ENSGALG00000004347


Gallus gallus

Features
Gene ID: ENSGALG00000004347
  
Biological name :NEDD4
  
Synonyms : NEDD4 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
  
Possible biological names infered from orthology : neural precursor cell expressed, developmentally down-regulated 4 / P46934 / P46935
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 7728653
Gene end: 7801085
  
Corresponding Affymetrix probe sets: Gga.1292.1.S1_s_at (Chicken Array)   Gga.14818.1.S1_s_at (Chicken Array)   GgaAffx.26182.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046890
Ensembl peptide - ENSGALP00000052588
Ensembl peptide - ENSGALP00000052381
Ensembl peptide - ENSGALP00000048991
Ensembl peptide - ENSGALP00000006925
Ensembl peptide - ENSGALP00000044502
Ensembl peptide - ENSGALP00000046551
NCBI entrez gene - 415406     See in Manteia.
RefSeq - XM_015291881
RefSeq - XM_015291878
RefSeq - XM_015291879
RefSeq - XM_015291880
RefSeq - XM_015291877
swissprot - A0A1D5P8E4
swissprot - A0A1D5P1L3
swissprot - E1BWY8
Ensembl - ENSGALG00000004347
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nedd4aENSDARG00000099843Danio rerio
 NEDD4ENSG00000069869Homo sapiens
 Nedd4ENSMUSG00000032216Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEDD4L* / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSGALG0000003458463
NEDD4L* / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSGALG0000003135561
WWP1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*ENSGALG0000004179534
ITCH / itchy E3 ubiquitin protein ligase / Q8C863* / Q96J02* / E3 ubiquitin-protein ligase Itchy *ENSGALG0000004047433
WWP2 / NEDD4-like E3 ubiquitin-protein ligase WWP2 / O00308* / Q9DBH0* / WW domain containing E3 ubiquitin protein ligase 2*ENSGALG0000000069932
HECW2 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 *ENSGALG0000000794432
HECW1 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 / Q76N89* / Q8K4P8* / E3 ubiquitin-protein ligase HECW1 *ENSGALG0000003719332
SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *ENSGALG0000000356630
SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *ENSGALG0000000465529
HACE1 / E1C656 / E3 ubiquitin-protein ligase HACE1 / Q3U0D9* / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSGALG0000001541523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003197 endocardial cushion development IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006622 protein targeting to lysosome IEA
 biological_processGO:0007041 lysosomal transport IEA
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0010766 negative regulation of sodium ion transport IEA
 biological_processGO:0010768 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019089 transmission of virus IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0032801 receptor catabolic process IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IEA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
 biological_processGO:0044111 development involved in symbiotic interaction IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0046824 positive regulation of nucleocytoplasmic transport IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 biological_processGO:0050807 regulation of synapse organization IEA
 biological_processGO:0050847 progesterone receptor signaling pathway IEA
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019871 sodium channel inhibitor activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031698 beta-2 adrenergic receptor binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0050815 phosphoserine residue binding IEA
 molecular_functionGO:0050816 phosphothreonine residue binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0070063 RNA polymerase binding IEA
 molecular_functionGO:0070064 proline-rich region binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

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