ENSGALG00000001501


Gallus gallus

Features
Gene ID: ENSGALG00000001501
  
Biological name :MAPK1
  
Synonyms : MAPK1 / mitogen-activated protein kinase 1
  
Possible biological names infered from orthology : Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482 / P63085
  
Species: Gallus gallus
  
Chr. number: 15
Strand: 1
Band:
Gene start: 505903
Gene end: 529524
  
Corresponding Affymetrix probe sets: Gga.15707.1.S1_at (Chicken Array)   Gga.18672.1.S1_at (Chicken Array)   Gga.2163.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002278
NCBI entrez gene - 373953     See in Manteia.
RefSeq - NM_204150
RefSeq - XM_015275131
RefSeq Peptide - NP_989481
swissprot - Q8UWG6
Ensembl - ENSGALG00000001501
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk1ENSDARG00000027552Danio rerio
 MAPK1ENSG00000100030Homo sapiens
 Mapk1ENSMUSG00000063358Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLK / nemo like kinase / O54949* / Q9UBE8* / Serine/threonine-protein kinase NLK *ENSGALG0000000569941
MAPK6 / Q5F3W3 / Mitogen-activated protein kinase 6 / Q16659* / Q61532*ENSGALG0000003144841
MAPK15 / mitogen-activated protein kinase 15 / Q80Y86* / Q8TD08*ENSGALG0000002927938


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008349  Mitogen-activated protein (MAP) kinase, ERK1/2
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0014032 neural crest cell development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0019858 cytosine metabolic process IEA
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030641 regulation of cellular pH IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0038127 ERBB signaling pathway IEA
 biological_processGO:0042473 outer ear morphogenesis IEA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060020 Bergmann glial cell differentiation IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060440 trachea formation IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0061308 cardiac neural crest cell development involved in heart development IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070849 response to epidermal growth factor IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
 biological_processGO:1903351 cellular response to dopamine IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031143 pseudopodium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
phospho-PLA2 pathway
RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Spry regulation of FGF signaling
Golgi Cisternae Pericentriolar Stack Reorganization
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
ERK2 activation
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Neutrophil degranulation
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000055 Q5ZIP2 / LAMTOR3 / Ragulator complex protein LAMTOR3 / O88653* / Q9UHA4* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3*  / complex / reaction
 ENSGALG00000015708 FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*  / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000001143 ETS1 / protein C-ets-1 / P14921* / P27577* / ETS proto-oncogene 1, transcription factor*  / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction
 ENSGALG00000007097 RPS6KA6 / ribosomal protein S6 kinase A6 / Q9UK32* / ribosomal protein S6 kinase polypeptide 6*  / reaction
 ENSGALG00000005065 P49147 / PLA2G4A / Cytosolic phospholipase A2 Phospholipase A2 Lysophospholipase / P47713* / P47712* / phospholipase A2 group IVA* / phospholipase A2, group IVA (cytosolic, calcium-dependent)*  / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex / reaction
 ENSGALG00000008014 CEBPB / Q05826 / CCAAT/enhancer-binding protein beta / P17676* / P28033*  / reaction
 ENSGALG00000011505 MARK3 / microtubule affinity regulating kinase 3 / P27448* / Q03141* / MAP/microtubule affinity-regulating kinase 3 *  / complex / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / reaction / complex
 ENSGALG00000028543 FGFR4 / fibroblast growth factor receptor 4 / P22455*  / reaction
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / reaction
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction / complex
 ENSGALG00000042538 BAIAP2 / BAI1 associated protein 2 / Q8BKX1* / Q9UQB8* / Brain-specific angiosis inhibitor 1-associated protein 2 *  / reaction
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / reaction
 ENSGALG00000028037 FOS / P11939 / Proto-oncogene c-Fos / P01101* / P01100* / Proto-onco c-Fos * / Fos proto-oncogene, AP-1 transcription factor subunit*  / reaction
 ENSGALG00000028376 FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / reaction
 ENSGALG00000037136 P18652 / RPS6KA1L / Ribosomal protein S6 kinase 2 alpha / Q15418* / P18653* / RPS6KA1* / ribosomal protein S6 kinase A1* / ribosomal protein S6 kinase polypeptide 1*  / reaction
 ENSGALG00000009495 FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *  / reaction
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / reaction
 ENSGALG00000030580 Q5F3L1 / RPS6KA5 / Ribosomal protein S6 kinase alpha-5 / Q8C050* / O75582* / ribosomal protein S6 kinase A5* / ribosomal protein S6 kinase, polypeptide 5*  / reaction
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / complex / reaction
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSGALG00000015326 CLTA / clathrin light chain A / P09496*  / complex / reaction
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSGALG00000011419 DUSP4 / dual specificity protein phosphatase 4 / Q13115* / Q8BFV3* / dual specificity phosphatase 4*  / reaction
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex / reaction
 ENSGALG00000011207 DUSP6 / dual specificity protein phosphatase 6 / Q16828* / Q9DBB1* / dual specificity phosphatase 6*  / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSGALG00000035369 DUSP3 / dual specificity phosphatase 3 / P51452* / Q9D7X3* / Dual specificity protein phosphatase 3 *  / reaction
 ENSGALG00000041650 DUSP7 / Gallus gallus dual specificity phosphatase 7 (DUSP7), mRNA. / Q16829* / Q91Z46* / dual specificity phosphatase 7* / Dual specificity protein phosphatase 7 *  / reaction
 ENSGALG00000029881 LAMTOR2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 / Q9JHS3* / Q9Y2Q5* / Ragulator complex protein LAMTOR2 *  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / complex / reaction
 ENSGALG00000032618 DUSP5 / dual specificity phosphatase 5 / Q16690*  / reaction
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction






 

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