Manteia

ENSG00000100614

Homo sapiens

Features

Gene ID:	ENSG00000100614

Biological name :	PPM1A

Synonyms :	P35813 / PPM1A / protein phosphatase, Mg2+/Mn2+ dependent 1A

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	14
Strand:	1
Band:	q23.1
Gene start:	60245752
Gene end:	60299087

Corresponding Affymetrix probe sets:	203966_s_at (Human Genome U133 Plus 2.0 Array) 210407_at (Human Genome U133 Plus 2.0 Array) 227728_at (Human Genome U133 Plus 2.0 Array) 229027_at (Human Genome U133 Plus 2.0 Array) 231370_at (Human Genome U133 Plus 2.0 Array) 235344_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000327255 Ensembl peptide - ENSP00000314850 Ensembl peptide - ENSP00000378514 Ensembl peptide - ENSP00000437200 Ensembl peptide - ENSP00000436445 Ensembl peptide - ENSP00000435575 Ensembl peptide - ENSP00000435398 Ensembl peptide - ENSP00000431453 NCBI entrez gene - 5494 See in Manteia. OMIM - 606108 RefSeq - XM_017021387 RefSeq - XM_011536881 RefSeq - XM_011536882 RefSeq - XM_011536883 RefSeq - XM_011536884 RefSeq - XM_017021381 RefSeq - XM_017021382 RefSeq - XM_017021383 RefSeq - XM_017021384 RefSeq - XM_017021385 RefSeq - XM_017021386 RefSeq - NM_021003 RefSeq - NM_177951 RefSeq - NM_177952 RefSeq - XM_005267779 RefSeq - XM_005267781 RefSeq - XM_011536872 RefSeq - XM_011536876 RefSeq - XM_011536877 RefSeq - XM_011536878 RefSeq - XM_011536879 RefSeq - XM_011536880 RefSeq Peptide - NP_808820 RefSeq Peptide - NP_808821 RefSeq Peptide - NP_066283 swissprot - E9PKB5 swissprot - E9PJN3 swissprot - E9PP44 swissprot - P35813 swissprot - A0A024R6A5 swissprot - E9PNE1 swissprot - E9PL75 Ensembl - ENSG00000100614

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ppm1aa	ENSDARG00000032155	Danio rerio
ppm1ab	ENSDARG00000043250	Danio rerio
PPM1A	ENSGALG00000011917	Gallus gallus
Ppm1a	ENSMUSG00000021096	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
PPM1B / O75688 / protein phosphatase, Mg2+/Mn2+ dependent 1B	ENSG00000138032	64
PPM1N / Q8N819 / protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)	ENSG00000213889	36

Protein motifs (from Interpro)

Interpro ID	Name
IPR000222	PPM-type phosphatase, divalent cation binding
IPR001932	PPM-type phosphatase domain
IPR012911	Protein serine/threonine phosphatase 2C, C-terminal
IPR015655	Protein phosphatase 2C family
IPR036457	PPM-type phosphatase domain superfamily
IPR036580	Phosphatase 2C, C-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	TAS
biological_process	GO:0006470	protein dephosphorylation	IEA
biological_process	GO:0006499	N-terminal protein myristoylation	ISS
biological_process	GO:0007050	cell cycle arrest	TAS
biological_process	GO:0010991	negative regulation of SMAD protein complex assembly	IDA
biological_process	GO:0016055	Wnt signaling pathway	IDA
biological_process	GO:0016311	dephosphorylation	IDA
biological_process	GO:0030177	positive regulation of Wnt signaling pathway	IDA
biological_process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IDA
biological_process	GO:0030514	negative regulation of BMP signaling pathway	IEA
biological_process	GO:0035970	peptidyl-threonine dephosphorylation	IDA
biological_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	HMP
biological_process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0046827	positive regulation of protein export from nucleus	IEA
biological_process	GO:0071560	cellular response to transforming growth factor beta stimulus	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0016020	membrane	ISS
molecular_function	GO:0000287	magnesium ion binding	IEA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004721	phosphoprotein phosphatase activity	IEA
molecular_function	GO:0004722	protein serine/threonine phosphatase activity	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	HMP
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0030145	manganese ion binding	IEA
molecular_function	GO:0033192	calmodulin-dependent protein phosphatase activity	IDA
molecular_function	GO:0043169	cation binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0070412	R-SMAD binding	IPI

Pathways (from Reactome)

Pathway description

Downregulation of SMAD2/3:SMAD4 transcriptional activity

Energy dependent regulation of mTOR by LKB1-AMPK

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000175387	SMAD2 / Q15796 / SMAD family member 2	/ complex / reaction
ENSG00000166949	SMAD3 / P84022 / SMAD family member 3	/ complex / reaction
ENSG00000141646	SMAD4 / Q13485 / SMAD family member 4	/ complex / reaction
ENSG00000111725	PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1	/ reaction
ENSG00000131791	O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2	/ reaction
ENSG00000115592	PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3	/ reaction
ENSG00000106617	PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2	/ reaction
ENSG00000132356	PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1	/ reaction
ENSG00000181929	P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1	/ reaction
ENSG00000162409	P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr