ENSG00000096384


Homo sapiens

Features
Gene ID: ENSG00000096384
  
Biological name :HSP90AB1
  
Synonyms : heat shock protein 90 alpha family class B member 1 / HSP90AB1 / P08238
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.1
Gene start: 44246166
Gene end: 44253888
  
Corresponding Affymetrix probe sets: 1557910_at (Human Genome U133 Plus 2.0 Array)   200064_at (Human Genome U133 Plus 2.0 Array)   214359_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481908
Ensembl peptide - ENSP00000325875
Ensembl peptide - ENSP00000360609
Ensembl peptide - ENSP00000360709
NCBI entrez gene - 3326     See in Manteia.
OMIM - 140572
RefSeq - NM_001271971
RefSeq - NM_001271969
RefSeq - NM_001271970
RefSeq - NM_001271972
RefSeq - NM_007355
RefSeq Peptide - NP_001258900
RefSeq Peptide - NP_001258898
RefSeq Peptide - NP_001258899
RefSeq Peptide - NP_001258901
RefSeq Peptide - NP_031381
swissprot - P08238
swissprot - A0A024RD80
Ensembl - ENSG00000096384
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HSP90AB1ENSGALG00000010175Gallus gallus
 P11499ENSMUSG00000023944Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1ENSG0000008082487
P14625 / HSP90B1 / heat shock protein 90 beta family member 1ENSG0000016659847
TRAP1 / Q12931 / TNF receptor associated protein 1ENSG0000012660229


Protein motifs (from Interpro)
Interpro ID Name
 IPR001404  Heat shock protein Hsp90 family
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR019805  Heat shock protein Hsp90, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR020575  Heat shock protein Hsp90, N-terminal
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily
 IPR037196  HSP90, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0006986 response to unfolded protein NAS
 biological_processGO:0007004 telomere maintenance via telomerase IDA
 biological_processGO:0009651 response to salt stress IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0019062 virion attachment to host cell IMP
 biological_processGO:0021955 central nervous system neuron axonogenesis IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0031396 regulation of protein ubiquitination IDA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISS
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0050821 protein stabilization TAS
 biological_processGO:0051131 chaperone-mediated protein complex assembly IDA
 biological_processGO:0051248 negative regulation of protein metabolic process ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0051973 positive regulation of telomerase activity IDA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway IMP
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0071157 negative regulation of cell cycle arrest IMP
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0097435 supramolecular fiber organization IMP
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1901389 negative regulation of transforming growth factor beta activation IDA
 biological_processGO:1901799 negative regulation of proteasomal protein catabolic process ISS
 biological_processGO:1902949 positive regulation of tau-protein kinase activity IC
 biological_processGO:1903660 negative regulation of complement-dependent cytotoxicity IEA
 biological_processGO:1904031 positive regulation of cyclin-dependent protein kinase activity ISS
 biological_processGO:1905323 telomerase holoenzyme complex assembly IDA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion HDA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008180 COP9 signalosome IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0034751 aryl hydrocarbon receptor complex IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044294 dendritic growth cone IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 cellular_componentGO:1990913 sperm head plasma membrane IEA
 cellular_componentGO:1990917 ooplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002134 UTP binding IEA
 molecular_functionGO:0002135 CTP binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IMP
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0017098 sulfonylurea receptor binding IEA
 molecular_functionGO:0019887 protein kinase regulator activity IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0023026 MHC class II protein complex binding HDA
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity ISS
 molecular_functionGO:0030911 TPR domain binding ISS
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0032564 dATP binding IEA
 molecular_functionGO:0042277 peptide binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043008 ATP-dependent protein binding IPI
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046983 protein dimerization activity IDA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IPI
 molecular_functionGO:0097718 disordered domain specific binding IPI
 molecular_functionGO:1990226 histone methyltransferase binding IPI


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Sema3A PAK dependent Axon repulsion
Uptake and function of diphtheria toxin
Neutrophil degranulation
The NLRP3 inflammasome
The role of GTSE1 in G2/M progression after G2 checkpoint
Aryl hydrocarbon receptor signalling
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004478 FKBP4 / Q02790 / FK506 binding protein 4  / complex / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / complex / reaction
 ENSG00000106546 AHR / P35869 / aryl hydrocarbon receptor  / complex
 ENSG00000113580 NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1  / complex
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / complex / reaction
 ENSG00000082175 PGR / P06401 / progesterone receptor  / complex
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / complex / reaction
 ENSG00000165416 SUGT1 / Q9Y2Z0 / SGT1 homolog, MIS12 kinetochore complex assembly cochaperone  / - / complex / reaction
 ENSG00000110711 AIP / O00170 / aryl hydrocarbon receptor interacting protein  / complex
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / complex / reaction
 ENSG00000171497 PPID / Q08752 / peptidylprolyl isomerase D  / complex
 ENSG00000069345 DNAJA2 / O60884 / DnaJ heat shock protein family (Hsp40) member A2  / reaction
 ENSG00000162711 NLRP3 / Q96P20 / NLR family pyrin domain containing 3  / - / complex / reaction
 ENSG00000086061 DNAJA1 / P31689 / DnaJ heat shock protein family (Hsp40) member A1  / reaction
 ENSG00000106683 LIMK1 / P53667 / LIM domain kinase 1  / complex / reaction
 ENSG00000151623 NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2  / complex
 ENSG00000140403 DNAJA4 / Q8WW22 / DnaJ heat shock protein family (Hsp40) member A4  / reaction
 ENSG00000142192 APP / P05067 / amyloid beta precursor protein  / - / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex
 ENSG00000103490 PYCARD / Q9ULZ3 / PYD and CARD domain containing  / complex / reaction
 ENSG00000140009 ESR2 / Q92731 / estrogen receptor 2  / complex
 ENSG00000137752 CASP1 / P29466 / caspase 1  / complex / reaction
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / - / complex
 ENSG00000096060 FKBP5 / Q13451 / FK506 binding protein 5  / complex / reaction
 ENSG00000169083 AR / P10275 / androgen receptor  / complex
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / complex / reaction
 ENSG00000204315 FKBPL / Q9UIM3 / FK506 binding protein like  / complex / reaction
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / complex / reaction
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / complex / reaction
 ENSG00000075218 GTSE1 / Q9NYZ3 / G2 and S-phase expressed 1  / complex / reaction






 

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