ENSGALG00000005198


Gallus gallus

Features
Gene ID: ENSGALG00000005198
  
Biological name :RPS6KB1
  
Synonyms : ribosomal protein S6 kinase beta-1 / RPS6KB1
  
Possible biological names infered from orthology : P23443 / Q8BSK8 / ribosomal protein S6 kinase B1 / ribosomal protein S6 kinase, polypeptide 1
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 7391599
Gene end: 7403922
  
Corresponding Affymetrix probe sets: GgaAffx.11722.1.S1_s_at (Chicken Array)   GgaAffx.20928.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000008334
NCBI entrez gene - 417637     See in Manteia.
RefSeq - NM_001030721
RefSeq - XM_015295787
RefSeq Peptide - NP_001025892
swissprot - F1P4J0
Ensembl - ENSGALG00000005198
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6kb1aENSDARG00000018399Danio rerio
 rps6kb1bENSDARG00000058230Danio rerio
 P23443ENSG00000108443Homo sapiens
 Q8BSK8ENSMUSG00000020516Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RPS6KA3 / ribosomal protein S6 kinase A3 / P18654* / P51812* / ribosomal protein S6 kinase polypeptide 3*ENSGALG0000001640643
RPS6KA6 / ribosomal protein S6 kinase A6 / Q9UK32* / ribosomal protein S6 kinase polypeptide 6*ENSGALG0000000709742
RPS6KA2 / ribosomal protein S6 kinase A2 / Q15349* / Q9WUT3* / ribosomal protein S6 kinase, polypeptide 2*ENSGALG0000001147342
P18652 / RPS6KA1L / Ribosomal protein S6 kinase 2 alpha / Q15418* / P18653* / RPS6KA1* / ribosomal protein S6 kinase A1* / ribosomal protein S6 kinase polypeptide 1*ENSGALG0000003713642
Q5F3L1 / RPS6KA5 / Ribosomal protein S6 kinase alpha-5 / Q8C050* / O75582* / ribosomal protein S6 kinase A5* / ribosomal protein S6 kinase, polypeptide 5*ENSGALG0000003058040
STK32C / serine/threonine kinase 32C / Q86UX6* / Q8QZV4* / Serine/threonine-protein kinase 32C *ENSGALG0000002061521
STK32A / serine/threonine kinase 32A / Q8BGW6* / Q8WU08* / Serine/threonine-protein kinase 32A *ENSGALG0000002919521
STK32B / serine/threonine kinase 32B / Q9JJX8* / Q9NY57* / Serine/threonine-protein kinase 32B *ENSGALG0000002951021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016238  Ribosomal protein S6 kinase
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045948 positive regulation of translational initiation IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003339 MTOR / mechanistic target of rapamycin kinase / P42345* / Q9JLN9* / Serine/threonine-protein kinase mTOR *  / reaction
 ENSGALG00000008520 EIF4G1 / eukaryotic translation initiation factor 4 gamma 1 / Q04637* / Q6NZJ6*  / reaction






 

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