ENSG00000166225


Homo sapiens

Features
Gene ID: ENSG00000166225
  
Biological name :FRS2
  
Synonyms : fibroblast growth factor receptor substrate 2 / FRS2 / Q8WU20
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q15
Gene start: 69470349
Gene end: 69579789
  
Corresponding Affymetrix probe sets: 221308_at (Human Genome U133 Plus 2.0 Array)   226045_at (Human Genome U133 Plus 2.0 Array)   238486_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450000
Ensembl peptide - ENSP00000449432
Ensembl peptide - ENSP00000450048
Ensembl peptide - ENSP00000381083
Ensembl peptide - ENSP00000447007
Ensembl peptide - ENSP00000447241
Ensembl peptide - ENSP00000447724
Ensembl peptide - ENSP00000447804
Ensembl peptide - ENSP00000447978
Ensembl peptide - ENSP00000449105
Ensembl peptide - ENSP00000449111
NCBI entrez gene - 10818     See in Manteia.
OMIM - 607743
RefSeq - NM_001278351
RefSeq - XM_017018719
RefSeq - XM_017018718
RefSeq - XM_017018717
RefSeq - NM_006654
RefSeq - NM_001278357
RefSeq - NM_001278356
RefSeq - NM_001278355
RefSeq - NM_001278354
RefSeq - NM_001042555
RefSeq - NM_001278353
RefSeq Peptide - NP_001265286
RefSeq Peptide - NP_001036020
RefSeq Peptide - NP_001265280
RefSeq Peptide - NP_001265282
RefSeq Peptide - NP_001265283
RefSeq Peptide - NP_001265284
RefSeq Peptide - NP_001265285
RefSeq Peptide - NP_006645
swissprot - A0A0G2JL00
swissprot - Q8WU20
swissprot - F8VS98
swissprot - L7RTG7
swissprot - F8VZI4
swissprot - F8VZ12
swissprot - F8VYZ7
swissprot - F8VX65
swissprot - F8VP54
swissprot - F8VW66
Ensembl - ENSG00000166225
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frs2aENSDARG00000045873Danio rerio
 frs2bENSDARG00000037353Danio rerio
 FRS2ENSGALG00000009966Gallus gallus
 Frs2ENSMUSG00000020170Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FRS3 / O43559 / fibroblast growth factor receptor substrate 3ENSG0000013721848


Protein motifs (from Interpro)
Interpro ID Name
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000186 activation of MAPKK activity TAS
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001702 gastrulation with mouth forming second IEA
 biological_processGO:0001759 organ induction IEA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007405 neuroblast proliferation IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0008595 anterior/posterior axis specification, embryo IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0046619 optic placode formation involved in camera-type eye formation IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0050678 regulation of epithelial cell proliferation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
 biological_processGO:0070307 lens fiber cell development IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:2000726 negative regulation of cardiac muscle cell differentiation IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane TAS
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IPI
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0019211 phosphatase activator activity TAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
Frs2-mediated activation
Constitutive Signaling by Aberrant PI3K in Cancer
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
Activated NTRK2 signals through FRS2 and FRS3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex
 ENSG00000125650 PSPN / O60542 / persephin  / complex / reaction
 ENSG00000118972 FGF23 / Q9GZV9 / fibroblast growth factor 23  / complex / reaction
 ENSG00000134962 KLB / Q86Z14 / klotho beta  / complex / reaction
 ENSG00000068078 FGFR3 / P22607 / fibroblast growth factor receptor 3  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / complex / reaction
 ENSG00000147475 ERLIN2 / O94905 / ER lipid raft associated 2  / complex / reaction
 ENSG00000160867 FGFR4 / P22455 / fibroblast growth factor receptor 4  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex / reaction
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / complex / reaction
 ENSG00000162344 FGF19 / O95750 / fibroblast growth factor 19  / complex / reaction
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / complex / reaction
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / complex / reaction
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / complex / reaction
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / complex / reaction
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / complex / reaction
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / complex / reaction
 ENSG00000133116 KL / klotho / Q9UEF7  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex / reaction
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000225950 NTF4 / P34130 / neurotrophin 4  / complex / reaction






 

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