ENSG00000126581


Homo sapiens

Features
Gene ID: ENSG00000126581
  
Biological name :BECN1
  
Synonyms : beclin 1 / BECN1 / Q14457
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.31
Gene start: 42810134
Gene end: 42833350
  
Corresponding Affymetrix probe sets: 1561652_at (Human Genome U133 Plus 2.0 Array)   208945_s_at (Human Genome U133 Plus 2.0 Array)   208946_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468104
Ensembl peptide - ENSP00000467937
Ensembl peptide - ENSP00000468461
Ensembl peptide - ENSP00000479791
Ensembl peptide - ENSP00000468597
Ensembl peptide - ENSP00000355231
Ensembl peptide - ENSP00000416173
Ensembl peptide - ENSP00000465364
Ensembl peptide - ENSP00000465658
Ensembl peptide - ENSP00000465964
Ensembl peptide - ENSP00000466281
Ensembl peptide - ENSP00000466419
Ensembl peptide - ENSP00000466766
NCBI entrez gene - 8678     See in Manteia.
OMIM - 604378
RefSeq - XM_017025264
RefSeq - NM_001313998
RefSeq - NM_001313999
RefSeq - NM_001314000
RefSeq - NM_003766
RefSeq - XM_005257759
RefSeq - XM_005257760
RefSeq - XM_011525421
RefSeq - XM_017025262
RefSeq - XM_017025263
RefSeq Peptide - NP_003757
RefSeq Peptide - NP_001300927
RefSeq Peptide - NP_001300928
RefSeq Peptide - NP_001300929
swissprot - E7EV84
swissprot - A0A087WVZ2
swissprot - K7EKK2
swissprot - K7EL88
swissprot - K7ELY9
swissprot - K7EMA2
swissprot - K7EN35
swissprot - K7EQQ7
swissprot - K7ERY0
swissprot - K7ER46
swissprot - K7ES83
swissprot - Q14457
swissprot - A0A024R1X5
Ensembl - ENSG00000126581
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 becn1ENSDARG00000079128Danio rerio
 BECN1ENSGALG00000002973Gallus gallus
 Becn1ENSMUSG00000035086Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BECN2 / A8MW95 / beclin 2ENSG0000019628953


Protein motifs (from Interpro)
Interpro ID Name
 IPR007243  Atg6/Beclin
 IPR029318  Beclin-1, BH3 domain
 IPR032913  Beclin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IBA
 biological_processGO:0000422 autophagy of mitochondrion IMP
 biological_processGO:0000423 mitophagy IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010040 response to iron(II) ion IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling NAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016236 macroautophagy ISS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0032801 receptor catabolic process IMP
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0042149 cellular response to glucose starvation ISS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043652 engulfment of apoptotic cell IEA
 biological_processGO:0044804 autophagy of nucleus IBA
 biological_processGO:0045022 early endosome to late endosome transport IMP
 biological_processGO:0045324 late endosome to vacuole transport IBA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0050435 amyloid-beta metabolic process IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051707 response to other organism IEA
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071275 cellular response to aluminum ion IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0098780 response to mitochondrial depolarisation IMP
 biological_processGO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore IMP
 biological_processGO:1902902 negative regulation of autophagosome assembly IEA
 biological_processGO:1905672 negative regulation of lysosome organization IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000786 positive regulation of autophagosome assembly IEA
 cellular_componentGO:0000407 phagophore assembly site IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0034271 phosphatidylinositol 3-kinase complex, class III, type I IBA
 cellular_componentGO:0034272 phosphatidylinositol 3-kinase complex, class III, type II IBA
 cellular_componentGO:0035032 phosphatidylinositol 3-kinase complex, class III ISS
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IPI
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Macroautophagy
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000126775 ATG14 / Q6ZNE5 / autophagy related 14  / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / complex
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / reaction
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex / reaction
 ENSG00000058056 USP13 / Q92995 / ubiquitin specific peptidase 13  / complex
 ENSG00000110497 AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1  / complex / reaction
 ENSG00000198382 UVRAG / Q9P2Y5 / UV radiation resistance associated  / complex
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / complex
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction






 

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