ENSGALG00000011917


Gallus gallus

Features
Gene ID: ENSGALG00000011917
  
Biological name :PPM1A
  
Synonyms : PPM1A / protein phosphatase, Mg2+/Mn2+ dependent 1A
  
Possible biological names infered from orthology : P35813 / P49443 / protein phosphatase 1A, magnesium dependent, alpha isoform
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 54600924
Gene end: 54613644
  
Corresponding Affymetrix probe sets: GgaAffx.7572.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019417
Ensembl peptide - ENSGALP00000060448
NCBI entrez gene - 423525     See in Manteia.
RefSeq - XM_015287915
RefSeq - XM_015287914
swissprot - E1BVM8
swissprot - A0A1L1RNU6
Ensembl - ENSGALG00000011917
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppm1aaENSDARG00000032155Danio rerio
 ppm1abENSDARG00000043250Danio rerio
 PPM1AENSG00000100614Homo sapiens
 Ppm1aENSMUSG00000021096Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPM1B / protein phosphatase 1B / P36993* / O75688* / protein phosphatase, Mg2+/Mn2+ dependent 1B* / protein phosphatase 1B, magnesium dependent, beta isoform*ENSGALG0000003069178


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR012911  Protein serine/threonine phosphatase 2C, C-terminal
 IPR015655  Protein phosphatase 2C family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006499 N-terminal protein myristoylation IEA
 biological_processGO:0010991 negative regulation of SMAD protein complex assembly IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Energy dependent regulation of mTOR by LKB1-AMPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001678 PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2 / O43741* / Q6PAM0* / protein kinase, AMP-activated, beta 2 non-catalytic subunit*  / reaction
 ENSGALG00000007373 PRKAB1 / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-activated, beta 1 non-catalytic subunit*  / reaction
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000014832 PRKAA1 / protein kinase AMP-activated catalytic subunit alpha 1 / Q13131* / Q5EG47* / protein kinase, AMP-activated, alpha 1 catalytic subunit*  / reaction
 ENSGALG00000010826 PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2 / P54646* / Q8BRK8* / protein kinase, AMP-activated, alpha 2 catalytic subunit*  / reaction
 ENSGALG00000011360 PRKAG3 / 5-AMP-activated protein kinase subunit gamma-3 / Q9UGI9* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-activated, gamma 3 non-catat...  / reaction
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000036282 O54950* / P54619* / PRKAG1* / protein kinase AMP-activated non-catalytic subunit gamma 1* / protein kinase, AMP-activated, gamma 1 non-catalytic subunit*  / reaction






 

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