ENSMUSG00000019768


Mus musculus

Features
Gene ID: ENSMUSG00000019768
  
Biological name :Esr1
  
Synonyms : Esr1 / Estrogen receptor / P19785
  
Possible biological names infered from orthology : estrogen receptor 1 / P03372
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A1
Gene start: 4611593
Gene end: 5005614
  
Corresponding Affymetrix probe sets: 10367600 (MoGene1.0st)   1421244_at (Mouse Genome 430 2.0 Array)   1435663_at (Mouse Genome 430 2.0 Array)   1460591_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101215
Ensembl peptide - ENSMUSP00000070070
Ensembl peptide - ENSMUSP00000101213
Ensembl peptide - ENSMUSP00000101214
NCBI entrez gene - 13982     See in Manteia.
MGI - MGI:1352467
RefSeq - XM_011243068
RefSeq - NM_001302533
RefSeq - NM_007956
RefSeq - XM_006512433
RefSeq - XM_006512434
RefSeq - XM_006512435
RefSeq - XM_011243066
RefSeq - XM_011243067
RefSeq - NM_001302531
RefSeq - NM_001302532
RefSeq Peptide - NP_031982
RefSeq Peptide - NP_001289460
RefSeq Peptide - NP_001289461
RefSeq Peptide - NP_001289462
swissprot - P19785
swissprot - E7FJU2
swissprot - D3Z6V3
Ensembl - ENSMUSG00000019768
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esr1ENSDARG00000004111Danio rerio
 ESR1ENSGALG00000012973Gallus gallus
 ESR1ENSG00000091831Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*ENSMUSG0000002105542
Esrrg / P62509 / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA. / P62508* / estrogen related receptor gamma*ENSMUSG0000002661027
Esrrb / Q61539 / Steroid hormone receptor ERR2 / O95718* / estrogen related receptor beta*ENSMUSG0000002125525
Esrra / O08580 / Steroid hormone receptor ERR1 / P11474* / estrogen related receptor alpha*ENSMUSG0000002495524
Nr3c2 / nuclear receptor subfamily 3 group C member 2 / P08235*ENSMUSG0000003161821
Nr4a1 / P12813 / nuclear receptor subfamily 4, group A, member 1 / P22736*ENSMUSG0000002303420
Nr3c1 / nuclear receptor subfamily 3, group C, member 1 / P04150*ENSMUSG0000002443120
Nr4a2 / Q06219 / Nuclear receptor subfamily 4 group A member 2 / P43354*ENSMUSG0000002682620
Pgr / Q00175 / Progesterone receptor / P06401*ENSMUSG0000003187020
Ar / P19091 / Androgen receptor / P10275*ENSMUSG0000004653219
Nr4a3 / Q9QZB6 / Nuclear receptor subfamily 4 group A member 3 / Q92570*ENSMUSG0000002834118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001292  Oestrogen receptor
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR024178  Oestrogen receptor/oestrogen-related receptor
 IPR024736  Oestrogen-type nuclear receptor final C-terminal domain
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001547 antral ovarian follicle growth IMP
 biological_processGO:0002064 epithelial cell development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II ISO
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0008209 androgen metabolic process IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010863 positive regulation of phospholipase C activity ISS
 biological_processGO:0016049 cell growth NAS
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway ISS
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway ISO
 biological_processGO:0032355 response to estradiol ISO
 biological_processGO:0034121 regulation of toll-like receptor signaling pathway IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0043627 response to estrogen ISO
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISS
 biological_processGO:0045839 negative regulation of mitotic nuclear division NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048863 stem cell differentiation IDA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity ISS
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0060065 uterus development IGI
 biological_processGO:0060068 vagina development IGI
 biological_processGO:0060523 prostate epithelial cord elongation IMP
 biological_processGO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IMP
 biological_processGO:0060745 mammary gland branching involved in pregnancy IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IMP
 biological_processGO:0071168 protein localization to chromatin ISO
 biological_processGO:0071391 cellular response to estrogen stimulus IMP
 biological_processGO:0071392 cellular response to estradiol stimulus ISS
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035327 transcriptionally active chromatin ISO
 cellular_componentGO:0097550 transcriptional preinitiation complex ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001093 TFIIB-class transcription factor binding ISO
 molecular_functionGO:0001223 transcription coactivator binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0005496 steroid binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0017025 TBP-class protein binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030284 estrogen receptor activity ISO
 molecular_functionGO:0030331 estrogen receptor binding ISO
 molecular_functionGO:0034056 estrogen response element binding ISO
 molecular_functionGO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051117 ATPase binding ISO


