome to vacuole transport IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090398 cellular senescence IGI
 cellular_componentGO:0000407 phagophore assembly site IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0034271 phosphatidylinositol 3-kinase complex, class III, type I IBA
 cellular_componentGO:0034272 phosphatidylinositol 3-kinase complex, class III, type II IBA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Macroautophagy
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation atrium , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle orientation atrium , abnormal
cardiac ventricle mislocalised , abnormal
cardiac ventricle increased distribution , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart autophagosome decreased amount , abnormal
heart increased amount , abnormal
heart mislocalised , abnormal
heart increased distribution , abnormal
heart structure , abnormal
heart physical object quality , abnormal
Show

 ZFA:0000360 heart tube heart tube linear , abnormal
Show

 ZFA:0000383 lateral rectus lateral rectus skeletal muscle tissue regeneration decreased process quality , abnormal
lateral rectus regenerating tissue decreased length , abnormal
lateral rectus regenerating tissue decreased amount , abnormal
Show

 ZFA:0000471 atrium atrium increased size , abnormal
atrium mislocalised , abnormal
atrium increased distribution , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism bent , abnormal
whole organism decreased amount , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region cell death increased occurrence , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal mislocalised , abnormal
atrioventricular canal increased distribution , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve increased distribution , abnormal
Show

 ZFA:0009000 cell cell autophagosome assembly decreased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017537 prkag3a / protein kinase, AMP-activated, gamma 3a non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / reaction
 ENSDARG00000003818 prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / O54950* / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction
 ENSDARG00000002670 ATG14 / zgc:113944 / Q6ZNE5* / Q8CDJ3* / autophagy related 14* / Beclin 1-associated autophagy-related key regulator *  / complex
 ENSDARG00000046143 prkab1b / protein kinase, AMP-activated, beta 1 non-catalytic subunit, b / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / reaction
 ENSDARG00000036040 atg13 / Q7SYE0 / ATG13 autophagy related 13 homolog (S. cerevisiae) / Q91YI1* / O75143* / autophagy related 13* / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA.*  / reaction
 ENSDARG00000023815 uvrag / UV radiation resistance associated gene / Q8K245* / Q9P2Y5* / UV radiation resistance associated*  / complex
 ENSDARG00000060596 prkaa1 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / Q5EG47* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSDARG00000043287 atg101 / Q3B736 / autophagy related 101 / Q9BSB4* / Q9D8Z6* / Autophagy-related protein 101 *  / reaction
 ENSDARG00000079198 usp13 / F1QFS9 / ubiquitin specific peptidase 13 / Q92995* / Q5BKP2* / ubiquitin specific peptidase 13 (isopeptidase T-3)*  / complex
 ENSDARG00000060641 prkaa2 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSDARG00000060469 pik3r4 / phosphoinositide-3-kinase, regulatory subunit 4 / Q8VD65* / Q99570*  / complex
 ENSDARG00000044183 prkab1a / protein kinase, AMP-activated, beta 1 non-catalytic subunit, a / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / reaction
 ENSDARG00000058454 dynll1 / dynein, light chain, LC8-type 1 / P63168* / P63167* / BC048507* / cDNA sequence BC048507* / Dynein light chain 1, cytoplasmic *  / complex / reaction
 ENSDARG00000076559 rb1cc1 / RB1-inducible coiled-coil 1 / Q8TDY2*  / reaction
 ENSDARG00000067817 CABZ01083448.1 / O43741* / PRKAB2* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSDARG00000054829 pik3c3 / phosphatidylinositol 3-kinase, catalytic subunit type 3 / Q6PF93* / Q8NEB9*  / complex
 ENSDARG00000069790 dynll2a / dynein, light chain, LC8-type 2a / Q9D0M5* / DYNLL2* / Q96FJ2* / dynein light chain LC8-type 2* / Dynein light chain 2, cytoplasmic *  / complex / reaction
 ENSDARG00000000369 prkag3b / protein kinase, AMP-activated, gamma 3b non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / reaction
 ENSDARG00000074481 ulk1b / unc-51 like autophagy activating kinase 1 / ULK1* / O75385* / unc-51 like kinase 1*  / reaction






 

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