ENSDARG00000003167


Danio rerio

Features
Gene ID: ENSDARG00000003167
  
Biological name :mlst8
  
Synonyms : mlst8 / MTOR associated protein, LST8 homolog (S. cerevisiae) / Q803V5
  
Possible biological names infered from orthology : MTOR associated protein, LST8 homolog / Q9BVC4 / Q9DCJ1 / Target of rapamycin complex subunit LST8
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 18542954
Gene end: 18571563
  
Corresponding Affymetrix probe sets: Dr.18622.1.A1_at (Zebrafish Array)   Dr.7298.1.S1_at (Zebrafish Array)   Dr.8365.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000118004
Ensembl peptide - ENSDARP00000151016
Ensembl peptide - ENSDARP00000144316
Ensembl peptide - ENSDARP00000137020
Ensembl peptide - ENSDARP00000019416
Ensembl peptide - ENSDARP00000115056
NCBI entrez gene - 792689     See in Manteia.
RefSeq - NM_001320388
RefSeq Peptide - NP_001307317
swissprot - B2GPI2
swissprot - A0A0R4IPN3
swissprot - E9QHM2
swissprot - Q803V5
ZFIN ID - ZDB-GENE-030131-6176
Ensembl - ENSDARG00000003167
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MLST8ENSGALG00000005878Gallus gallus
 MLST8ENSG00000167965Homo sapiens
 Mlst8ENSMUSG00000024142Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031929 TOR signaling IBA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0031931 TORC1 complex IBA
 cellular_componentGO:0031932 TORC2 complex IBA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003167 mlst8 / Q803V5 / MTOR associated protein, LST8 homolog (S. cerevisiae) / Q9BVC4* / Q9DCJ1* / MTOR associated protein, LST8 homolog* / Target of rapamycin complex subunit LST8 *  / complex
 ENSDARG00000013078 ywhaba / Q5PRD0 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a / YWHAB* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activat...  / complex / reaction
 ENSDARG00000036040 atg13 / Q7SYE0 / ATG13 autophagy related 13 homolog (S. cerevisiae) / Q91YI1* / O75143* / autophagy related 13* / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA.*  / complex / reaction
 ENSDARG00000043287 atg101 / Q3B736 / autophagy related 101 / Q9BSB4* / Q9D8Z6* / Autophagy-related protein 101 *  / complex / reaction
 ENSDARG00000076559 rb1cc1 / RB1-inducible coiled-coil 1 / Q8TDY2*  / complex / reaction
 ENSDARG00000036489 zgc:112356 / MAF1* / Q9D0U6* / Q9H063* / MAF1 homolog, negative regulator of RNA polymerase III* / Repressor of RNA polymerase III transcription MAF1 homolog *  / reaction
 ENSDARG00000074481 ulk1b / unc-51 like autophagy activating kinase 1 / ULK1* / O75385* / unc-51 like kinase 1*  / complex / reaction
 ENSDARG00000074667 akt1s1 / AKT1 substrate 1 (proline-rich) / Q96B36* / Q9D1F4* / AKT1 substrate 1* / Proline-rich AKT1 substrate 1 *  / complex / reaction
 ENSDARG00000098726 rptor / regulatory associated protein of MTOR, complex 1 / Q8N122*  / complex
 ENSDARG00000017537 prkag3a / protein kinase, AMP-activated, gamma 3a non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / reaction
 ENSDARG00000003818 prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / O54950* / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction
 ENSDARG00000032769 Q08BA4 / slc38a9 / solute carrier family 38, member 9 / Q8NBW4*  / complex / reaction
 ENSDARG00000046143 prkab1b / protein kinase, AMP-activated, beta 1 non-catalytic subunit, b / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / reaction
 ENSDARG00000060596 prkaa1 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / Q5EG47* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSDARG00000060641 prkaa2 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSDARG00000044183 prkab1a / protein kinase, AMP-activated, beta 1 non-catalytic subunit, a / PRKAB1* / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-act...  / reaction
 ENSDARG00000067817 CABZ01083448.1 / O43741* / PRKAB2* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSDARG00000000369 prkag3b / protein kinase, AMP-activated, gamma 3b non-catalytic subunit / Q9UGI9* / PRKAG3* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-act...  / reaction






 

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