Manteia

ENSG00000165025

Homo sapiens

Features

Gene ID:	ENSG00000165025

Biological name :	SYK

Synonyms :	P43405 / spleen associated tyrosine kinase / SYK

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	9
Strand:	1
Band:	q22.2
Gene start:	90801787
Gene end:	90898549

Corresponding Affymetrix probe sets:	207540_s_at (Human Genome U133 Plus 2.0 Array) 209269_s_at (Human Genome U133 Plus 2.0 Array) 226068_at (Human Genome U133 Plus 2.0 Array) 244023_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000364904 Ensembl peptide - ENSP00000364907 Ensembl peptide - ENSP00000364898 Ensembl peptide - ENSP00000364899 NCBI entrez gene - 6850 See in Manteia. OMIM - 600085 RefSeq - XM_011518946 RefSeq - NM_001135052 RefSeq - NM_001174167 RefSeq - NM_001174168 RefSeq - NM_003177 RefSeq - XM_005252147 RefSeq Peptide - NP_001167639 RefSeq Peptide - NP_001167638 RefSeq Peptide - NP_001128524 RefSeq Peptide - NP_003168 swissprot - A0A024R244 swissprot - A0A024R273 swissprot - P43405 Ensembl - ENSG00000165025

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
syk	ENSDARG00000008186	Danio rerio
SYK	ENSGALG00000015216	Gallus gallus
Syk	ENSMUSG00000021457	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70	ENSG00000115085	53
ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4	ENSG00000178568	26
EGFR / P00533 / epidermal growth factor receptor	ENSG00000146648	25
ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3	ENSG00000065361	24
ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2	ENSG00000141736	24
PTK2 / Q05397 / protein tyrosine kinase 2	ENSG00000169398	22
TNK2 / Q07912 / tyrosine kinase non receptor 2	ENSG00000061938	20
PTK2B / Q14289 / protein tyrosine kinase 2 beta	ENSG00000120899	20
TNK1 / Q13470 / tyrosine kinase non receptor 1	ENSG00000174292	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR000980	SH2 domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR012234	Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR023420	Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily
IPR035838	SYK/ZAP-70, N-terminal SH2 domain
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000187	activation of MAPK activity	IEA
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0001820	serotonin secretion	IEA
biological_process	GO:0001945	lymph vessel development	ISS
biological_process	GO:0002092	positive regulation of receptor internalization	IEA
biological_process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
biological_process	GO:0002250	adaptive immune response	IBA
biological_process	GO:0002281	macrophage activation involved in immune response	IBA
biological_process	GO:0002283	neutrophil activation involved in immune response	IBA
biological_process	GO:0002366	leukocyte activation involved in immune response	ISS
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0002554	serotonin secretion by platelet	ISS
biological_process	GO:0006468	protein phosphorylation	IDA
biological_process	GO:0006954	inflammatory response	IBA
biological_process	GO:0007159	leukocyte cell-cell adhesion	IDA
biological_process	GO:0007166	cell surface receptor signaling pathway	IEA
biological_process	GO:0007167	enzyme linked receptor protein signaling pathway	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA
biological_process	GO:0007229	integrin-mediated signaling pathway	NAS
biological_process	GO:0007257	activation of JUN kinase activity	IEA
biological_process	GO:0008283	cell proliferation	TAS
biological_process	GO:0009887	animal organ morphogenesis	TAS
biological_process	GO:0010543	regulation of platelet activation	ISS
biological_process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	IMP
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018105	peptidyl-serine phosphorylation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0019370	leukotriene biosynthetic process	IEA
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0030593	neutrophil chemotaxis	IDA
biological_process	GO:0031623	receptor internalization	ISS
biological_process	GO:0032481	positive regulation of type I interferon production	IEA
biological_process	GO:0032928	regulation of superoxide anion generation	ISS
biological_process	GO:0033630	positive regulation of cell adhesion mediated by integrin	IBA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	IEA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	IBA
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0038110	interleukin-2-mediated signaling pathway	TAS
biological_process	GO:0042742	defense response to bacterium	ISS
biological_process	GO:0042991	obsolete transcription factor import into nucleus	IMP
biological_process	GO:0043306	positive regulation of mast cell degranulation	IBA
biological_process	GO:0043313	regulation of neutrophil degranulation	ISS
biological_process	GO:0043366	beta selection	IEA
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0045401	positive regulation of interleukin-3 biosynthetic process	IEA
biological_process	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	IEA
biological_process	GO:0045579	positive regulation of B cell differentiation	IMP
biological_process	GO:0045588	positive regulation of gamma-delta T cell differentiation	IEA
biological_process	GO:0045780	positive regulation of bone resorption	ISS
biological_process	GO:0046638	positive regulation of alpha-beta T cell differentiation	IEA
biological_process	GO:0046641	positive regulation of alpha-beta T cell proliferation	IBA
biological_process	GO:0046777	protein autophosphorylation	IEA
biological_process	GO:0048514	blood vessel morphogenesis	ISS
biological_process	GO:0050715	positive regulation of cytokine secretion	IEA
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0050764	regulation of phagocytosis	ISS
biological_process	GO:0050850	positive regulation of calcium-mediated signaling	IEA
biological_process	GO:0050853	B cell receptor signaling pathway	ISS
biological_process	GO:0051090	regulation of DNA-binding transcription factor activity	IMP
biological_process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISS
biological_process	GO:0071226	cellular response to molecule of fungal origin	ISS
biological_process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	ISS
biological_process	GO:0090237	regulation of arachidonic acid secretion	ISS
biological_process	GO:0090330	regulation of platelet aggregation	IBA
biological_process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	IEA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0019815	B cell receptor complex	IEA
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA
cellular_component	GO:0032009	early phagosome	ISS
cellular_component	GO:0032991	protein-containing complex	IDA
cellular_component	GO:0042101	T cell receptor complex	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0001784	phosphotyrosine residue binding	IPI
molecular_function	GO:0004672	protein kinase activity	IDA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IDA
molecular_function	GO:0004713	protein tyrosine kinase activity	NAS
molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TAS
molecular_function	GO:0004716	obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity	IEA
molecular_function	GO:0005178	integrin binding	IPI
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0019902	phosphatase binding	IEA
molecular_function	GO:0035325	Toll-like receptor binding	IEA
molecular_function	GO:0042169	SH2 domain binding	IEA

