ENSGALG00000036001


Gallus gallus

Features
Gene ID: ENSGALG00000036001
  
Biological name :SMAD2Z
  
Synonyms : SMAD2Z
  
Possible biological names infered from orthology : Mothers against decapentaplegic homolog 2 / Q15796 / Q62432 / SMAD2 / SMAD family member 2
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 1515765
Gene end: 1555787
  
Corresponding Affymetrix probe sets: Gga.161.1.S1_at (Chicken Array)   Gga.16345.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000058482
Ensembl peptide - ENSGALP00000055416
NCBI entrez gene - 395247     See in Manteia.
RefSeq - NM_204561
RefSeq Peptide - NP_989892
swissprot - Q8UWF3
swissprot - A0A1D5PR93
Ensembl - ENSGALG00000036001
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smad2ENSDARG00000006389Danio rerio
 SMAD2ENSG00000175387Homo sapiens
 Smad2ENSMUSG00000024563Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *ENSGALG0000001418499
SMAD3 / mothers against decapentaplegic homolog 3 / P84022* / Q8BUN5* / SMAD family member 3*ENSGALG0000003570185
SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*ENSGALG0000000630961
SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*ENSGALG0000000997760
SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*ENSGALG0000001705060
SMAD4* / P97471* / Q13485* / SMAD family member 4* / Mothers against decapentaplegic homolog 4 *ENSGALG0000003941737
SMAD6 / mothers against decapentaplegic homolog 6 / O35182* / O43541* / SMAD family member 6*ENSGALG0000002589824
SMAD7B / Gallus gallus TGF-beta signal pathway antagonist Smad7 (SMAD7B), mRNA. / SMAD7* / O35253* / O15105* / SMAD family member 7*ENSGALG0000002954523
SMAD7* / O15105* / O35253* / SMAD family member 7*ENSGALG0000003716022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0042327 positive regulation of phosphorylation IPI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046332 SMAD binding IPI


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001042 MTMR4 / myotubularin related protein 4 / Q91XS1* / Q9NYA4* / Mus musculus myotubularin related protein 4 (Mtmr4), transcript variant 2, mRNA.*  / complex / reaction
 ENSGALG00000001722 E2F4 / E2F transcription factor 4 / Q16254* / Q8R0K9* / Transcription factor E2F4 *  / complex / reaction
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex / reaction
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSGALG00000024081 TGIF2 / TGFB induced factor homeobox 2 / Q8C0Y1* / Q9GZN2*  / complex / reaction
 ENSGALG00000010412 WWTR1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / complex / reaction
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000014795 TGIF1 / Q90655 / Homeobox protein AKR / Q15583* / P70284* / TGFB induced factor homeobox 1*  / complex / reaction
 ENSGALG00000011917 PPM1A / protein phosphatase, Mg2+/Mn2+ dependent 1A / P35813* / P49443* / protein phosphatase 1A, magnesium dependent, alpha isoform*  / complex / reaction
 ENSGALG00000016823 TFDP1* / TFDP3* / Q5H9I0* / Q08639* / Q14186* / transcription factor Dp-1* / transcription factor Dp family member 3*  / complex / reaction
 ENSGALG00000015297 FOXO3 / forkhead box O3 / O43524* / Q9WVH4* / Forkhead box protein O3 *  / complex / reaction
 ENSGALG00000012207 CCNT2 / cyclin T2 / O60583* / Q7TQK0*  / reaction
 ENSGALG00000017104 CDK8 / cyclin dependent kinase 8 / P49336* / Q8R3L8*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000001229 SKI / ski oncogene / P12755* / SKI proto-oncogene*  / complex / reaction
 ENSGALG00000001976 TRIM33 / tripartite motif containing 33 / Q9UPN9*  / complex / reaction
 ENSGALG00000010613 ZFYVE9 / zinc finger FYVE-type containing 9 / O95405* / zinc finger, FYVE domain containing 9*  / reaction
 ENSGALG00000011442 Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*  / reaction
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSGALG00000033179 TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000041257 ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *  / reaction
 ENSGALG00000025759 TFDP2 / transcription factor Dp-2 / Q14188*  / complex / reaction
 ENSGALG00000029599 ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *  / reaction
 ENSGALG00000015471 CCNC / P55168 / Cyclin-C / P24863* / Q62447*  / reaction
 ENSGALG00000035487 SP1 / Sp1 transcription factor / O89090* / P08047* / Transcription factor Sp1 *  / complex / reaction
 ENSGALG00000038915 E2F5 / transcription factor E2F5 / Q15329* / Q61502* / E2F transcription factor 5*  / complex / reaction
 ENSGALG00000035576 CDK9 / Q5ZKN1 / Cyclin-dependent kinase 9 / P50750* / Q99J95*  / reaction






 

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