ENSGALG00000040474


Gallus gallus

Features
Gene ID: ENSGALG00000040474
  
Biological name :ITCH
  
Synonyms : ITCH / itchy E3 ubiquitin protein ligase
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase Itchy / Q8C863 / Q96J02
  
Species: Gallus gallus
  
Chr. number: 20
Strand: -1
Band:
Gene start: 1525963
Gene end: 1560004
  
Corresponding Affymetrix probe sets: Gga.10549.1.S1_s_at (Chicken Array)   Gga.9750.1.S1_s_at (Chicken Array)   GgaAffx.1295.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055208
NCBI entrez gene - 419145     See in Manteia.
RefSeq - XM_417330
swissprot - A0A1D5PQP3
Ensembl - ENSGALG00000040474
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itchaENSDARG00000074903Danio rerio
 itchbENSDARG00000099199Danio rerio
 ITCHENSG00000078747Homo sapiens
 ItchENSMUSG00000027598Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WWP1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*ENSGALG0000004179561
WWP2 / NEDD4-like E3 ubiquitin-protein ligase WWP2 / O00308* / Q9DBH0* / WW domain containing E3 ubiquitin protein ligase 2*ENSGALG0000000069957
NEDD4L* / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSGALG0000003458438
NEDD4L* / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSGALG0000003135537
SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *ENSGALG0000000356634
NEDD4 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4*ENSGALG0000000434734
SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *ENSGALG0000000465534
HECW1 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 / Q76N89* / Q8K4P8* / E3 ubiquitin-protein ligase HECW1 *ENSGALG0000003719334
HECW2 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 *ENSGALG0000000794433
HACE1 / E1C656 / E3 ubiquitin-protein ligase HACE1 / Q3U0D9* / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSGALG0000001541524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0002669 positive regulation of T cell anergy IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0035519 protein K29-linked ubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0046642 negative regulation of alpha-beta T cell proliferation IEA
 biological_processGO:0050687 negative regulation of defense response to virus IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:0090085 regulation of protein deubiquitination IEA
 biological_processGO:2000646 positive regulation of receptor catabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:1990763 arrestin family protein binding IEA


Pathways (from Reactome)
Pathway description
Negative Regulation of MDA5 signaling
Downregulation of ERBB4 signaling
Activated NOTCH1 Transmits Signal to the Nucleus
Degradation of GLI1 by the proteasome
Hedgehog on state
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008096 SUFU / SUFU negative regulator of hedgehog signaling / Q9UMX1* / Q9Z0P7*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

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