ENSGALG00000010175


Gallus gallus

Features
Gene ID: ENSGALG00000010175
  
Biological name :HSP90AB1
  
Synonyms : heat shock cognate protein HSP 90-beta / HSP90AB1
  
Possible biological names infered from orthology : heat shock protein 90 alpha family class B member 1 / Heat shock protein HSP 90-beta / P08238 / P11499
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 30356759
Gene end: 30362595
  
Corresponding Affymetrix probe sets: Gga.4332.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052203
Ensembl peptide - ENSGALP00000059568
Ensembl peptide - ENSGALP00000059437
Ensembl peptide - ENSGALP00000059230
Ensembl peptide - ENSGALP00000016523
NCBI entrez gene - 396188     See in Manteia.
RefSeq - NM_206959
RefSeq - XM_015283624
RefSeq Peptide - NP_996842
swissprot - A0A1L1RLE5
swissprot - F1NC33
swissprot - A0A1L1RL18
swissprot - A0A1D5PHC5
Ensembl - ENSGALG00000010175
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P08238ENSG00000096384Homo sapiens
 P11499ENSMUSG00000023944Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSP90AA1 / heat shock protein HSP 90-alpha / P07900* / P07901* / heat shock protein 90 alpha family class A member 1*ENSGALG0000003321287
HSP90B1 / endoplasmin precursor / P14625* / P08113* / heat shock protein 90 beta family member 1* / heat shock protein 90, beta (Grp94), member 1*ENSGALG0000003378946
TRAP1 / TNF receptor associated protein 1 / Q12931* / Q9CQN1* / Heat shock protein 75 kDa, mitochondrial *ENSGALG0000003995128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001404  Heat shock protein Hsp90 family
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR019805  Heat shock protein Hsp90, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR020575  Heat shock protein Hsp90, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0007004 telomere maintenance via telomerase IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0019062 virion attachment to host cell IEA
 biological_processGO:0021955 central nervous system neuron axonogenesis IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0051131 chaperone-mediated protein complex assembly IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:0097435 supramolecular fiber organization IEA
 biological_processGO:1901389 negative regulation of transforming growth factor beta activation IEA
 biological_processGO:1901799 negative regulation of proteasomal protein catabolic process IEA
 biological_processGO:1904031 positive regulation of cyclin-dependent protein kinase activity IEA
 biological_processGO:1905323 telomerase holoenzyme complex assembly IEA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0034751 aryl hydrocarbon receptor complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044294 dendritic growth cone IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019887 protein kinase regulator activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043008 ATP-dependent protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA
 molecular_functionGO:1990226 histone methyltransferase binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Sema3A PAK dependent Axon repulsion
Neutrophil degranulation
The NLRP3 inflammasome
Aryl hydrocarbon receptor signalling
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014331 FKBP4 / peptidyl-prolyl cis-trans isomerase FKBP4 / P30416* / Q02790* / FK506 binding protein 4* / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-te...  / complex / reaction
 ENSGALG00000010035 NR3C2 / mineralocorticoid receptor / P08235* / nuclear receptor subfamily 3 group C member 2*  / complex
 ENSGALG00000004115 DNAJA2 / DnaJ heat shock protein family (Hsp40) member A2 / O60884* / Q9QYJ0* / DnaJ homolog subfamily A member 2 *  / reaction
 ENSGALG00000010836 AHR / P35869* / AC019117.3* / aryl hydrocarbon receptor* / aryl hydrocarbon receptor isoform 2 *  / complex
 ENSGALG00000010175 HSP90AB1 / heat shock cognate protein HSP 90-beta / P08238* / P11499* / Heat shock protein HSP 90-beta * / heat shock protein 90 alpha family class B member 1*  / complex
 ENSGALG00000036837 PTGES3 / prostaglandin E synthase 3 / Q15185* / Q9R0Q7*  / complex / reaction
 ENSGALG00000016946 SUGT1 / SGT1 homolog, MIS12 kinetochore complex assembly cochaperone / Q9CX34* / Q9Y2Z0*  / complex / reaction
 ENSGALG00000023066 DNAJA1 / DnaJ heat shock protein family (Hsp40) member A1 / P31689* / P63037* / DnaJ homolog subfamily A member 1 *  / reaction
 ENSGALG00000032992 NR3C1 / glucocorticoid receptor / P04150* / nuclear receptor subfamily 3 group C member 1*  / complex
 ENSGALG00000040247 AIP / aryl hydrocarbon receptor interacting protein / O00170* / O08915* / AH receptor-interacting protein *  / complex
 ENSGALG00000042148 FKBP5 / peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / Q64378* / FK506 binding protein 5*  / complex / reaction
 ENSGALG00000009451 PPID / peptidylprolyl isomerase D / Q08752* / Q9CR16* / peptidylprolyl isomerase D (cyclophilin D)*  / complex
 ENSGALG00000001076 LIMK1 / Q8QFP8 / LIM domain kinase 1 / P53667* / P53668*  / complex / reaction






 

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