ENSDARG00000013078


Danio rerio

Features
Gene ID: ENSDARG00000013078
  
Biological name :ywhaba
  
Synonyms : Q5PRD0 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a / ywhaba
  
Possible biological names infered from orthology : P31946 / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / YWHAB
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 52212574
Gene end: 52225289
  
Corresponding Affymetrix probe sets: Dr.1368.3.S1_at (Zebrafish Array)   Dr.1368.3.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000027118
Ensembl peptide - ENSDARP00000122901
NCBI entrez gene - 323055     See in Manteia.
swissprot - E9QJ96
swissprot - Q5PRD0
ZFIN ID - ZDB-GENE-030131-6583
Ensembl - ENSDARG00000013078
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 YWHABENSGALG00000004143Gallus gallus
 YWHABENSG00000166913Homo sapiens
 YwhabENSMUSG00000018326Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ywhabb / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b / YWHAB* / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activa...ENSDARG0000007575893
ywhabl / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide likeENSDARG0000004028783
ywhaqa / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a / SFN* / YWHAQ* / P27348* / P31947* / P68254* / O70456* / stratifin* / tyrosine 3-monoox...ENSDARG0000004253982
ywhaqb / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b / SFN* / YWHAQ* / P27348* / P31947* / P68254* / O70456* / stratifin* / tyrosine 3-monoox...ENSDARG0000002332381
ywhaz / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideENSDARG0000003257577
ywhag2 / 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2 / YWHAG* / P61982* / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation pro...ENSDARG0000007165877
ywhag1 / Q6PC29 / 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1 / YWHAG* / P61982* / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activ...ENSDARG0000006762676
ywhah / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide / P68510* / Q04917* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta*ENSDARG0000000556070
ywhae1 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 / YWHAE* / P62259* / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase act...ENSDARG0000000639968
ywhae2 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2ENSDARG0000001701467


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006911 phagocytosis, engulfment IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
mTOR signalling
mTORC1-mediated signalling
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism decreased life span , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003167 mlst8 / Q803V5 / MTOR associated protein, LST8 homolog (S. cerevisiae) / Q9BVC4* / Q9DCJ1* / MTOR associated protein, LST8 homolog* / Target of rapamycin complex subunit LST8 *  / complex / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / complex / reaction
 ENSDARG00000017661 braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *  / complex / reaction
 ENSDARG00000021443 zfp36l1b / zinc finger protein 36, C3H type-like 1b / Q07352* / P23950* / ZFP36L1* / ZFP36 ring finger protein like 1* / zinc finger protein 36, C3H type-like 1*  / complex / reaction
 ENSDARG00000032769 Q08BA4 / slc38a9 / solute carrier family 38, member 9 / Q8NBW4*  / complex / reaction
 ENSDARG00000006609 map2k2a / mitogen-activated protein kinase kinase 2a / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...  / complex / reaction
 ENSDARG00000013078 ywhaba / Q5PRD0 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a / YWHAB* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activat...  / complex
 ENSDARG00000026630 mark3b / MAP/microtubule affinity-regulating kinase 3b / MARK1* / MARK3* / P27448* / Q9P0L2* / Q8VHJ5* / Q03141* / Serine/threonine-protein kinase MARK1 * / microtubule affinity regulating ...  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000016154 zfp36l1a / zinc finger protein 36, C3H type-like 1a / Q07352* / P23950* / ZFP36L1* / ZFP36 ring finger protein like 1* / zinc finger protein 36, C3H type-like 1*  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / complex / reaction
 ENSDARG00000042069 pebp1 / phosphatidylethanolamine binding protein 1 / Pbp2* / P30086* / P70296*  / complex / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / complex / reaction
 ENSDARG00000061551 rap1gap2a / RAP1 GTPase activating protein 2a / Q5SVL6* / Q684P5* / RAP1GAP2* / RAP1 GTPase activating protein 2*  / complex / reaction
 ENSDARG00000068401 yap1 / Q1L8J7 / Yes-associated protein 1 / P46937* / P46938*  / complex / reaction
 ENSDARG00000074667 akt1s1 / AKT1 substrate 1 (proline-rich) / Q96B36* / Q9D1F4* / AKT1 substrate 1* / Proline-rich AKT1 substrate 1 *  / complex / reaction
 ENSDARG00000098726 rptor / regulatory associated protein of MTOR, complex 1 / Q8N122*  / complex / reaction






 

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