ENSDARG00000096415


Danio rerio

Features
Gene ID: ENSDARG00000096415
  
Biological name :raf1a
  
Synonyms : raf1a / Raf-1 proto-oncogene, serine/threonine kinase a
  
Possible biological names infered from orthology : Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049 / Q99N57 / RAF1 / Raf-1 proto-oncogene, serine/threonine kinase
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 4709607
Gene end: 4747277
  
Corresponding Affymetrix probe sets: Dr.27.1.S1_a_at (Zebrafish Array)   NM_131439_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000115152
Ensembl peptide - ENSDARP00000137636
Ensembl peptide - ENSDARP00000132202
Ensembl peptide - ENSDARP00000130779
NCBI entrez gene - 30716     See in Manteia.
RefSeq - NM_131439
RefSeq - XM_017353507
RefSeq Peptide - NP_571514
swissprot - A0A0R4IC22
swissprot - F1QAD4
swissprot - A0A0R4IYG8
swissprot - A0A0R4IN14
swissprot - A0A0R4IC76
ZFIN ID - ZDB-GENE-990415-41
Ensembl - ENSDARG00000096415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAF1ENSGALG00000004998Gallus gallus
 RAF1ENSG00000132155Homo sapiens
 Raf1ENSMUSG00000000441Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
raf1b / Raf-1 proto-oncogene, serine/threonine kinase b / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG0000005940674
araf / A-Raf proto-oncogene, serine/threonine kinase / P04627* / P10398* / Serine/threonine-protein kinase A-Raf *ENSDARG0000005453355
braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *ENSDARG0000001766154
raf1a / Raf-1 proto-oncogene, serine/threonine kinase a / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG0000010232828
ksr2 / kinase suppressor of ras 2 / Q6VAB6*ENSDARG0000009452624
ksr1b / kinase suppressor of ras 1b / KSR1* / Q61097* / Q8IVT5* / kinase suppressor of ras 1* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSDARG0000003093323
ksr1a / kinase suppressor of ras 1a / KSR1* / Q61097* / Q8IVT5* / kinase suppressor of ras 1* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSDARG0000006871423
si:ch73-263f13.1 / KSR2* / Q6VAB6* / kinase suppressor of ras 2*ENSDARG000000941721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rap1 signalling
GP1b-IX-V activation signalling
CREB phosphorylation through the activation of Ras
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium increased size , abnormal
Show

 ZFA:0000114 heart heart malformed , abnormal
Show

 ZFA:0000471 atrium atrium increased thickness , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curvature , abnormal
Show

 ZFA:0001617 otolith otolith position , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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