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
RUNX1 regulates estrogen receptor mediated transcription
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm1Ksk/Esr1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: B6.129P2-Apoetm1Bres

 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
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Allelic Composition: Esr1tm1Sakh/Esr1tm1Sakh,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm2.1Gsc/Esr1tm2.1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Esr1tm1Sakh/Esr1tm1Sakh,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Esr1tm1Sakh/Esr1tm1Sakh,Tg(Wap-cre)11738Mam/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Wnt7a-EGFP/cre)#Bhr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001121 uterine hypoplasia "reduced size of the uterus due to decreased cell number" [J:45065]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

 MP:0001123 dilated uterus "stretched or enlarged female muscular organ of gestation" [J:50844]
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Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inha+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
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Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0001139 abnormal vagina morphology "malformation of the female reproductive canal located between the uterus and the vulva" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001140 abnormal vaginal epithelium "malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk/J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: MaoaK284stop/Y
Genetic Background: 129S6/SvEvTac-MaoaK284stop

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

 MP:0001356 increased aggression towards females "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward female mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

 MP:0001376 abnormal mating receptivity "deviation from the normal cycle or inability of females to respond favorably to males that initiate sexual behavior" [J:51468]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal
Genetic Background: involves: C57BL/6

Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm2Ksk/Esr1tm2Ksk
Genetic Background: involves: C57BL/6

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal
Genetic Background: involves: C57BL/6

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Esr1tm1Sakh/Esr1tm1Sakh,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0001884 mammary alveolar hyperplasia 
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0001885 mammary ductal hyperplasia 
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1Hdlq1-129S1/SvImJ/?
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Esr1tm1.1Mma/Esr1+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal
Genetic Background: involves: C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm2.1Gsc/Esr1tm2.1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
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Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr1tm4Bet/Gabbr1tm4Bet
Genetic Background: BALB/c-Gabbr1tm4Bet

Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: am/a
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrxn1tm5Sud/Nrxn1tm5Sud
Genetic Background: involves: C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal
Genetic Background: involves: C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm2.1Gsc/Esr1tm2.1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk/J

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal
Genetic Background: involves: C57BL/6

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0003357 impaired granulosa cell differentiation "atypical differentiation of the layer of small cells that forms the wall of an ovarian follicle" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43075]
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Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003572 abnormal uterus development "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal
Genetic Background: involves: C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003863 decreased aggression towards mice "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

 MP:0003969 abnormal lutenizing hormone level 
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Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004348 long femur "increased length of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004728 abnormal efferent ductules of testis "any structural abnormality in the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004834 ovary hemorrhage "presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm2.1Gsc/Esr1tm2.1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004850 abnormal testis weight "anomaly in the average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: am/a
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0004894 uterus atrophy "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Apoetm1Bres Esr1tm1Ksk

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004902 abnormal uterus size "anomaly in the size of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Wnt7a-EGFP/cre)#Bhr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004903 abnormal uterus weight "anomaly in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004906 enlarged uterus 
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal
Genetic Background: involves: C57BL/6

Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0005133 increased luteinizing hormone level "higher than normal levels of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal
Genetic Background: involves: C57BL/6

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Apoetm1Bres Esr1tm1Ksk

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal
Genetic Background: involves: C57BL/6

Allelic Composition: Esr1tm1Arnal/Esr1tm1Arnal,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Apoetm1Bres Esr1tm1Ksk

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic Background: B6.129X1-Esr1tm1.1Gust

