ENSG00000122705


Homo sapiens

Features
Gene ID: ENSG00000122705
  
Biological name :CLTA
  
Synonyms : clathrin light chain A / CLTA / P09496
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p13.3
Gene start: 36190856
Gene end: 36304781
  
Corresponding Affymetrix probe sets: 1560433_at (Human Genome U133 Plus 2.0 Array)   1560434_x_at (Human Genome U133 Plus 2.0 Array)   200960_x_at (Human Genome U133 Plus 2.0 Array)   204050_s_at (Human Genome U133 Plus 2.0 Array)   216293_at (Human Genome U133 Plus 2.0 Array)   216295_s_at (Human Genome U133 Plus 2.0 Array)   216296_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442869
Ensembl peptide - ENSP00000437508
Ensembl peptide - ENSP00000474266
Ensembl peptide - ENSP00000242284
Ensembl peptide - ENSP00000242285
Ensembl peptide - ENSP00000379848
Ensembl peptide - ENSP00000401019
Ensembl peptide - ENSP00000417698
Ensembl peptide - ENSP00000419158
Ensembl peptide - ENSP00000419746
NCBI entrez gene - 1211     See in Manteia.
OMIM - 118960
RefSeq - XM_017014258
RefSeq - NM_001076677
RefSeq - NM_001184760
RefSeq - NM_001184761
RefSeq - NM_001184762
RefSeq - NM_001311203
RefSeq - NM_001311204
RefSeq - NM_001311205
RefSeq - NM_001311206
RefSeq - NM_001833
RefSeq - NM_007096
RefSeq - XM_017014257
RefSeq Peptide - NP_001070145
RefSeq Peptide - NP_001171689
RefSeq Peptide - NP_001171690
RefSeq Peptide - NP_001298134
RefSeq Peptide - NP_001298135
RefSeq Peptide - NP_001824
RefSeq Peptide - NP_009027
RefSeq Peptide - NP_001171691
RefSeq Peptide - NP_001298132
RefSeq Peptide - NP_001298133
swissprot - F8WF69
swissprot - C9J8P9
swissprot - P09496
swissprot - S4R3F6
Ensembl - ENSG00000122705
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cltaENSDARG00000045618Danio rerio
 CLTAENSGALG00000015326Gallus gallus
 CltaENSMUSG00000028478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLTB / P09497 / clathrin light chain BENSG0000017541655


Protein motifs (from Interpro)
Interpro ID Name
 IPR000996  Clathrin light chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0032802 low-density lipoprotein particle receptor catabolic process TAS
 biological_processGO:0034383 low-density lipoprotein particle clearance TAS
 biological_processGO:0048268 clathrin coat assembly IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0072583 clathrin-dependent endocytosis IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030118 clathrin coat NAS
 cellular_componentGO:0030125 clathrin vesicle coat IBA
 cellular_componentGO:0030130 clathrin coat of trans-Golgi network vesicle IEA
 cellular_componentGO:0030132 clathrin coat of coated pit IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0036020 endolysosome membrane TAS
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle NAS
 cellular_componentGO:0071439 clathrin complex IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005198 structural molecule activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032050 clathrin heavy chain binding IPI
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
Entry of Influenza Virion into Host Cell via Endocytosis
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Lysosome Vesicle Biogenesis
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / complex / reaction
 ENSG00000100246 DNAL4 / O96015 / dynein axonemal light chain 4  / reaction
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / complex
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / complex / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex / reaction
 ENSG00000130164 LDLR / P01130 / low density lipoprotein receptor  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000169174 PCSK9 / Q8NBP7 / proprotein convertase subtilisin/kexin type 9  / complex / reaction
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex / reaction
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex / reaction
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / complex / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex / reaction
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex / reaction
 ENSG00000147852 VLDLR / P98155 / very low density lipoprotein receptor  / complex / reaction
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / complex / reaction
 ENSG00000129354 AP1M2 / Q9Y6Q5 / adaptor related protein complex 1 mu 2 subunit  / complex
 ENSG00000175416 CLTB / P09497 / clathrin light chain B  / complex
 ENSG00000072958 AP1M1 / Q9BXS5 / adaptor related protein complex 1 mu 1 subunit  / complex
 ENSG00000166747 AP1G1 / O43747 / adaptor related protein complex 1 gamma 1 subunit  / complex
 ENSG00000152056 AP1S3 / Q96PC3 / adaptor related protein complex 1 sigma 3 subunit  / complex
 ENSG00000182287 AP1S2 / P56377 / adaptor related protein complex 1 sigma 2 subunit  / complex
 ENSG00000100280 AP1B1 / Q10567 / adaptor related protein complex 1 beta 1 subunit  / complex
 ENSG00000106367 AP1S1 / P61966 / adaptor related protein complex 1 sigma 1 subunit  / complex
 ENSG00000090889 KIF4A / O95239 / kinesin family member 4A  / complex / reaction
 ENSG00000070371 CLTCL1 / P53675 / clathrin heavy chain like 1  / complex
 ENSG00000226650 KIF4B / Q2VIQ3 / kinesin family member 4B  / complex / reaction






 

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