ENSG00000107295


Homo sapiens

Features
Gene ID: ENSG00000107295
  
Biological name :SH3GL2
  
Synonyms : Q99962 / SH3 domain containing GRB2 like 2, endophilin A1 / SH3GL2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p22.2
Gene start: 17579082
Gene end: 17797129
  
Corresponding Affymetrix probe sets: 205751_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369981
NCBI entrez gene - 6456     See in Manteia.
OMIM - 604465
RefSeq - NM_003026
RefSeq - XM_011518005
RefSeq Peptide - NP_003017
swissprot - Q99962
Ensembl - ENSG00000107295
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SH3GL2 (1 of many)ENSDARG00000039901Danio rerio
 sh3gl2aENSDARG00000023600Danio rerio
 Q8AXV1ENSGALG00000015096Gallus gallus
 Q62420ENSMUSG00000028488Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99961 / SH3GL1 / SH3 domain containing GRB2 like 1, endophilin A2ENSG0000014198573
Q99963 / SH3GL3 / SH3 domain containing GRB2 like 3, endophilin A3ENSG0000014060066
Q9Y371 / SH3GLB1 / SH3 domain containing GRB2 like, endophilin B1ENSG0000009703326
Q9NR46 / SH3GLB2 / SH3 domain containing GRB2 like, endophilin B2ENSG0000014834125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR004148  BAR domain
 IPR027267  AH/BAR domain superfamily
 IPR028501  Endophilin-A
 IPR035824  Endophilin-A, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002090 regulation of receptor internalization IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0016191 synaptic vesicle uncoating IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0048488 synaptic vesicle endocytosis IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0097484 dendrite extension IEA
 biological_processGO:0097749 membrane tubulation IEA
 biological_processGO:0097753 membrane bending IEA
 biological_processGO:0099050 vesicle scission IEA
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
EGFR downregulation
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Recycling pathway of L1
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / complex
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / complex / reaction
 ENSG00000100246 DNAL4 / O96015 / dynein axonemal light chain 4  / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / complex / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex / reaction
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex
 ENSG00000090889 KIF4A / O95239 / kinesin family member 4A  / complex / reaction
 ENSG00000147010 Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1  / complex
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / complex / reaction
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / complex / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000085832 EPS15 / P42566 / epidermal growth factor receptor pathway substrate 15  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / complex / reaction
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex
 ENSG00000226650 KIF4B / Q2VIQ3 / kinesin family member 4B  / complex / reaction






 

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