ENSDARG00000017661


Danio rerio

Features
Gene ID: ENSDARG00000017661
  
Biological name :braf
  
Synonyms : braf / B-Raf proto-oncogene, serine/threonine kinase
  
Possible biological names infered from orthology : P15056 / P28028 / Serine/threonine-protein kinase B-raf
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 12074776
Gene end: 12102036
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000016253
Ensembl peptide - ENSDARP00000048390
NCBI entrez gene - 403065     See in Manteia.
swissprot - B3DFX5
swissprot - Q1LYG2
ZFIN ID - ZDB-GENE-040805-1
Ensembl - ENSDARG00000017661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BRAFENSGALG00000012865Gallus gallus
 BRAFENSG00000157764Homo sapiens
 BrafENSMUSG00000002413Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
araf / A-Raf proto-oncogene, serine/threonine kinase / P04627* / P10398* / Serine/threonine-protein kinase A-Raf *ENSDARG0000005453344
raf1b / Raf-1 proto-oncogene, serine/threonine kinase b / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG0000005940644
raf1a / Raf-1 proto-oncogene, serine/threonine kinase a / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG0000009641543
ksr1b / kinase suppressor of ras 1b / KSR1* / Q61097* / Q8IVT5* / kinase suppressor of ras 1* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSDARG0000003093321
ksr1a / kinase suppressor of ras 1a / KSR1* / Q61097* / Q8IVT5* / kinase suppressor of ras 1* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSDARG0000006871421
ksr2 / kinase suppressor of ras 2 / Q6VAB6*ENSDARG0000009452621
raf1a / Raf-1 proto-oncogene, serine/threonine kinase a / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG0000010232811
si:ch73-263f13.1 / KSR2* / Q6VAB6* / kinase suppressor of ras 2*ENSDARG000000941721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Spry regulation of FGF signaling
CREB phosphorylation through the activation of Ras
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006609 map2k2a / mitogen-activated protein kinase kinase 2a / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...  / complex / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / complex / reaction
 ENSDARG00000017661 braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *  / complex / reaction
 ENSDARG00000006553 rras / RAS related / P10301* / P10833* / related RAS viral (r-ras) oncogene*  / complex
 ENSDARG00000013078 ywhaba / Q5PRD0 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a / YWHAB* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activat...  / complex / reaction
 ENSDARG00000026630 mark3b / MAP/microtubule affinity-regulating kinase 3b / MARK1* / MARK3* / P27448* / Q9P0L2* / Q8VHJ5* / Q03141* / Serine/threonine-protein kinase MARK1 * / microtubule affinity regulating ...  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000078308 spry2 / sprouty RTK signaling antagonist 2 / O43597* / Q9QXV8*  / complex
 ENSDARG00000039872 lamtor2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 / Q9JHS3* / Q9Y2Q5* / Ragulator complex protein LAMTOR2 *  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / complex / reaction
 ENSDARG00000057075 lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / O88653* / Q9UHA4*  / complex / reaction
 ENSDARG00000017703 paqr3a / progestin and adipoQ receptor family member IIIa / PAQR3* / Q6TCH7* / Q6TCG8* / progestin and adipoQ receptor family member 3* / progestin and adipoQ receptor family member III*  / complex / reaction
 ENSDARG00000044253 paqr3b / progestin and adipoQ receptor family member IIIb / PAQR3* / Q6TCH7* / Q6TCG8* / progestin and adipoQ receptor family member 3* / progestin and adipoQ receptor family member III*  / complex / reaction
 ENSDARG00000043010 Q6DEH3 / camk2d1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / CAMK2D* / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus c...  / reaction
 ENSDARG00000042069 pebp1 / phosphatidylethanolamine binding protein 1 / Pbp2* / P30086* / P70296*  / complex / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / complex / reaction






 

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