ENSG00000109971


Homo sapiens

Features
Gene ID: ENSG00000109971
  
Biological name :HSPA8
  
Synonyms : heat shock protein family A (Hsp70) member 8 / HSPA8 / P11142
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q24.1
Gene start: 123057489
Gene end: 123063230
  
Corresponding Affymetrix probe sets: 208687_x_at (Human Genome U133 Plus 2.0 Array)   210338_s_at (Human Genome U133 Plus 2.0 Array)   221891_x_at (Human Genome U133 Plus 2.0 Array)   224187_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431641
Ensembl peptide - ENSP00000437189
Ensembl peptide - ENSP00000437125
Ensembl peptide - ENSP00000436762
Ensembl peptide - ENSP00000436183
Ensembl peptide - ENSP00000435908
Ensembl peptide - ENSP00000435154
Ensembl peptide - ENSP00000435019
Ensembl peptide - ENSP00000434851
Ensembl peptide - ENSP00000434565
Ensembl peptide - ENSP00000434415
Ensembl peptide - ENSP00000433584
Ensembl peptide - ENSP00000433316
Ensembl peptide - ENSP00000432884
Ensembl peptide - ENSP00000432083
Ensembl peptide - ENSP00000227378
Ensembl peptide - ENSP00000404372
NCBI entrez gene - 3312     See in Manteia.
OMIM - 600816
RefSeq - NM_153201
RefSeq - NM_006597
RefSeq - XM_011542798
RefSeq Peptide - NP_006588
RefSeq Peptide - NP_694881
swissprot - E9PN25
swissprot - E9PM13
swissprot - E9PLF4
swissprot - E9PKE3
swissprot - E9PS65
swissprot - E9PI65
swissprot - A8K7Q2
swissprot - P11142
swissprot - V9HW22
swissprot - E9PK54
swissprot - E9PQQ4
swissprot - E9PQK7
swissprot - E9PPY6
swissprot - E9PNE6
swissprot - E9PN89
Ensembl - ENSG00000109971
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspa8ENSDARG00000068992Danio rerio
 si:dkey-4p15.3ENSDARG00000037403Danio rerio
 HSPA8ENSGALG00000006512Gallus gallus
 Hspa8ENSMUSG00000015656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSPA2 / P54652 / heat shock protein family A (Hsp70) member 2ENSG0000012680386
HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1BENSG0000020438885
HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1AENSG0000020438985
HSPA1L / P34931 / heat shock protein family A (Hsp70) member 1 likeENSG0000020439083
HSPA6 / P17066 / heat shock protein family A (Hsp70) member 6ENSG0000017311078
HSPA5 / P11021 / heat shock protein family A (Hsp70) member 5ENSG0000004457464
HSPA14 / Q0VDF9 / heat shock protein family A (Hsp70) member 14ENSG0000018752226
HSPA14 / heat shock protein family A (Hsp70) member 14ENSG000002840247


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006457 protein folding NAS
 biological_processGO:0006479 protein methylation TAS
 biological_processGO:0006986 response to unfolded protein NAS
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0009267 cellular response to starvation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0042026 protein refolding IDA
 biological_processGO:0043254 regulation of protein complex assembly TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0044788 modulation by host of viral process IEA
 biological_processGO:0044829 positive regulation by host of viral genome replication IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0046034 ATP metabolic process IDA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0061635 regulation of protein complex stability ISS
 biological_processGO:0061684 chaperone-mediated autophagy TAS
 biological_processGO:0061738 late endosomal microautophagy IEA
 biological_processGO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy TAS
 biological_processGO:0061741 chaperone-mediated protein transport involved in chaperone-mediated autophagy NAS
 biological_processGO:0072318 clathrin coat disassembly IEA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1902904 negative regulation of supramolecular fiber organization IDA
 biological_processGO:1904589 regulation of protein import TAS
 biological_processGO:1904764 chaperone-mediated autophagy translocation complex disassembly ISS
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0000974 Prp19 complex IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005622 intracellular TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane ISS
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
 cellular_componentGO:0070062 extracellular exosome IDA
 cellular_componentGO:0072562 blood microparticle HDA
 cellular_componentGO:0098575 lumenal side of lysosomal membrane TAS
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0023026 MHC class II protein complex binding HDA
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042623 ATPase activity, coupled TAS
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051082 unfolded protein binding IDA
 molecular_functionGO:0055131 C3HC4-type RING finger domain binding IPI


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / complex / reaction
 ENSG00000004478 FKBP4 / Q02790 / FK506 binding protein 4  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex
 ENSG00000132002 DNAJB1 / P25685 / DnaJ heat shock protein family (Hsp40) member B1  / complex
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / reaction
 ENSG00000175416 CLTB / P09497 / clathrin light chain B  / complex
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex / reaction
 ENSG00000096060 FKBP5 / Q13451 / FK506 binding protein 5  / complex / reaction
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / complex / reaction
 ENSG00000070371 CLTCL1 / P53675 / clathrin heavy chain like 1  / complex
 ENSG00000116675 DNAJC6 / O75061 / DnaJ heat shock protein family (Hsp40) member C6  / complex
 ENSG00000134121 CHL1 / O00533 / cell adhesion molecule L1 like  / complex / reaction
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction
 ENSG00000144401 Q8WXB1 / METTL21A / methyltransferase like 21A  / reaction
 ENSG00000069345 DNAJA2 / O60884 / DnaJ heat shock protein family (Hsp40) member A2  / complex / reaction
 ENSG00000086061 DNAJA1 / P31689 / DnaJ heat shock protein family (Hsp40) member A1  / complex / reaction
 ENSG00000140403 DNAJA4 / Q8WW22 / DnaJ heat shock protein family (Hsp40) member A4  / complex / reaction






 

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