ENSMUSG00000023944


Mus musculus

Features
Gene ID: ENSMUSG00000023944
  
Biological name :Hsp90ab1
  
Synonyms : Heat shock protein HSP 90-beta / Hsp90ab1 / P11499
  
Possible biological names infered from orthology : heat shock protein 90 alpha family class B member 1 / P08238
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B3
Gene start: 45567775
Gene end: 45573271
  
Corresponding Affymetrix probe sets: 10451110 (MoGene1.0st)   1416364_at (Mouse Genome 430 2.0 Array)   1416365_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024739
Ensembl peptide - ENSMUSP00000131601
Ensembl peptide - ENSMUSP00000127338
Ensembl peptide - ENSMUSP00000126239
Ensembl peptide - ENSMUSP00000119678
NCBI entrez gene - 15516     See in Manteia.
MGI - MGI:96247
RefSeq - NM_008302
RefSeq Peptide - NP_032328
swissprot - D3Z1R1
swissprot - P11499
swissprot - E9Q3D6
swissprot - Q71LX8
swissprot - E9Q0C3
swissprot - E9PX27
Ensembl - ENSMUSG00000023944
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HSP90AB1ENSGALG00000010175Gallus gallus
 P08238ENSG00000096384Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*ENSMUSG0000002127087
P08113 / Hsp90b1 / heat shock protein 90, beta (Grp94), member 1 / P14625* / heat shock protein 90 beta family member 1*ENSMUSG0000002004846
Trap1 / Q9CQN1 / Heat shock protein 75 kDa, mitochondrial / Q12931* / TNF receptor associated protein 1*ENSMUSG0000000598128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001404  Heat shock protein Hsp90 family
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR019805  Heat shock protein Hsp90, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR020575  Heat shock protein Hsp90, N-terminal
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily
 IPR037196  HSP90, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0007004 telomere maintenance via telomerase IEA
 biological_processGO:0009651 response to salt stress IEA
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0019062 virion attachment to host cell IEA
 biological_processGO:0021955 central nervous system neuron axonogenesis IMP
 biological_processGO:0030010 establishment of cell polarity IEP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISS
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0051131 chaperone-mediated protein complex assembly IEA
 biological_processGO:0051248 negative regulation of protein metabolic process IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0097435 supramolecular fiber organization IEA
 biological_processGO:1901389 negative regulation of transforming growth factor beta activation IEA
 biological_processGO:1901799 negative regulation of proteasomal protein catabolic process IMP
 biological_processGO:1903660 negative regulation of complement-dependent cytotoxicity IEA
 biological_processGO:1904031 positive regulation of cyclin-dependent protein kinase activity IMP
 biological_processGO:1905323 telomerase holoenzyme complex assembly IEA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0034751 aryl hydrocarbon receptor complex IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0044294 dendritic growth cone IDA
 cellular_componentGO:0044295 axonal growth cone IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:1990913 sperm head plasma membrane IEA
 cellular_componentGO:1990917 ooplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002134 UTP binding IEA
 molecular_functionGO:0002135 CTP binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0017098 sulfonylurea receptor binding IEA
 molecular_functionGO:0019887 protein kinase regulator activity IMP
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity ISS
 molecular_functionGO:0030911 TPR domain binding ISS
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0032564 dATP binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043008 ATP-dependent protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0048156 tau protein binding IPI
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA
 molecular_functionGO:1990226 histone methyltransferase binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Sema3A PAK dependent Axon repulsion
Neutrophil degranulation
The NLRP3 inflammasome
The role of GTSE1 in G2/M progression after G2 checkpoint
Aryl hydrocarbon receptor signalling
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015656 Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*  / complex / reaction
 ENSMUSG00000029674 Limk1 / P53668 / LIM domain kinase 1 / P53667*  / complex / reaction
 ENSMUSG00000024847 Aip / O08915 / AH receptor-interacting protein / O00170* / aryl hydrocarbon receptor interacting protein*  / complex
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex
 ENSMUSG00000024966 Stip1 / Q60864 / Stress-induced-phosphoprotein 1 / P31948*  / complex / reaction
 ENSMUSG00000030357 Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*  / complex / reaction
 ENSMUSG00000033739 Fkbpl / O35450 / FK506-binding protein-like / Q9UIM3*  / complex / reaction
 ENSMUSG00000028410 Dnaja1 / P63037 / DnaJ homolog subfamily A member 1 / P31689* / DnaJ heat shock protein family (Hsp40) member A1*  / reaction
 ENSMUSG00000031701 Dnaja2 / Q9QYJ0 / DnaJ homolog subfamily A member 2 / O60884* / DnaJ heat shock protein family (Hsp40) member A2*  / reaction
 ENSMUSG00000022024 Sugt1 / Q9CX34 / SGT1 homolog, MIS12 kinetochore complex assembly cochaperone / Q9Y2Z0*  / complex / reaction
 ENSMUSG00000032285 Dnaja4 / Q9JMC3 / Mus musculus DnaJ heat shock protein family (Hsp40) member A4 (Dnaja4), transcript variant 1, mRNA. / Q8WW22* / DnaJ heat shock protein family (Hsp40) member A4*  / reaction
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / complex / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / complex
 ENSMUSG00000031870 Pgr / Q00175 / Progesterone receptor / P06401*  / complex
 ENSMUSG00000091971 Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / complex / reaction
 ENSMUSG00000032691 Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*  / complex / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / complex / reaction
 ENSMUSG00000019256 Ahr / aryl hydrocarbon receptor isoform 2 / P35869* / AC019117.3* / aryl hydrocarbon receptor*  / complex
 ENSMUSG00000090877 P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / complex / reaction
 ENSMUSG00000022385 Gtse1 / Q8R080 / G2 and S phase-expressed protein 1 / Q9NYZ3* / G2 and S-phase expressed 1*  / complex / reaction
 ENSMUSG00000027804 Ppid / Q9CR16 / peptidylprolyl isomerase D (cyclophilin D) / Q08752* / peptidylprolyl isomerase D*  / complex
 ENSMUSG00000021055 Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*  / complex
 ENSMUSG00000024222 Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*  / complex / reaction






 

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