ENSG00000147010


Homo sapiens

Features
Gene ID: ENSG00000147010
  
Biological name :SH3KBP1
  
Synonyms : Q96B97 / SH3 domain containing kinase binding protein 1 / SH3KBP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p22.12
Gene start: 19533975
Gene end: 19887601
  
Corresponding Affymetrix probe sets: 1553588_at (Human Genome U133 Plus 2.0 Array)   1554168_a_at (Human Genome U133 Plus 2.0 Array)   223082_at (Human Genome U133 Plus 2.0 Array)   235692_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409292
Ensembl peptide - ENSP00000369019
Ensembl peptide - ENSP00000369020
Ensembl peptide - ENSP00000380921
Ensembl peptide - ENSP00000388766
Ensembl peptide - ENSP00000369039
Ensembl peptide - ENSP00000369049
NCBI entrez gene - 30011     See in Manteia.
OMIM - 300374
RefSeq - XM_017029470
RefSeq - NM_001024666
RefSeq - NM_001184960
RefSeq - NM_031892
RefSeq - XM_017029461
RefSeq - XM_017029462
RefSeq - XM_017029463
RefSeq - XM_017029464
RefSeq - XM_017029465
RefSeq - XM_017029466
RefSeq - XM_017029467
RefSeq - XM_017029468
RefSeq - XM_017029469
RefSeq - XM_005274494
RefSeq - XM_011545498
RefSeq - XM_011545499
RefSeq - XM_011545500
RefSeq - XM_011545502
RefSeq - XM_011545503
RefSeq - XM_017029459
RefSeq - XM_017029460
RefSeq Peptide - NP_001171889
RefSeq Peptide - NP_114098
RefSeq Peptide - NP_001019837
swissprot - Q5JPT2
swissprot - Q5JPT3
swissprot - Q5JPT6
swissprot - Q5VSN0
swissprot - Q96B97
swissprot - Q5JPT1
Ensembl - ENSG00000147010
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh3kbp1ENSDARG00000075853Danio rerio
 SH3KBP1ENSGALG00000016420Gallus gallus
 Q8R550ENSMUSG00000040990Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CD2AP / Q9Y5K6 / CD2 associated proteinENSG0000019808736
A4FU49 / SH3D21 / SH3 domain containing 21ENSG0000021419317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR035770  SH3 domain-containing kinase-binding protein 1, first SH3 domain
 IPR035771  SH3 domain-containing kinase-binding protein 1, second SH3 domain
 IPR035772  SH3 domain-containing kinase-binding protein 1, third SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007267 cell-cell signaling NAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030139 endocytic vesicle ISS
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Reelin signalling pathway
InlB-mediated entry of Listeria monocytogenes into host cell
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000095585 BLNK / Q8WV28 / B cell linker  / complex
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000173406 DAB1 / O75553 / DAB1, reelin adaptor protein  / complex / reaction
 ENSG00000189056 RELN / P78509 / reelin  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000007312 CD79B / P40259 / CD79b molecule  / complex / reaction
 ENSG00000105369 CD79A / P11912 / CD79a molecule  / complex / reaction
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / complex / reaction
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / complex / reaction
 ENSG00000085832 EPS15 / P42566 / epidermal growth factor receptor pathway substrate 15  / complex / reaction
 ENSG00000211898 IGHD / P01880 / immunoglobulin heavy constant delta  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000147010 Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1  / complex
 ENSG00000147852 VLDLR / P98155 / very low density lipoprotein receptor  / complex / reaction
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / complex / reaction
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex
 ENSG00000211899 IGHM / P01871 / immunoglobulin heavy constant mu  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr