Manteia

ENSG00000102882

Homo sapiens

Features

Gene ID:	ENSG00000102882

Biological name :	MAPK3

Synonyms :	MAPK3 / mitogen-activated protein kinase 3 / P27361

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	16
Strand:	-1
Band:	p11.2
Gene start:	30114105
Gene end:	30123506

Corresponding Affymetrix probe sets:	212046_x_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000378628 Ensembl peptide - ENSP00000436772 Ensembl peptide - ENSP00000433746 Ensembl peptide - ENSP00000433639 Ensembl peptide - ENSP00000432742 Ensembl peptide - ENSP00000432479 Ensembl peptide - ENSP00000432292 Ensembl peptide - ENSP00000263025 Ensembl peptide - ENSP00000327293 Ensembl peptide - ENSP00000378625 Ensembl peptide - ENSP00000378626 NCBI entrez gene - 5595 See in Manteia. OMIM - 601795 RefSeq - NM_001109891 RefSeq - NM_002746 RefSeq - NM_001040056 RefSeq Peptide - NP_001035145 RefSeq Peptide - NP_001103361 RefSeq Peptide - NP_002737 swissprot - L7RXH5 swissprot - E9PRH7 swissprot - P27361 swissprot - E9PQW4 swissprot - E9PJF0 swissprot - E9PBK7 swissprot - B3KR49 swissprot - H0YDH9 swissprot - H0YEX6 Ensembl - ENSG00000102882

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mapk3	ENSDARG00000070573	Danio rerio
Mapk3	ENSMUSG00000063065	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
MAPK1 / P28482 / mitogen-activated protein kinase 1	ENSG00000100030	82
MAPK7 / Q13164 / mitogen-activated protein kinase 7	ENSG00000166484	48
MAPK6 / Q16659 / mitogen-activated protein kinase 6	ENSG00000069956	40
NLK / Q9UBE8 / nemo like kinase	ENSG00000087095	40
MAPK4 / P31152 / mitogen-activated protein kinase 4	ENSG00000141639	37
MAPK15 / Q8TD08 / mitogen-activated protein kinase 15	ENSG00000181085	37

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
IPR008271	Serine/threonine-protein kinase, active site
IPR008349	Mitogen-activated protein (MAP) kinase, ERK1/2
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	NAS
biological_process	GO:0000187	activation of MAPK activity	TAS
biological_process	GO:0001934	positive regulation of protein phosphorylation	IMP
biological_process	GO:0002741	positive regulation of cytokine secretion involved in immune response	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006361	transcription initiation from RNA polymerase I promoter	TAS
biological_process	GO:0006468	protein phosphorylation	IDA
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0006975	DNA damage induced protein phosphorylation	IDA
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007411	axon guidance	TAS
biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	TAS
biological_process	GO:0009636	response to toxic substance	IEA
biological_process	GO:0009887	animal organ morphogenesis	IEA
biological_process	GO:0010628	positive regulation of gene expression	IMP
biological_process	GO:0010759	positive regulation of macrophage chemotaxis	IEA
biological_process	GO:0014032	neural crest cell development	IEA
biological_process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	TAS
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018105	peptidyl-serine phosphorylation	IEA
biological_process	GO:0019233	sensory perception of pain	IEA
biological_process	GO:0019369	arachidonic acid metabolic process	IEA
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0030278	regulation of ossification	IEA
biological_process	GO:0030509	BMP signaling pathway	IMP
biological_process	GO:0030641	regulation of cellular pH	IEA
biological_process	GO:0030878	thyroid gland development	IEA
biological_process	GO:0031281	positive regulation of cyclase activity	IMP
biological_process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IEA
biological_process	GO:0032212	positive regulation of telomere maintenance via telomerase	IMP
biological_process	GO:0032496	response to lipopolysaccharide	IEA
biological_process	GO:0032872	regulation of stress-activated MAPK cascade	TAS
biological_process	GO:0033129	positive regulation of histone phosphorylation	IMP
biological_process	GO:0034198	cellular response to amino acid starvation	IDA
biological_process	GO:0034614	cellular response to reactive oxygen species	IMP
biological_process	GO:0035066	positive regulation of histone acetylation	IMP
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	IDA
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0042473	outer ear morphogenesis	IEA
biological_process	GO:0043330	response to exogenous dsRNA	IEA
biological_process	GO:0045727	positive regulation of translation	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0048538	thymus development	IEA
biological_process	GO:0051090	regulation of DNA-binding transcription factor activity	TAS
biological_process	GO:0051216	cartilage development	IEA
biological_process	GO:0051403	stress-activated MAPK cascade	IDA
biological_process	GO:0051493	regulation of cytoskeleton organization	TAS
biological_process	GO:0051973	positive regulation of telomerase activity	IMP
biological_process	GO:0060020	Bergmann glial cell differentiation	IEA
biological_process	GO:0060324	face development	IEA
biological_process	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	TAS
biological_process	GO:0060425	lung morphogenesis	IEA
biological_process	GO:0060440	trachea formation	IEA
biological_process	GO:0061308	cardiac neural crest cell development involved in heart development	IEA
biological_process	GO:0065003	protein-containing complex assembly	IEA
biological_process	GO:0070371	ERK1 and ERK2 cascade	IEA
biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP
biological_process	GO:0070498	interleukin-1-mediated signaling pathway	IMP
biological_process	GO:0070849	response to epidermal growth factor	IDA
biological_process	GO:0071260	cellular response to mechanical stimulus	IEP
biological_process	GO:0071276	cellular response to cadmium ion	IMP
biological_process	GO:0071356	cellular response to tumor necrosis factor	IEA
biological_process	GO:0072584	caveolin-mediated endocytosis	TAS
biological_process	GO:0090170	regulation of Golgi inheritance	TAS
biological_process	GO:1900034	regulation of cellular response to heat	TAS
biological_process	GO:1903351	cellular response to dopamine	IMP
biological_process	GO:1904355	positive regulation of telomere capping	IMP
biological_process	GO:1904417	positive regulation of xenophagy	IEA
biological_process	GO:1905050	positive regulation of metallopeptidase activity	IEA
biological_process	GO:2000641	regulation of early endosome to late endosome transport	TAS
biological_process	GO:2000657	negative regulation of apolipoprotein binding	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	TAS
cellular_component	GO:0005635	nuclear envelope	IDA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005739	mitochondrion	TAS
cellular_component	GO:0005769	early endosome	TAS
cellular_component	GO:0005770	late endosome	TAS
cellular_component	GO:0005794	Golgi apparatus	TAS
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005856	cytoskeleton	TAS
cellular_component	GO:0005886	plasma membrane	ISS
cellular_component	GO:0005901	caveola	TAS
cellular_component	GO:0005925	focal adhesion	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031143	pseudopodium	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0001784	phosphotyrosine residue binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	TAS
molecular_function	GO:0004707	MAP kinase activity	TAS
molecular_function	GO:0004708	MAP kinase kinase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	TAS
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019902	phosphatase binding	IPI
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0097110	scaffold protein binding	IEA

