ENSGALG00000003566


Gallus gallus

Features
Gene ID: ENSGALG00000003566
  
Biological name :SMURF2
  
Synonyms : SMAD specific E3 ubiquitin protein ligase 2 / SMURF2
  
Possible biological names infered from orthology : A2A5Z6 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4
  
Species: Gallus gallus
  
Chr. number: 18
Strand: -1
Band:
Gene start: 6986939
Gene end: 7040227
  
Corresponding Affymetrix probe sets: Gga.14876.1.S1_s_at (Chicken Array)   GgaAffx.2221.1.S1_at (Chicken Array)   GgaAffx.2221.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052166
Ensembl peptide - ENSGALP00000005637
NCBI entrez gene - 427809     See in Manteia.
RefSeq - XM_425380
RefSeq - XM_015279908
swissprot - F1NJU6
swissprot - A0A1D5PH89
Ensembl - ENSGALG00000003566
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A9JRZ0ENSDARG00000038067Danio rerio
 Q9HAU4ENSG00000108854Homo sapiens
 A2A5Z6ENSMUSG00000018363Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *ENSGALG0000000465575
NEDD4L* / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSGALG0000003135540
NEDD4L* / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSGALG0000003458440
ITCH / itchy E3 ubiquitin protein ligase / Q8C863* / Q96J02* / E3 ubiquitin-protein ligase Itchy *ENSGALG0000004047440
WWP2 / NEDD4-like E3 ubiquitin-protein ligase WWP2 / O00308* / Q9DBH0* / WW domain containing E3 ubiquitin protein ligase 2*ENSGALG0000000069939
WWP1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*ENSGALG0000004179539
NEDD4 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4*ENSGALG0000000434737
HECW2 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 *ENSGALG0000000794435
HECW1 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 / Q76N89* / Q8K4P8* / E3 ubiquitin-protein ligase HECW1 *ENSGALG0000003719335
HACE1 / E1C656 / E3 ubiquitin-protein ligase HACE1 / Q3U0D9* / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSGALG0000001541527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process IEA
 biological_processGO:1901165 positive regulation of trophoblast cell migration IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Degradation of AXIN
Hedgehog on state
Ub-specific processing proteases
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002003 BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000033179 TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*  / complex
 ENSGALG00000029402 AXIN1 / O15169*  / complex / reaction
 ENSGALG00000006158 ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*  / complex / reaction
 ENSGALG00000008459 BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *  / complex / reaction
 ENSGALG00000012444 ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000012216 BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...  / complex / reaction
 ENSGALG00000029301 BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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