ENSGALG00000003339


Gallus gallus

Features
Gene ID: ENSGALG00000003339
  
Biological name :MTOR
  
Synonyms : mechanistic target of rapamycin kinase / MTOR
  
Possible biological names infered from orthology : P42345 / Q9JLN9 / Serine/threonine-protein kinase mTOR
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 4129577
Gene end: 4190653
  
Corresponding Affymetrix probe sets: Gga.11732.1.S1_at (Chicken Array)   GgaAffx.1955.1.S1_at (Chicken Array)   GgaAffx.2006.1.S1_at (Chicken Array)   GgaAffx.2082.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005274
Ensembl peptide - ENSGALP00000048903
NCBI entrez gene - 419455     See in Manteia.
RefSeq - XM_417614
swissprot - A0A1D5P858
swissprot - F1NUX4
Ensembl - ENSGALG00000003339
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtorENSDARG00000053196Danio rerio
 MTORENSG00000198793Homo sapiens
 MtorENSMUSG00000028991Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMG1 / SMG1, nonsense mediated mRNA decay associated PI3K related kinase / Q8BKX6* / Q96Q15* / Serine/threonine-protein kinase SMG1 *ENSGALG0000000682917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR009076  FKBP12-rapamycin binding domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR014009  PIK-related kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR024585  Domain of unknown function DUF3385, target of rapamycin protein
 IPR026683  Serine/threonine-protein kinase TOR


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003179 heart valve morphogenesis IEA
 biological_processGO:0006112 energy reserve metabolic process IEA
 biological_processGO:0006207 "de novo" pyrimidine nucleobase biosynthetic process IEA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010831 positive regulation of myotube differentiation IEA
 biological_processGO:0016242 negative regulation of macroautophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031529 ruffle organization IEA
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0031669 cellular response to nutrient levels IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0038202 TORC1 signaling IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0045670 regulation of osteoclast differentiation IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045792 negative regulation of cell size IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0048738 cardiac muscle tissue development IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050882 voluntary musculoskeletal movement IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051549 positive regulation of keratinocyte migration IEA
 biological_processGO:0051896 regulation of protein kinase B signaling IEA
 biological_processGO:0055006 cardiac cell development IEA
 biological_processGO:0055013 cardiac muscle cell development IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071233 cellular response to leucine IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090559 regulation of membrane permeability IEA
 biological_processGO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IEA
 biological_processGO:1903691 positive regulation of wound healing, spreading of epidermal cells IEA
 biological_processGO:1990253 cellular response to leucine starvation IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031931 TORC1 complex IEA
 cellular_componentGO:0031932 TORC2 complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001030 RNA polymerase III type 1 promoter DNA binding IEA
 molecular_functionGO:0001031 RNA polymerase III type 2 promoter DNA binding IEA
 molecular_functionGO:0001032 RNA polymerase III type 3 promoter DNA binding IEA
 molecular_functionGO:0001156 TFIIIC-class transcription factor binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001678 PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2 / O43741* / Q6PAM0* / protein kinase, AMP-activated, beta 2 non-catalytic subunit*  / reaction
 ENSGALG00000003205 EIF4EBP1 / eukaryotic translation initiation factor 4E binding protein 1 / Q13541* / Q60876*  / reaction
 ENSGALG00000003339 MTOR / mechanistic target of rapamycin kinase / P42345* / Q9JLN9* / Serine/threonine-protein kinase mTOR *  / complex
 ENSGALG00000005198 RPS6KB1 / ribosomal protein S6 kinase beta-1 / P23443* / Q8BSK8* / ribosomal protein S6 kinase B1* / ribosomal protein S6 kinase, polypeptide 1*  / reaction
 ENSGALG00000008347 ATG13 / autophagy related 13 / O75143* / Q91YI1* / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA.*  / complex / reaction
 ENSGALG00000015259 RB1CC1 / RB1 inducible coiled-coil 1 / Q8TDY2* / Q9ESK9* / RB1-inducible coiled-coil protein 1 *  / complex / reaction
 ENSGALG00000013971 SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*  / reaction
 ENSGALG00000042112 EIF4E / eukaryotic translation initiation factor 4E / P06730* / P63073*  / reaction
 ENSGALG00000005878 MLST8 / MTOR associated protein, LST8 homolog / Q9BVC4* / Q9DCJ1* / Target of rapamycin complex subunit LST8 *  / complex
 ENSGALG00000007373 PRKAB1 / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-activated, beta 1 non-catalytic subunit*  / reaction
 ENSGALG00000014712 SLC38A9 / solute carrier family 38 member 9 / Q8BGD6* / Q8NBW4* / Sodium-coupled neutral amino acid transporter 9 *  / complex / reaction
 ENSGALG00000014832 PRKAA1 / protein kinase AMP-activated catalytic subunit alpha 1 / Q13131* / Q5EG47* / protein kinase, AMP-activated, alpha 1 catalytic subunit*  / reaction
 ENSGALG00000010826 PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2 / P54646* / Q8BRK8* / protein kinase, AMP-activated, alpha 2 catalytic subunit*  / reaction
 ENSGALG00000011360 PRKAG3 / 5-AMP-activated protein kinase subunit gamma-3 / Q9UGI9* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-activated, gamma 3 non-catat...  / reaction
 ENSGALG00000026971 RRAGD / Ras related GTP binding D / Q9NQL2*  / complex / reaction
 ENSGALG00000036282 O54950* / P54619* / PRKAG1* / protein kinase AMP-activated non-catalytic subunit gamma 1* / protein kinase, AMP-activated, gamma 1 non-catalytic subunit*  / reaction
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex / reaction
 ENSGALG00000041226 RRAGB* / RRAGA* / Q7L523* / Q80X95* / Q5VZM2* / Q6NTA4* / Ras related GTP binding A* / Ras related GTP binding B* / Ras-related GTP-binding protein A * / Ras-related GTP-binding protein B *  / complex / reaction






 

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