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005646 abnormal pituitary gland physiology "anmalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0006416 abnormal rete testis morphology "any structural anomaly of the network of canals at the termination of the straight tubules in the mediastinum testis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0006423 dilated rete testis "an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid" [J:121125, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inha+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008256 abnormal myometrium morphology "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0008332 decreased lactotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0008334 increased gonadotroph cell number "greater number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008335 decreased gonadotroph cell number "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Tg(Cga-cre)1Awo/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008487 abnormal mesonephros morphology "any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop" [MESH:A16.254.500]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008737 abnormal spleen physiology "any anomaly in the function of the organ that filters blood and stores red corpuscles and platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008868 abnormal granulosa cell morphology "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
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Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008983 small vagina "decrease in the size of the female reproductive canal located between the uterus and the vulva" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008984 vagina hypoplasia "underdevelopment or reduced size of the vagina, usually due to a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0008994 early vaginal opening "the opening of the genital canal in a female occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009081 thin uterus "reduced thickness or depth of the female muscular organ of gestation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0009093 oocyte degeneration "a retrogressive impairment of function or destruction of the female germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009096 decreased endometrial gland number "fewer than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009097 absent endometrial glands "absence of the simple or branched tubular uterine glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0009130 increased white fat cell number "increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0009140 dilated efferent ductules of testis "an expansion in the volume or area of the lumen of the small seminal ducts that lead from the testis to the head of the epididymis, usually with an increase in contained fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009205 abnormal internal male genitalia morphology "any structural anomaly of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009251 enlarged endometrial glands "increase in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0009257 dilated seminiferous tubules "the luminal space of the seminiferous tubules is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0009296 increased mammary fat pad weight 
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Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009300 increased parametrial fat pad weight 
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0009302 increased renal fat pad weight 
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009359 endometrium atrophy "wasting of the endometrium due to injury or disease resulting in reduced size" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0009362 abnormal primary ovarian follicle morphology "any structural abnormality in the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Esr1tm1.1Mma/Esr1+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009365 abnormal theca folliculi "any structural abnormality in the envelope of condensed connective tissue surrounding a secondary ovarian follicle; the theca folliculi are divided into two layers, an internal vascular layer (tunica interna) and an external fibrous layer (tunica externa)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Gsc/Esr1tm1Gsc,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009371 increased thecal cell number "greater than normal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Geog/Esr1tm1Geog
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009444 ovarian follicular cyst "a sac filled with fluid that may develop when the structure containing the egg fails to break open at the time of ovulation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Sakh/Esr1tm1Sakh,Tg(Wap-cre)11738Mam/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009662 abnormal uterine receptivity "any alteration in the time sensitive process of uterine differentiation that occurs in response to implantation competent blastocysts and precedes and is necessary for embryo implantation" [PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]
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Allelic Composition: Esr1tm1.2Mma/Esr1tm1.2Mma,Tg(Wnt7a-EGFP/cre)#Bhr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009671 abnormal uterus physiology "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Esr1tm1Ksk

 MP:0009736 abnormal prostate gland branching morphogenesis "anomaly of the prostatic bud to repeatedly divide into lobules during development of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009824 spermatic granuloma "a granulomatous nodular lesion that appears in the region of epididymis and can be large enough to totally occlude the epididymal lumen; sperm granulomas are rounded or irregular in shape, and contain dense aggregates of immune cells and degenerating sperm resulting from an autoimmune response against sperm-associated antigens exposed following biochemical or surgical insult (e.g. vasectomy) to the epididymal epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0009856 failure of ejaculation "inability to propulse semen from the genital ducts and the urethra to the exterior within a defined test period" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Syeh/Esr1tm1Syeh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0010962 decreased compact bone mass 
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Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0010967 increased compact bone area "increase in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010968 decreased compact bone area "reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Esr2tm1Mma/Esr2tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011121 decreased primordial ovarian follicle number "fewer than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith]
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Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Esr1tm1.1Ics/Esr1tm1.1Ics
Genetic Background: involves: C57BL/6NTac

