ENSGALG00000004143


Gallus gallus

Features
Gene ID: ENSGALG00000004143
  
Biological name :YWHAB
  
Synonyms : 14-3-3 protein beta/alpha / Q5ZLQ6 / YWHAB
  
Possible biological names infered from orthology : P31946 / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
  
Species: Gallus gallus
  
Chr. number: 20
Strand: -1
Band:
Gene start: 5388593
Gene end: 5401582
  
Corresponding Affymetrix probe sets: Gga.4816.1.A1_at (Chicken Array)   Gga.4816.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043305
NCBI entrez gene - 419190     See in Manteia.
RefSeq - NM_001006289
RefSeq Peptide - NP_001006289
swissprot - Q5ZLQ6
Ensembl - ENSGALG00000004143
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5PRD0ENSDARG00000013078Danio rerio
 ywhabbENSDARG00000075758Danio rerio
 YWHABENSG00000166913Homo sapiens
 YwhabENSMUSG00000018326Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YWHAZ / Q5ZKC9 / 14-3-3 protein zeta / P63104* / P63101* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...ENSGALG0000003138787
YWHAQ / Q5ZMD1 / 14-3-3 protein theta / P68254* / P27348* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta*ENSGALG0000001643377
YWHAG / 14-3-3 protein gamma / P61982* / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activ...ENSGALG0000001735876
YWHAH / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta / P68510* / Q04917* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide*ENSGALG0000000674375
SFN / stratifin / O70456* / P31947*ENSGALG0000002811569
YWHAE / Q5ZMT0 / 14-3-3 protein epsilon / P62259* / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon* / tyrosine 3-monooxygenase/tryptophan 5-monoox...ENSGALG0000000266167


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0035308 negative regulation of protein dephosphorylation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0051220 cytoplasmic sequestering of protein IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0050815 phosphoserine residue binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
mTOR signalling
mTORC1-mediated signalling
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007403 PEBP1 / phosphatidylethanolamine binding protein 1 / Pbp2* / P30086* / P70296*  / complex / reaction
 ENSGALG00000011505 MARK3 / microtubule affinity regulating kinase 3 / P27448* / Q03141* / MAP/microtubule affinity-regulating kinase 3 *  / complex / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / complex / reaction
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000003339 MTOR / mechanistic target of rapamycin kinase / P42345* / Q9JLN9* / Serine/threonine-protein kinase mTOR *  / complex / reaction
 ENSGALG00000005878 MLST8 / MTOR associated protein, LST8 homolog / Q9BVC4* / Q9DCJ1* / Target of rapamycin complex subunit LST8 *  / complex / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex / reaction
 ENSGALG00000014712 SLC38A9 / solute carrier family 38 member 9 / Q8BGD6* / Q8NBW4* / Sodium-coupled neutral amino acid transporter 9 *  / complex / reaction
 ENSGALG00000026971 RRAGD / Ras related GTP binding D / Q9NQL2*  / complex / reaction
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSGALG00000039228 ZFP36L1 / Gallus gallus ZFP36 ring finger protein like 1 (ZFP36L1), mRNA. / Q07352* / P23950* / ZFP36 ring finger protein like 1* / zinc finger protein 36, C3H type-like 1*  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / complex / reaction
 ENSGALG00000041226 RRAGB* / RRAGA* / Q7L523* / Q80X95* / Q5VZM2* / Q6NTA4* / Ras related GTP binding A* / Ras related GTP binding B* / Ras-related GTP-binding protein A * / Ras-related GTP-binding protein B *  / complex / reaction
 ENSGALG00000033885 RAP1GAP2 / rap1 GTPase-activating protein 2 / Q5SVL6* / Q684P5*  / complex / reaction






 

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