ENSG00000150760


Homo sapiens

Features
Gene ID: ENSG00000150760
  
Biological name :DOCK1
  
Synonyms : dedicator of cytokinesis 1 / DOCK1 / Q14185
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q26.2
Gene start: 126905409
Gene end: 127452517
  
Corresponding Affymetrix probe sets: 203187_at (Human Genome U133 Plus 2.0 Array)   232930_at (Human Genome U133 Plus 2.0 Array)   232973_at (Human Genome U133 Plus 2.0 Array)   241708_at (Human Genome U133 Plus 2.0 Array)   241709_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000485033
Ensembl peptide - ENSP00000280333
NCBI entrez gene - 1793     See in Manteia.
OMIM - 601403
RefSeq - XM_017015816
RefSeq - NM_001290223
RefSeq - NM_001380
RefSeq - XM_011539422
RefSeq - XM_011539424
RefSeq - XM_017015813
RefSeq Peptide - NP_001277152
RefSeq Peptide - NP_001371
swissprot - A0A096LNH6
swissprot - Q14185
Ensembl - ENSG00000150760
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock1ENSDARG00000099093Danio rerio
 DOCK1ENSGALG00000042259Gallus gallus
 Dock1ENSMUSG00000058325Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOCK5 / Q9H7D0 / dedicator of cytokinesis 5ENSG0000014745965
DOCK2 / Q92608 / dedicator of cytokinesis 2ENSG0000013451658
DOCK3 / Q8IZD9 / dedicator of cytokinesis 3ENSG0000008853837
DOCK4 / Q8N1I0 / dedicator of cytokinesis 4ENSG0000012851237


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR030717  Dedicator of cytokinesis protein 1
 IPR032376  Dedicator of cytokinesis, N-terminal domain
 IPR035892  C2 domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006911 phagocytosis, engulfment TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007229 integrin-mediated signaling pathway TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / complex / reaction
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000089159 PXN / P49023 / paxillin  / complex / reaction
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / complex / reaction
 ENSG00000173210 ABLIM3 / O94929 / actin binding LIM protein family member 3  / complex / reaction
 ENSG00000099204 ABLIM1 / O14639 / actin binding LIM protein 1  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000163995 ABLIM2 / Q6H8Q1 / actin binding LIM protein family member 2  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex / reaction
 ENSG00000143226 FCGR2A / P12318 / Fc fragment of IgG receptor IIa  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000203747 FCGR3A / P08637 / Fc fragment of IgG receptor IIIa  / complex / reaction
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex / reaction
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex / reaction
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / complex / reaction
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / complex / reaction






 

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