ENSG00000131791


Homo sapiens

Features
Gene ID: ENSG00000131791
  
Biological name :PRKAB2
  
Synonyms : O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.1
Gene start: 147155106
Gene end: 147172550
  
Corresponding Affymetrix probe sets: 1558027_s_at (Human Genome U133 Plus 2.0 Array)   214474_at (Human Genome U133 Plus 2.0 Array)   225278_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000254101
NCBI entrez gene - 5565     See in Manteia.
OMIM - 602741
RefSeq - XM_017001697
RefSeq - NM_005399
RefSeq - XM_011509729
RefSeq Peptide - NP_005390
swissprot - O43741
Ensembl - ENSG00000131791
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01083448.1ENSDARG00000067817Danio rerio
 PRKAB2ENSGALG00000001678Gallus gallus
 Prkab2ENSMUSG00000038205Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1ENSG0000011172570


Protein motifs (from Interpro)
Interpro ID Name
 IPR006828  Association with the SNF1 complex (ASC) domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR032640  AMP-activated protein kinase, glycogen-binding domain
 IPR037256  ASC domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006853 carnitine shuttle TAS
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0042304 regulation of fatty acid biosynthetic process TAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IDA
 molecular_functionGO:0004679 AMP-activated protein kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
Import of palmitoyl-CoA into the mitochondrial matrix
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / complex / reaction
 ENSG00000103197 TSC2 / P49815 / TSC complex subunit 2  / reaction
 ENSG00000126775 ATG14 / Q6ZNE5 / autophagy related 14  / reaction
 ENSG00000130766 SESN2 / P58004 / sestrin 2  / complex / reaction
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / complex
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / reaction
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / reaction
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / reaction
 ENSG00000009950 MLXIPL / Q9NP71 / MLX interacting protein like  / reaction
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / reaction
 ENSG00000080546 SESN1 / Q9Y6P5 / sestrin 1  / complex / reaction
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / complex
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / reaction
 ENSG00000165699 TSC1 / Q92574 / TSC complex subunit 1  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / complex
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / complex / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / complex / reaction
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / reaction
 ENSG00000110497 AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1  / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / complex / reaction
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / reaction
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / reaction
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / complex
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / reaction
 ENSG00000100614 PPM1A / P35813 / protein phosphatase, Mg2+/Mn2+ dependent 1A  / reaction
 ENSG00000118046 STK11 / Q15831 / serine/threonine kinase 11  / reaction






 

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