Pathways (from Reactome)

Pathway description

GPVI-mediated activation cascade

FCGR activation

Regulation of actin dynamics for phagocytic cup formation

Role of phospholipids in phagocytosis

DAP12 signaling

Fc epsilon receptor (FCERI) signaling

Role of LAT2/NTAL/LAB on calcium mobilization

FCERI mediated MAPK activation

FCERI mediated Ca+2 mobilization

Integrin alphaIIb beta3 signaling

CLEC7A (Dectin-1) signaling

Dectin-2 family

Interleukin-2 signaling

Regulation of signaling by CBL

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000100385	IL2RB / P14784 / interleukin 2 receptor subunit beta	/ complex / reaction
ENSG00000109471	IL2 / P60568 / interleukin 2	/ complex / reaction
ENSG00000010810	FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000105647	O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2	/ complex / reaction
ENSG00000095585	BLNK / Q8WV28 / B cell linker	/ complex / reaction
ENSG00000213809	KLRK1 / P26718 / killer cell lectin like receptor K1	/ complex / reaction
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ complex / reaction
ENSG00000134460	IL2RA / P01589 / interleukin 2 receptor subunit alpha	/ complex / reaction
ENSG00000011600	O43914 / TYROBP / TYRO protein tyrosine kinase binding protein	/ complex / reaction
ENSG00000172243	CLEC7A / Q9BXN2 / C-type lectin domain containing 7A	/ complex / reaction
ENSG00000162493	PDPN / Q86YL7 / podoplanin	/ complex / reaction
ENSG00000166523	CLEC4E / Q9ULY5 / C-type lectin domain family 4 member E	/ complex / reaction
ENSG00000158869	FCER1G / P30273 / Fc fragment of IgE receptor Ig	/ complex / reaction
ENSG00000088053	GP6 / Q9HCN6 / glycoprotein VI platelet	/ complex / reaction
ENSG00000165682	CLEC1B / Q9P126 / C-type lectin domain family 1 member B	/ complex / reaction
ENSG00000147168	IL2RG / P31785 / interleukin 2 receptor subunit gamma	/ complex / reaction
ENSG00000149534	MS4A2 / Q01362 / membrane spanning 4-domains A2	/ complex / reaction
ENSG00000051382	P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	/ complex / reaction
ENSG00000141968	VAV1 / P15498 / vav guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000160654	CD3G / P09693 / CD3g molecule	/ complex / reaction
ENSG00000143226	FCGR2A / P12318 / Fc fragment of IgG receptor IIa	/ complex / reaction
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ complex / reaction
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ complex / reaction
ENSG00000162434	JAK1 / P23458 / Janus kinase 1	/ complex / reaction
ENSG00000182866	LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000095970	TREM2 / Q9NZC2 / triggering receptor expressed on myeloid cells 2	/ complex / reaction
ENSG00000134539	KLRD1 / Q13241 / killer cell lectin like receptor D1	/ complex / reaction
ENSG00000198821	CD247 / P20963 / CD247 molecule	/ complex / reaction
ENSG00000166710	B2M / P61769 / beta-2-microglobulin	/ complex / reaction
ENSG00000203747	FCGR3A / P08637 / Fc fragment of IgG receptor IIIa	/ complex / reaction
ENSG00000150337	FCGR1A / P12314 / Fc fragment of IgG receptor Ia	/ complex / reaction
ENSG00000179639	FCER1A / P12319 / Fc fragment of IgE receptor Ia	/ complex / reaction
ENSG00000160293	VAV2 / P52735 / vav guanine nucleotide exchange factor 2	/ complex / reaction
ENSG00000211891	IGHE / P01854 / immunoglobulin heavy constant epsilon	/ complex / reaction
