ENSG00000166913


Homo sapiens
proteinYWHABsignalingbinding-regulationactivationmembraneactivitybrafdomainmapkmrnapathwaysignallingrafmutantshippotranscriptioncytoplasmiccytoplasmcomplextranslocation-mediatedbindsdestabilizeskinasechkconservedsitesuperfamily

Features
Gene ID: ENSG00000166913
  
Biological name :YWHAB
  
Synonyms : P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta / YWHAB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.12
Gene start: 44885676
Gene end: 44908532
  
Corresponding Affymetrix probe sets: 208743_s_at (Human Genome U133 Plus 2.0 Array)   217717_s_at (Human Genome U133 Plus 2.0 Array)   217718_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394729
Ensembl peptide - ENSP00000394558
Ensembl peptide - ENSP00000487924
Ensembl peptide - ENSP00000488178
Ensembl peptide - ENSP00000300161
Ensembl peptide - ENSP00000361930
NCBI entrez gene - 7529     See in Manteia.
OMIM - 601289
RefSeq - XM_017028040
RefSeq - NM_003404
RefSeq - NM_139323
RefSeq - XM_017028039
RefSeq Peptide - NP_003395
RefSeq Peptide - NP_647539
swissprot - P31946
swissprot - Q4VY19
swissprot - Q4VY20
swissprot - A0A0J9YWZ2
swissprot - V9HWD6
swissprot - A0A0J9YWE8
Ensembl - ENSG00000166913
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5PRD0ENSDARG00000013078Danio rerio
 ywhabbENSDARG00000075758Danio rerio
 YWHABENSGALG00000004143Gallus gallus
 YwhabENSMUSG00000018326Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zetaENSG0000016492487
YWHAQ / P27348 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaENSG0000013430881
YWHAH / Q04917 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaENSG0000012824575
YWHAG / P61981 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gammaENSG0000017002775
SFN / P31947 / stratifinENSG0000017579367
YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonENSG0000010895366


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismsregulation of molecular functioncatabolic processregulation of biological qualitybiosynthetic processcellular component organizationcellular component biogenesiscell deathnitrogennitrogen compound metabolic processcell comcell communicationcellularcellular metabolic processprimary primary metabolic processorganic organic substance metabolic processcellularcellular response to stimulusmacromolmacromolecule localizationestablisestablishment of localizationcellularcellular localizationinterspeinterspecies interaction between organismsregulatiregulation of molecular functioncatabolicatabolic processregulatiregulation of biological qualitybiosynthbiosynthetic processcellularcellular component organizationcellularcellular component biogenesiscell deacell death
transcription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activitytranscription coregulator activityprotein bindingprotein binding
cellorganellecell junctionmembraneprotein-containing complexextracellular regioncellorganellecell junctionmembraneprotein-containing complexextracellular regioncellorganellecell junctionmembraneprotein-containing complexextracellular regioncellorganellecell junctionmembraneprotein-containing complexextracellular regioncellorganellecell junctionmembraneprotein-containing complexextracellular regioncellorganellecell junctionmembraneprotein-containing complexextracellular regioncellorganellecell junctionmembraneprotein-containing complexextracellular regioncellorganellecell junctionmembraneprotein-containing complexextracellular regioncellorganellecell junctionmembraneprotein-containing complexextracellular regioncellorganellecell junctionmembraneprotein-containing complexextracellular regioncellcellorganelleorganellecell junctioncell junctionmembranemembraneprotein-containing compprotein-containing complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0035308 negative regulation of protein dephosphorylation IDA
 biological_processGO:0035329 hippo signaling TAS
 biological_processGO:0043085 positive regulation of catalytic activity IDA
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0051220 cytoplasmic sequestering of protein IDA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0050815 phosphoserine residue binding IPI
 molecular_functionGO:0051219 phosphoprotein binding IPI


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
mTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000011485 PPP5C / P53041 / protein phosphatase 5 catalytic subunit  / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / complex / reaction
 ENSG00000075413 MARK3 / P27448 / microtubule affinity regulating kinase 3  / complex / reaction
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / complex / reaction
 ENSG00000126934 MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2  / complex / reaction
 ENSG00000089220 PEBP1 / P30086 / phosphatidylethanolamine binding protein 1  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / complex / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / complex / reaction
 ENSG00000078061 ARAF / P10398 / A-Raf proto-oncogene, serine/threonine kinase  / complex / reaction
 ENSG00000137693 YAP1 / P46937 / Yes associated protein 1  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / complex / reaction
 ENSG00000141068 KSR1 / Q8IVT5 / kinase suppressor of ras 1  / complex / reaction
 ENSG00000169032 MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1  / complex / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / complex / reaction
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / complex / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / complex / reaction
 ENSG00000134313 Q9ULH0 / KIDINS220 / kinase D interacting substrate 220  / complex / reaction
 ENSG00000132359 Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2  / complex / reaction
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / complex / reaction
 ENSG00000204673 AKT1S1 / Q96B36 / AKT1 substrate 1  / complex / reaction
 ENSG00000083312 TNPO1 / Q92973 / transportin 1  / complex / reaction
 ENSG00000185650 Q07352 / ZFP36L1 / ZFP36 ring finger protein like 1  / complex / reaction
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / complex / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / complex
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / complex / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / complex / reaction
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / complex / reaction
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / complex / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / complex / reaction






 

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