ENSG00000198382


Homo sapiens
proteinUVRAGregulationdomainchromosomecomplexendosomebindingcdnarepairvesicle-mediatedtransportgolgicentrosomesnarekinaseuvradiationresistanceautophagy-relatedsuperfamilyretrogradeerautophagycellularresponsedamagestimulusspindleorganization

Features
Gene ID: ENSG00000198382
  
Biological name :UVRAG
  
Synonyms : Q9P2Y5 / UV radiation resistance associated / UVRAG
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.5
Gene start: 75815167
Gene end: 76143195
  
Corresponding Affymetrix probe sets: 203241_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434082
Ensembl peptide - ENSP00000433613
Ensembl peptide - ENSP00000436039
Ensembl peptide - ENSP00000436270
Ensembl peptide - ENSP00000348455
Ensembl peptide - ENSP00000431256
Ensembl peptide - ENSP00000433414
NCBI entrez gene - 7405     See in Manteia.
OMIM - 602493
RefSeq - XM_017018227
RefSeq - XM_011545227
RefSeq - XM_011545228
RefSeq - XM_017018224
RefSeq - XM_017018225
RefSeq - XM_017018226
RefSeq - NM_003369
RefSeq - XM_011545226
RefSeq Peptide - NP_003360
swissprot - E9PR71
swissprot - H0YDD1
swissprot - E9PK00
swissprot - Q9P2Y5
Ensembl - ENSG00000198382
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uvragENSDARG00000023815Danio rerio
 UVRAGENSGALG00000000845Gallus gallus
 UvragENSMUSG00000035354Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR018791  UV radiation resistance protein/autophagy-related protein 14
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusestablishment of localizationcatabolic processprocess utilizing autophagic mechanismcellular component organizationcell cyclemicrotubule-based processchromosome segregationcell divisioncellular component biogenesisinterspecies interaction between organismsregulation of biological qualitycellular localizationregulation of molecular functionnitrogenitrogen compound metabolic processresponsresponse to stresscellulacellular metabolic processprimaryprimary metabolic processorganicorganic substance metabolic processcellulacellular response to stimulusestabliestablishment of localizationcatabolcatabolic processprocessprocess utilizing autophagic mechanismcellulacellular component organizationcell cycell cyclemicrotumicrotubule-based processchromoschromosome segregationcell dicell divisioncellulacellular component biogenesisinterspinterspecies interaction between organismsregulatregulation of biological qualitycellulacellular localizationregulatregulation of molecular function
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP
 biological_processGO:0006914 autophagy IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0032465 regulation of cytokinesis IMP
 biological_processGO:0032801 receptor catabolic process IMP
 biological_processGO:0035493 SNARE complex assembly IBA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0051684 maintenance of Golgi location IMP
 biological_processGO:0060627 regulation of vesicle-mediated transport IBA
 biological_processGO:0071900 regulation of protein serine/threonine kinase activity IDA
 biological_processGO:0071985 multivesicular body sorting pathway TAS
 biological_processGO:0097680 double-strand break repair via classical nonhomologous end joining IDA
 biological_processGO:1901098 positive regulation of autophagosome maturation TAS
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0030897 HOPS complex TAS
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0070418 DNA-dependent protein kinase complex IDA
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / complex
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / complex
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / complex






 

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