Pathways (from Reactome)

Pathway description

MAPK3 (ERK1) activation

RAF-independent MAPK1/3 activation

ISG15 antiviral mechanism

Spry regulation of FGF signaling

ERK/MAPK targets

ERKs are inactivated

Regulation of actin dynamics for phagocytic cup formation

Oxidative Stress Induced Senescence

Senescence-Associated Secretory Phenotype (SASP)

Oncogene Induced Senescence

FCERI mediated MAPK activation

Regulation of HSF1-mediated heat shock response

NCAM signaling for neurite out-growth

Signal transduction by L1

Activation of the AP-1 family of transcription factors

Thrombin signalling through proteinase activated receptors (PARs)

Negative regulation of FGFR1 signaling

Negative regulation of FGFR2 signaling

Negative regulation of FGFR3 signaling

Negative regulation of FGFR4 signaling

RHO GTPases Activate WASPs and WAVEs

RAF/MAP kinase cascade

MAP2K and MAPK activation

Negative feedback regulation of MAPK pathway

Negative regulation of MAPK pathway

Signaling by moderate kinase activity BRAF mutants

Signaling by high-kinase activity BRAF mutants

Signaling by RAS mutants

Signaling by BRAF and RAF fusions

Paradoxical activation of RAF signaling by kinase inactive BRAF

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

RNA Polymerase I Promoter Opening

Signal attenuation

Advanced glycosylation endproduct receptor signaling

Gastrin-CREB signalling pathway via PKC and MAPK

ESR-mediated signaling

RUNX2 regulates osteoblast differentiation

Regulation of PTEN gene transcription

Growth hormone receptor signaling

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000100030	MAPK1 / P28482 / mitogen-activated protein kinase 1	/ reaction
ENSG00000075413	MARK3 / P27448 / microtubule affinity regulating kinase 3	/ complex / reaction
ENSG00000108861	DUSP3 / P51452 / dual specificity phosphatase 3	/ reaction
ENSG00000120875	DUSP4 / Q13115 / dual specificity phosphatase 4	/ reaction
ENSG00000112640	Q14738 / PPP2R5D / protein phosphatase 2 regulatory subunit Bdelta	/ reaction
ENSG00000132155	RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase	/ complex / reaction
ENSG00000137331	IER3 / P46695 / immediate early response 3	/ complex / reaction
ENSG00000068971	Q15173 / PPP2R5B / protein phosphatase 2 regulatory subunit Bbeta	/ complex / reaction
ENSG00000105722	ERF / P50548 / ETS2 repressor factor	/ reaction
ENSG00000109270	Q9UHA4 / LAMTOR3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	/ complex / reaction
ENSG00000126767	ELK1 / P19419 / ELK1, ETS transcription factor	/ reaction
ENSG00000118972	FGF23 / Q9GZV9 / fibroblast growth factor 23	/ reaction
ENSG00000134962	KLB / Q86Z14 / klotho beta	/ reaction
ENSG00000068078	FGFR3 / P22607 / fibroblast growth factor receptor 3	/ reaction
ENSG00000126934	MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2	/ complex / reaction
ENSG00000071242	Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2	/ reaction
ENSG00000102882	MAPK3 / P27361 / mitogen-activated protein kinase 3	/ complex / reaction
ENSG00000133703	KRAS / P01116 / KRAS proto-oncogene, GTPase	/ complex / reaction
ENSG00000108312	UBTF / P17480 / upstream binding transcription factor, RNA polymerase I	/ reaction
ENSG00000144730	IL17RD / Q8NFM7 / interleukin 17 receptor D	/ complex / reaction
ENSG00000170345	FOS / P01100 / Fos proto-oncogene, AP-1 transcription factor subunit	/ reaction
