ENSDARG00000054533


Danio rerio

Features
Gene ID: ENSDARG00000054533
  
Biological name :araf
  
Synonyms : araf / A-Raf proto-oncogene, serine/threonine kinase
  
Possible biological names infered from orthology : P04627 / P10398 / Serine/threonine-protein kinase A-Raf
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 26856253
Gene end: 26869392
  
Corresponding Affymetrix probe sets: Dr.23162.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000071167
Ensembl peptide - ENSDARP00000135192
Ensembl peptide - ENSDARP00000118701
Ensembl peptide - ENSDARP00000118602
Ensembl peptide - ENSDARP00000112713
Ensembl peptide - ENSDARP00000071158
NCBI entrez gene - 403063     See in Manteia.
RefSeq - XM_005171817
swissprot - A0A0A1GVY9
swissprot - A0A0A1GUM7
swissprot - A0A0A1GQF3
swissprot - F1QBH1
swissprot - F6NIM6
swissprot - Q5FBD1
swissprot - Q5M7Y2
swissprot - A0A0B4J1B1
ZFIN ID - ZDB-GENE-050102-2
Ensembl - ENSDARG00000054533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARAFENSG00000078061Homo sapiens
 ArafENSMUSG00000001127Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *ENSDARG0000001766160
raf1b / Raf-1 proto-oncogene, serine/threonine kinase b / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG0000005940660
raf1a / Raf-1 proto-oncogene, serine/threonine kinase a / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG0000009641560
ksr2 / kinase suppressor of ras 2 / Q6VAB6*ENSDARG0000009452625
ksr1a / kinase suppressor of ras 1a / KSR1* / Q61097* / Q8IVT5* / kinase suppressor of ras 1* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSDARG0000006871423
ksr1b / kinase suppressor of ras 1b / KSR1* / Q61097* / Q8IVT5* / kinase suppressor of ras 1* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSDARG0000003093322
raf1a / Raf-1 proto-oncogene, serine/threonine kinase a / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG0000010232816
si:ch73-263f13.1 / KSR2* / Q6VAB6* / kinase suppressor of ras 2*ENSDARG000000941720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:1900108 negative regulation of nodal signaling pathway IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0046332 SMAD binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000038 margin margin increased thickness , abnormal
Show

 ZFA:0000117 hypoblast hypoblast has extra parts of type somatic stem cell , abnormal
Show

 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism dorsal region increased distribution , abnormal
whole organism ventral region decreased distribution , abnormal
Show

 ZFA:0001120 neuroectoderm neuroectoderm anterior region increased distribution , abnormal
neuroectoderm posterior region increased distribution , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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