ENSMUSG00000020170


Mus musculus

Features
Gene ID: ENSMUSG00000020170
  
Biological name :Frs2
  
Synonyms : Fibroblast growth factor receptor substrate 2 / Frs2 / Q8C180
  
Possible biological names infered from orthology : Q8WU20
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 117069427
Gene end: 117148534
  
Corresponding Affymetrix probe sets: 10372618 (MoGene1.0st)   1437891_at (Mouse Genome 430 2.0 Array)   1444162_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020381
NCBI entrez gene - 327826     See in Manteia.
MGI - MGI:1100860
RefSeq - NM_177798
RefSeq Peptide - NP_808466
swissprot - Q8C180
Ensembl - ENSMUSG00000020170
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frs2aENSDARG00000045873Danio rerio
 frs2bENSDARG00000037353Danio rerio
 FRS2ENSGALG00000009966Gallus gallus
 FRS2ENSG00000166225Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Frs3 / Q91WJ0 / Fibroblast growth factor receptor substrate 3 / O43559*ENSMUSG0000002326648


Protein motifs (from Interpro)
Interpro ID Name
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0001759 organ induction IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA
 biological_processGO:0007405 neuroblast proliferation IMP
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0008595 anterior/posterior axis specification, embryo IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0046619 optic placode formation involved in camera-type eye formation IMP
 biological_processGO:0050678 regulation of epithelial cell proliferation IMP
 biological_processGO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
 biological_processGO:0070307 lens fiber cell development IMP
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:2000726 negative regulation of cardiac muscle cell differentiation IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IDA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
Frs2-mediated activation
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Activated NTRK2 signals through FRS2 and FRS3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Dmc1tm1Jcs/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000785 telencephalon hypoplasia "reduced cell number in cerebral cortex and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000856 abnormal cerebellar plate morphology "malformed embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium" [J:45302]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

 MP:0004276 abnormal medial ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Frs2tm1Schl/Frs2tm1Schl
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Dmc1tm1Jcs/Dmc1Mei11
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
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Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0030250 frontonasal prominence hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [MGI:anna]
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Allelic Composition: Foxg1tm1(cre)Skm/Foxg1+,Frs2tm1Fwan/Frs2tm1Fwan,Frs3tm1Jheb/Frs3tm1Jheb
Genetic Background: involves: 129 * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / complex / reaction
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000002664 Pspn / persephin / O60542*  / complex / reaction
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex / reaction
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex / reaction
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex / reaction
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / complex / reaction
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex / reaction
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex / reaction
 ENSMUSG00000074121 Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*  / complex / reaction
 ENSMUSG00000048482 Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*  / complex / reaction
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / complex / reaction
 ENSMUSG00000055254 Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / complex / reaction
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction






 

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