ENSG00000067955	CBFB / Q13951 / core-binding factor beta subunit	/ reaction
ENSG00000160867	FGFR4 / P22455 / fibroblast growth factor receptor 4	/ reaction
ENSG00000169047	IRS1 / P35568 / insulin receptor substrate 1	/ reaction
ENSG00000172216	CEBPB / P17676 / CCAAT/enhancer binding protein beta	/ reaction
ENSG00000174775	HRAS / P01112 / HRas proto-oncogene, GTPase	/ complex / reaction
ENSG00000141068	KSR1 / Q8IVT5 / kinase suppressor of ras 1	/ complex / reaction
ENSG00000169032	MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1	/ complex / reaction
ENSG00000162344	FGF19 / O95750 / fibroblast growth factor 19	/ reaction
ENSG00000157764	BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase	/ complex / reaction
ENSG00000141480	ARRB2 / P32121 / arrestin beta 2	/ complex / reaction
ENSG00000134954	ETS1 / P14921 / ETS proto-oncogene 1, transcription factor	/ reaction
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ reaction
ENSG00000077782	FGFR1 / P11362 / fibroblast growth factor receptor 1	/ reaction
ENSG00000181104	F2R / P25116 / coagulation factor II thrombin receptor	/ complex / reaction
ENSG00000066468	FGFR2 / P21802 / fibroblast growth factor receptor 2	/ reaction
ENSG00000078304	Q13362 / PPP2R5C / protein phosphatase 2 regulatory subunit Bgamma	/ complex / reaction
ENSG00000175866	BAIAP2 / Q9UQB8 / BAI1 associated protein 2	/ reaction
ENSG00000136238	RAC1 / P63000 / Rac family small GTPase 1	/ reaction
ENSG00000166913	YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta	/ complex / reaction
ENSG00000124813	RUNX2 / Q13950 / runt related transcription factor 2	/ reaction
ENSG00000157557	ETS2 / P15036 / ETS proto-oncogene 2, transcription factor	/ reaction
ENSG00000137486	ARRB1 / P49407 / arrestin beta 1	/ complex / reaction
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ complex / reaction
ENSG00000117676	Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1	/ reaction
ENSG00000204305	AGER / Q15109 / advanced glycosylation end-product specific receptor	/ complex / reaction
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ reaction
ENSG00000116586	Q9Y2Q5 / LAMTOR2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	/ complex / reaction
ENSG00000213281	NRAS / P01111 / NRAS proto-oncogene, GTPase	/ complex / reaction
ENSG00000185950	IRS2 / Q9Y4H2 / insulin receptor substrate 2	/ reaction
ENSG00000177189	P51812 / RPS6KA3 / ribosomal protein S6 kinase A3	/ reaction
ENSG00000133116	KL / klotho / Q9UEF7	/ reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ reaction
ENSG00000166225	FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2	/ reaction
ENSG00000185122	HSF1 / Q00613 / heat shock transcription factor 1	/ reaction
ENSG00000123154	WDR83 / Q9BRX9 / WD repeat domain 83	/ complex / reaction
ENSG00000100784	O75582 / RPS6KA5 / ribosomal protein S6 kinase A5	/ reaction
ENSG00000139318	DUSP6 / Q16828 / dual specificity phosphatase 6	/ reaction
ENSG00000130829	DUSP9 / Q99956 / dual specificity phosphatase 9	/ reaction
ENSG00000162734	PEA15 / Q15121 / proliferation and apoptosis adaptor protein 15	/ complex / reaction
ENSG00000138166	DUSP5 / Q16690 / dual specificity phosphatase 5	/ reaction
ENSG00000164086	DUSP7 / Q16829 / dual specificity phosphatase 7	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr