ENSGALG00000005878


Gallus gallus

Features
Gene ID: ENSGALG00000005878
  
Biological name :MLST8
  
Synonyms : MLST8 / MTOR associated protein, LST8 homolog
  
Possible biological names infered from orthology : Q9BVC4 / Q9DCJ1 / Target of rapamycin complex subunit LST8
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 6522087
Gene end: 6527020
  
Corresponding Affymetrix probe sets: GgaAffx.3670.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009432
NCBI entrez gene - 416558     See in Manteia.
RefSeq - XM_004945247
swissprot - F1NAZ4
Ensembl - ENSGALG00000005878
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mlst8ENSDARG00000003167Danio rerio
 MLST8ENSG00000167965Homo sapiens
 Mlst8ENSMUSG00000024142Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031929 TOR signaling IBA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0038202 TORC1 signaling IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0031931 TORC1 complex IBA
 cellular_componentGO:0031932 TORC2 complex IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001678 PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2 / O43741* / Q6PAM0* / protein kinase, AMP-activated, beta 2 non-catalytic subunit*  / reaction
 ENSGALG00000003339 MTOR / mechanistic target of rapamycin kinase / P42345* / Q9JLN9* / Serine/threonine-protein kinase mTOR *  / complex
 ENSGALG00000005878 MLST8 / MTOR associated protein, LST8 homolog / Q9BVC4* / Q9DCJ1* / Target of rapamycin complex subunit LST8 *  / complex
 ENSGALG00000008347 ATG13 / autophagy related 13 / O75143* / Q91YI1* / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA.*  / complex / reaction
 ENSGALG00000015259 RB1CC1 / RB1 inducible coiled-coil 1 / Q8TDY2* / Q9ESK9* / RB1-inducible coiled-coil protein 1 *  / complex / reaction
 ENSGALG00000007373 PRKAB1 / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-activated, beta 1 non-catalytic subunit*  / reaction
 ENSGALG00000014712 SLC38A9 / solute carrier family 38 member 9 / Q8BGD6* / Q8NBW4* / Sodium-coupled neutral amino acid transporter 9 *  / complex / reaction
 ENSGALG00000014832 PRKAA1 / protein kinase AMP-activated catalytic subunit alpha 1 / Q13131* / Q5EG47* / protein kinase, AMP-activated, alpha 1 catalytic subunit*  / reaction
 ENSGALG00000010826 PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2 / P54646* / Q8BRK8* / protein kinase, AMP-activated, alpha 2 catalytic subunit*  / reaction
 ENSGALG00000011360 PRKAG3 / 5-AMP-activated protein kinase subunit gamma-3 / Q9UGI9* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-activated, gamma 3 non-catat...  / reaction
 ENSGALG00000026971 RRAGD / Ras related GTP binding D / Q9NQL2*  / complex / reaction
 ENSGALG00000036282 O54950* / P54619* / PRKAG1* / protein kinase AMP-activated non-catalytic subunit gamma 1* / protein kinase, AMP-activated, gamma 1 non-catalytic subunit*  / reaction
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex / reaction
 ENSGALG00000041226 RRAGB* / RRAGA* / Q7L523* / Q80X95* / Q5VZM2* / Q6NTA4* / Ras related GTP binding A* / Ras related GTP binding B* / Ras-related GTP-binding protein A * / Ras-related GTP-binding protein B *  / complex / reaction






 

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