ENSGALG00000003126


Gallus gallus

Features
Gene ID: ENSGALG00000003126
  
Biological name :ERBB4
  
Synonyms : ERBB4 / receptor tyrosine-protein kinase erbB-4
  
Possible biological names infered from orthology : erb-b2 receptor tyrosine kinase 4 / Q15303 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 3073321
Gene end: 3558739
  
Corresponding Affymetrix probe sets: Gga.393.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052431
Ensembl peptide - ENSGALP00000064704
Ensembl peptide - ENSGALP00000039169
NCBI entrez gene - 395671     See in Manteia.
RefSeq - XM_015289118
RefSeq - XM_015289114
RefSeq - XM_015289115
RefSeq - XM_015289116
RefSeq - XM_015289117
RefSeq - NM_001030365
RefSeq Peptide - NP_001025536
swissprot - A0A1L1S0Q6
swissprot - F1P258
swissprot - A0A1D5PHZ9
Ensembl - ENSGALG00000003126
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egfraENSDARG00000013847Danio rerio
 LO018309.1ENSDARG00000056909Danio rerio
 ERBB4ENSG00000178568Homo sapiens
 Erbb4ENSMUSG00000062209Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EGFR / epidermal growth factor receptor / P00533* / Q01279*ENSGALG0000003808950
ERBB3 / receptor tyrosine-protein kinase erbB-3 precursor / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSGALG0000003351047
ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *ENSGALG0000003152946
PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSGALG0000003174116
PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*ENSGALG0000001656415
TNK2 / tyrosine kinase non receptor 2 / Q07912*ENSGALG0000002798313
ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...ENSGALG0000000148612
SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*ENSGALG0000001521612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009880 embryonic pattern specification IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021551 central nervous system morphogenesis IEA
 biological_processGO:0021889 olfactory bulb interneuron differentiation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060644 mammary gland epithelial cell differentiation IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:0061026 cardiac muscle tissue regeneration IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IEA
 biological_processGO:2001223 negative regulation of neuron migration IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
Downregulation of ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Downregulation of ERBB2 signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / complex / reaction
 ENSGALG00000004347 NEDD4 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4*  / complex / reaction
 ENSGALG00000009073 PSEN2 / presenilin 2 / P49810*  / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / complex / reaction
 ENSGALG00000009320 PSEN1 / Q4JIM4 / Presenilin-1 Presenilin-1 NTF subunit Presenilin-1 CTF subunit / P49768* / P49769* / presenilin 1*  / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction
 ENSGALG00000000736 MATK / megakaryocyte-associated tyrosine kinase / P42679*  / complex / reaction
 ENSGALG00000003282 STAT5B / signal transducer and activator of transcription 5B / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000012356 TAB2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q99K90* / Q9NYJ8* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex
 ENSGALG00000014773 ERBIN / erbb2 interacting protein / Q80TH2* / Q96RT1*  / reaction
 ENSGALG00000010624 MEMO1 / mediator of cell motility 1 / Q91VH6* / Q9Y316* / Protein MEMO1 *  / complex / reaction
 ENSGALG00000033641 NRG2 / neuregulin 2 / O14511*  / complex / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / complex / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000040474 ITCH / itchy E3 ubiquitin protein ligase / Q8C863* / Q96J02* / E3 ubiquitin-protein ligase Itchy *  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSGALG00000041795 WWP1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000042569 P35831* / PTPN12* / Q05209* / protein tyrosine phosphatase, non-receptor type 12*  / reaction
 ENSGALG00000045163 APH1A / aph-1 homolog A, gamma-secretase subunit / Q8BVF7* / Q96BI3* / Gamma-secretase subunit APH-1A *  / reaction






 

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