ENSG00000007312	CD79B / P40259 / CD79b molecule	/ complex / reaction
ENSG00000043462	LCP2 / Q13094 / lymphocyte cytosolic protein 2	/ reaction
ENSG00000105369	CD79A / P11912 / CD79a molecule	/ complex / reaction
ENSG00000124181	PLCG1 / P19174 / phospholipase C gamma 1	/ complex / reaction
ENSG00000127314	RAP1B / P61224 / RAP1B, member of RAS oncogene family	/ complex / reaction
ENSG00000110799	VWF / P04275 / von Willebrand factor	/ complex / reaction
ENSG00000005961	ITGA2B / P08514 / integrin subunit alpha 2b	/ complex / reaction
ENSG00000062598	ELMO2 / Q96JJ3 / engulfment and cell motility 2	/ complex / reaction
ENSG00000167193	CRK / P46108 / CRK proto-oncogene, adaptor protein	/ complex / reaction
ENSG00000171560	FGA / P02671 / fibrinogen alpha chain	/ complex / reaction
ENSG00000150760	DOCK1 / Q14185 / dedicator of cytokinesis 1	/ complex / reaction
ENSG00000171564	FGB / P02675 / fibrinogen beta chain	/ complex / reaction
ENSG00000155849	ELMO1 / Q92556 / engulfment and cell motility 1	/ complex / reaction
ENSG00000086730	LAT2 / Q9GZY6 / linker for activation of T cells family member 2	/ reaction
ENSG00000010671	BTK / Q06187 / Bruton tyrosine kinase	/ reaction
ENSG00000115414	FN1 / P02751 / fibronectin 1	/ complex / reaction
ENSG00000100351	GRAP2 / O75791 / GRB2-related adaptor protein 2	/ reaction
ENSG00000137076	TLN1 / Q9Y490 / talin 1	/ complex / reaction
ENSG00000033327	GAB2 / Q9UQC2 / GRB2 associated binding protein 2	/ reaction
ENSG00000134215	VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3	/ complex / reaction
ENSG00000171557	FGG / P02679 / fibrinogen gamma chain	/ complex / reaction
ENSG00000116473	RAP1A / P62834 / RAP1A, member of RAS oncogene family	/ complex / reaction
ENSG00000077420	Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein	/ complex / reaction
ENSG00000213658	LAT / O43561 / linker for activation of T cells	/ reaction
ENSG00000197943	PLCG2 / P16885 / phospholipase C gamma 2	/ complex / reaction
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ complex / reaction
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ reaction
ENSG00000211898	IGHD / P01880 / immunoglobulin heavy constant delta	/ complex / reaction
ENSG00000165025	SYK / P43405 / spleen associated tyrosine kinase	/ complex / reaction
ENSG00000211893	IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)	/ reaction / complex
ENSG00000211896	IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)	/ reaction / complex
ENSG00000211892	IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)	/ reaction / complex
ENSG00000205809	KLRC2 / P26717 / killer cell lectin like receptor C2	/ complex / reaction
ENSG00000211899	IGHM / P01871 / immunoglobulin heavy constant mu	/ complex / reaction
ENSG00000135605	TEC / P42680 / tec protein tyrosine kinase	/ reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ reaction / complex
ENSG00000113263	ITK / Q08881 / IL2 inducible T cell kinase	/ reaction
ENSG00000259207	ITGB3 / P05106 / integrin subunit beta 3	/ complex / reaction
ENSG00000147010	Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1	/ complex / reaction
ENSG00000205846	CLEC6A / Q6EIG7 / C-type lectin domain containing 6A	/ complex / reaction
ENSG00000254087	LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000105639	JAK3 / P52333 / Janus kinase 3	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr