ENSG00000125266


Homo sapiens

Features
Gene ID: ENSG00000125266
  
Biological name :EFNB2
  
Synonyms : EFNB2 / ephrin B2 / P52799
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q33.3
Gene start: 106489731
Gene end: 106535662
  
Corresponding Affymetrix probe sets: 202668_at (Human Genome U133 Plus 2.0 Array)   202669_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000245323
Ensembl peptide - ENSP00000493716
NCBI entrez gene - 1948     See in Manteia.
OMIM - 600527
RefSeq - XM_017020406
RefSeq - NM_004093
RefSeq Peptide - NP_004084
swissprot - P52799
Ensembl - ENSG00000125266
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efnb2aENSDARG00000020164Danio rerio
 efnb2bENSDARG00000074050Danio rerio
 EFNB2ENSGALG00000029175Gallus gallus
 Efnb2ENSMUSG00000001300Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EFNB1 / P98172 / ephrin B1ENSG0000009077654
EFNB3 / Q15768 / ephrin B3ENSG0000010894741


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034255  Ephrin-B ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IDA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IMP
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 biological_processGO:0050920 regulation of chemotaxis IDA
 biological_processGO:0072178 nephric duct morphogenesis IMP
 biological_processGO:1901216 positive regulation of neuron death IDA
 biological_processGO:1903849 positive regulation of aorta morphogenesis IMP
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / complex / reaction
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / - / complex / reaction
 ENSG00000108262 GIT1 / Q9Y2X7 / GIT ArfGAP 1  / complex / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / - / complex / reaction
 ENSG00000102606 Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / - / complex / reaction
 ENSG00000160145 KALRN / O60229 / kalirin RhoGEF kinase  / complex / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / complex / reaction
 ENSG00000137575 SDCBP / O00560 / syndecan binding protein  / complex / reaction
 ENSG00000156299 TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000169439 SDC2 / P34741 / syndecan 2  / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000075624 ACTB / P60709 / actin beta  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000214944 Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / complex / reaction
 ENSG00000145715 RASA1 / P20936 / RAS p21 protein activator 1  / complex / reaction
 ENSG00000176105 YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000205726 ITSN1 / Q15811 / intersectin 1  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr