ENSG00000167193


Homo sapiens
regulationCRKbindingshresponseproteindomainsignalinggrowthfactorreceptorcellpathwaycellularsignaltransductionactivityactinstimulusmembranecrksuperfamilyactivationcytoskeletonracgtpaseephrincomplexinsulin-likemetn-terminal

Features
Gene ID: ENSG00000167193
  
Biological name :CRK
  
Synonyms : CRK / CRK proto-oncogene, adaptor protein / P46108
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.3
Gene start: 1420689
Gene end: 1463162
  
Corresponding Affymetrix probe sets: 202224_at (Human Genome U133 Plus 2.0 Array)   202225_at (Human Genome U133 Plus 2.0 Array)   202226_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000381942
Ensembl peptide - ENSP00000300574
Ensembl peptide - ENSP00000459505
NCBI entrez gene - 1398     See in Manteia.
OMIM - 164762
RefSeq - NM_005206
RefSeq - NM_016823
RefSeq Peptide - NP_058431
RefSeq Peptide - NP_005197
swissprot - P46108
swissprot - A0A0S2Z3K9
swissprot - A0A0S2Z3Q4
swissprot - I3L297
swissprot - L7RT18
Ensembl - ENSG00000167193
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crkENSDARG00000055635Danio rerio
 CRKENSGALG00000002656Gallus gallus
 CrkENSMUSG00000017776Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CRKL / P46109 / CRK like proto-oncogene, adaptor proteinENSG0000009994259


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR035457  CRK, N-terminal SH3 domain
 IPR035458  CRK, C-terminal SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusresponse to external stimulusresponse to biotic stimulusbiosynthetic processcellular component organizationregulation of biological qualityanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentresponse to chemicalactin filament-based processimmune responseestablishment of localizationimmune effector processresponse to stressleukocyte mediated cytotoxicityresponse to endogenous stimuluscellular component biogenesiscell adhesionnitronitrogen compound metabolic processcell cell communicationcellucellular metabolic processprimaprimary metabolic processregulregulation of molecular functionorganorganic substance metabolic processcellucellular response to stimulusresporesponse to external stimulusresporesponse to biotic stimulusbiosybiosynthetic processcellucellular component organizationregulregulation of biological qualityanatoanatomical structure developmentcellucellular developmental processlocallocalization of cellmovemmovement of cell or subcellular componentresporesponse to chemicalactinactin filament-based processimmunimmune responseestabestablishment of localizationimmunimmune effector processresporesponse to stressleukoleukocyte mediated cytotoxicityresporesponse to endogenous stimuluscellucellular component biogenesiscell cell adhesion
protein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingprotein bindingmolecular adaptor activitymolecular adaptor activity
cellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity TAS
 biological_processGO:0001878 response to yeast IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0009966 regulation of signal transduction IDA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032956 regulation of actin cytoskeleton organization IDA
 biological_processGO:0035020 regulation of Rac protein signal transduction IEA
 biological_processGO:0035728 response to hepatocyte growth factor IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043393 regulation of protein binding IMP
 biological_processGO:0045953 negative regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0061045 negative regulation of wound healing IMP
 biological_processGO:0061847 response to cholecystokinin IEA
 biological_processGO:0071538 SH2 domain-mediated complex assembly IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1901652 response to peptide IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 biological_processGO:1990859 cellular response to endothelin IEA
 biological_processGO:2000146 negative regulation of cell motility IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IPI
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IDA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0042169 SH2 domain binding IPI
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0045309 protein phosphorylated amino acid binding IDA
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0097110 scaffold protein binding IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000089159 PXN / P49023 / paxillin  / complex / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / complex / reaction
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / complex / reaction
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / complex / reaction
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000134313 Q9ULH0 / KIDINS220 / kinase D interacting substrate 220  / complex
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / complex / reaction
 ENSG00000165527 ARF6 / P62330 / ADP ribosylation factor 6  / complex
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / complex / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction / complex
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000125447 GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3  / complex
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / complex / reaction
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / complex / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex / reaction
 ENSG00000143226 FCGR2A / P12318 / Fc fragment of IgG receptor IIa  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000137076 TLN1 / Q9Y490 / talin 1  / complex / reaction
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / complex / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / complex / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000077420 Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000203747 FCGR3A / P08637 / Fc fragment of IgG receptor IIIa  / complex / reaction
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex / reaction
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex / reaction
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / complex / reaction
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / complex / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / complex / reaction






 

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