ENSGALG00000030943


Gallus gallus

Features
Gene ID: ENSGALG00000030943
  
Biological name :KRAS
  
Synonyms : KRAS / KRAS proto-oncogene, GTPase
  
Possible biological names infered from orthology : GTPase KRas GTPase KRas, N-terminally processed / P01116 / P32883
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 67241669
Gene end: 67263388
  
Corresponding Affymetrix probe sets: Gga.5671.1.S1_at (Chicken Array)   GgaAffx.24341.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045292
Ensembl peptide - ENSGALP00000056138
NCBI entrez gene - 418207     See in Manteia.
RefSeq - XM_015290272
RefSeq - XM_015290247
RefSeq - XM_015290254
RefSeq - XM_015290265
RefSeq - NM_001256162
RefSeq Peptide - NP_001243091
swissprot - A0A1D5PT95
swissprot - A0A1D5NY37
Ensembl - ENSGALG00000030943
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KRASENSG00000133703Homo sapiens
 KrasENSMUSG00000030265Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRAS / GTPase NRas precursor / P01111* / neuroblastoma ras oncogene* / NRAS proto-oncogene, GTPase*ENSGALG0000002669288
H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*ENSGALG0000002926087
H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*ENSGALG0000003452687
RRAS2 / RAS related 2 / P62070* / P62071* / Ras-related protein R-Ras2 *ENSGALG0000000599854
MRAS / muscle RAS oncogene homolog / O08989* / O14807* / muscle and microspikes RAS*ENSGALG0000001159252
RALA / RAS like proto-oncogene A / P11233* / P63321* / Ras-related protein Ral-A *ENSGALG0000003189349
RALB / RAS like proto-oncogene B / P11234* / Q9JIW9* / Ras-related protein Ral-B *ENSGALG0000002649346
RERG / RAS like estrogen regulated growth inhibitor / Q8R367* / Q96A58* / Ras-related and estrogen-regulated growth inhibitor *ENSGALG0000002818637
ENSGALG0000002777834
RASL11A / RAS like family 11 member A / Q6IMB1* / Q6T310* / Ras-like protein family member 11A *ENSGALG0000001709931
GEM / GTP-binding protein GEM / P55040* / P55041* / GTP binding protein overexpressed in skeletal muscle*ENSGALG0000003250631
RASL12 / RAS like family 12 / Q08AT1* / Q9NYN1* / Ras-like protein family member 12 *ENSGALG0000000734930
REM1 / RRAD and GEM like GTPase 1 / O35929* / O75628* / GTP-binding protein REM 1 *ENSGALG0000004560230
RRAD / GTP-binding protein RAD / P55042* / Ras-related associated with diabetes* / RRAD, Ras related glycolysis inhibitor and calcium channel regulator*ENSGALG0000000514029
ENSGALG0000000771028
RERGL / RERG like / Q9H628* / RERG/RAS-like*ENSGALG0000001311228
RASL11B / RAS like family 11 member B / Q922H7* / Q9BPW5* / Ras-like protein family member 11B *ENSGALG0000001394828


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0021897 forebrain astrocyte development IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0035022 positive regulation of Rac protein signal transduction IEA
 biological_processGO:0038002 endocrine signaling IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / reaction
 ENSGALG00000015708 FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*  / reaction
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / reaction
 ENSGALG00000003412 RGL4* / RGL2* / Q12967* / Q61193* / RALGDS* / Q8IZJ4* / O15211* / Q03385* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissociation stimulator li...  / complex / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / reaction
 ENSGALG00000007403 PEBP1 / phosphatidylethanolamine binding protein 1 / Pbp2* / P30086* / P70296*  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction
 ENSGALG00000011505 MARK3 / microtubule affinity regulating kinase 3 / P27448* / Q03141* / MAP/microtubule affinity-regulating kinase 3 *  / complex / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / complex / reaction
 ENSGALG00000028543 FGFR4 / fibroblast growth factor receptor 4 / P22455*  / reaction
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / reaction
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSGALG00000010435 RASGRP3 / RAS guanyl releasing protein 3 / Q8IV61*  / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / reaction
 ENSGALG00000023541 SPHK1 / sphingosine kinase 1 / Q8CI15* / Q9NYA1*  / reaction
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / reaction
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / reaction
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex / reaction
 ENSGALG00000028376 FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / reaction
 ENSGALG00000009495 FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *  / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex / reaction
 ENSGALG00000017706 RASA1* / P20936* / RAS p21 protein activator 1*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction






 

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