ENSG00000106299


Homo sapiens

Features
Gene ID: ENSG00000106299
  
Biological name :WASL
  
Synonyms : O00401 / WASL / Wiskott-Aldrich syndrome like
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q31.32
Gene start: 123681935
Gene end: 123749067
  
Corresponding Affymetrix probe sets: 205809_s_at (Human Genome U133 Plus 2.0 Array)   205810_s_at (Human Genome U133 Plus 2.0 Array)   224813_at (Human Genome U133 Plus 2.0 Array)   230340_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000223023
NCBI entrez gene - 8976     See in Manteia.
OMIM - 605056
RefSeq - NM_003941
RefSeq Peptide - NP_003932
swissprot - O00401
Ensembl - ENSG00000106299
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 waslaENSDARG00000014113Danio rerio
 waslbENSDARG00000006283Danio rerio
 ENSGALG00000037819Gallus gallus
 WASLENSGALG00000008797Gallus gallus
 WaslENSMUSG00000029684Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WAS / P42768 / Wiskott-Aldrich syndromeENSG0000001528548


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000697  WH1/EVH1 domain
 IPR003124  WH2 domain
 IPR011026  Wiscott-Aldrich syndrome protein, C-terminal
 IPR011993  PH-like domain superfamily
 IPR030214  Neural Wiskott-Aldrich syndrome protein
 IPR033927  WASP family, EVH1 domain
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006900 vesicle budding from membrane ISS
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008154 actin polymerization or depolymerization TAS
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0016050 vesicle organization ISS
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030050 vesicle transport along actin filament ISS
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0034629 cellular protein-containing complex localization IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0050999 regulation of nitric-oxide synthase activity TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051491 positive regulation of filopodium assembly ISS
 biological_processGO:0051653 spindle localization IEA
 biological_processGO:0060997 dendritic spine morphogenesis IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:1903526 negative regulation of membrane tubulation IDA
 biological_processGO:2000370 positive regulation of clathrin-dependent endocytosis ISS
 biological_processGO:2000402 negative regulation of lymphocyte migration IMP
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030478 actin cap IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030695 GTPase regulator activity TAS


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
NOSTRIN mediated eNOS trafficking
Nephrin family interactions
EPHB-mediated forward signaling
DCC mediated attractive signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / reaction / complex
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / reaction / complex
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000038382 TRIO / O75962 / trio Rho guanine nucleotide exchange factor  / complex / reaction
 ENSG00000105974 CAV1 / Q03135 / caveolin 1  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000075624 ACTB / P60709 / actin beta  / complex / reaction
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction
 ENSG00000161270 NPHS1 / O60500 / NPHS1, nephrin  / complex / reaction
 ENSG00000183853 Q96J84 / KIRREL1 / kirre like nephrin family adhesion molecule 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000122574 WIPF3 / A6NGB9 / WAS/WASL interacting protein family member 3  / reaction
 ENSG00000164867 NOS3 / P29474 / nitric oxide synthase 3  / reaction
 ENSG00000213672 Q9NZQ3 / NCKIPSD / NCK interacting protein with SH3 domain  / reaction
 ENSG00000115935 WIPF1 / O43516 / WAS/WASL interacting protein family member 1  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction
 ENSG00000163072 Q8IVI9 / NOSTRIN / nitric oxide synthase trafficking  / complex / reaction
 ENSG00000171475 WIPF2 / Q8TF74 / WAS/WASL interacting protein family member 2  / reaction
 ENSG00000205726 ITSN1 / Q15811 / intersectin 1  / complex / reaction






 

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