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011833 abnormal cremaster muscle morphology "any structural anomaly of the thin layer of skeletal muscle that envelops the spermatic cord and testis of most male mammals in a series of loops; it is a continuation of the obliquus internus, arising from the inguinal ligament and inserting into the crest of the pubis and into the sheath of the rectus abdominis; it is innervated by the genital branch of the genitofemoral nerve and functions to draw the testis up toward the superficial inguinal ring in response to cold or to stimulation of the nerve; in females it is represented by only a few muscle loops that envelop the round ligament of the uterus" [MGI:anna]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esr1tm1Ksk/Esr1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0013613 abnormal volumetric bone mineral density "anomaly of the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]
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Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0013615 increased volumetric bone mineral density "increase in the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013616 decreased volumetric bone mineral density "reduction in the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Esr1tm1.1Lja/Esr1tm1.1Mma
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0013618 decreased areal bone mineral density "reduction of the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]
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Allelic Composition: Esr1tm1.1Lja/Esr1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0013795 abnormal colon goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: ApcMin/Apc+,Esr1tm1.1Mma/Esr1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Fechtm1Dab/Fech+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002658 Gtf2f1 / Q3THK3 / ral transcription factor IIF subunit 1 / P35269* / general transcription factor IIF subunit 1*  / complex
 ENSMUSG00000009555 Cdk9 / Q99J95 / Cyclin-dependent kinase 9 / P50750*  / complex
 ENSMUSG00000011960 Ccnt1 / Q9QWV9 / Cyclin-T1 / O60563*  / complex
 ENSMUSG00000026398 Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*  / complex
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex
 ENSMUSG00000027804 Ppid / Q9CR16 / peptidylprolyl isomerase D (cyclophilin D) / Q08752* / peptidylprolyl isomerase D*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000022360 Atad2 / Q8CDM1 / ATPase family AAA domain-containing protein 2 / Q6PL18* / ATPase family, AAA domain containing 2*  / complex / reaction
 ENSMUSG00000109324 Prmt1 / Q9JIF0 / protein arginine N-methyltransferase 1 / Q99873* / protein arginine methyltransferase 1*  / complex / reaction
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / complex
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / complex / reaction
 ENSMUSG00000014767 Tbp / P29037 / TATA box binding protein / P20226*  / complex / reaction
 ENSMUSG00000022346 Myc / P01108 / myelocytomatosis oncogene / P01106* / MYC proto-oncogene, bHLH transcription factor*  / complex
 ENSMUSG00000024767 Otub1 / Q7TQI3 / Ubiquitin thioesterase OTUB1 / Q96FW1* / OTU deubiquitinase, ubiquitin aldehyde binding 1*  / complex / reaction
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / complex / reaction
 ENSMUSG00000021250 Fos / P01101 / Proto-onco c-Fos / P01100* / Fos proto-oncogene, AP-1 transcription factor subunit*  / complex
 ENSMUSG00000020962 Gtf2a1 / Q99PM3 / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiation factor IIA beta chain / P52655* / general transcript...  / complex / reaction
 ENSMUSG00000032185 Carm1 / Q9WVG6 / Histone-arginine methyltransferase CARM1 / Q86X55* / coactivator associated arginine methyltransferase 1*  / complex / reaction
 ENSMUSG00000027104 Atf2 / P16951 / Cyclic AMP-dependent transcription factor ATF-2 / P15336* / activating transcription factor 2*  / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000036523 Greb1 / Q3UHK3 / Protein GREB1 / Q4ZG55* / growth regulation by estrogen in breast cancer 1*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000036940 Kdm1a / Q6ZQ88 / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341* / lysine demethylase 1A*  / complex / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000051159 Cited1 / P97769 / Cbp/p300-interacting transactivator 1 / Q99966* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction
 ENSMUSG00000031870 Pgr / Q00175 / Progesterone receptor / P06401*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000052684 Jun / P05627 / jun proto-oncogene / P05412* / Jun proto-oncogene, AP-1 transcription factor subunit*  / complex
 ENSMUSG00000033543 Gtf2a2 / Q80ZM7 / Transcription initiation factor IIA subunit 2 / P52657* / general transcription factor IIA subunit 2*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / complex / reaction
 ENSMUSG00000052056 Zfp217 / zinc finger protein 217 / O75362* / ZNF217*  / complex
 ENSMUSG00000021055 Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*  / complex / reaction
 ENSMUSG00000027678 Ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / complex / reaction
 ENSMUSG00000020647 Ncoa1 / P70365 / Nuclear receptor coactivator 1 / Q15788*  / complex / reaction
 ENSMUSG00000067995 Gtf2f2 / Q8R0A0 / ral transcription factor IIF subunit 2 / P13984* / general transcription factor IIF subunit 2*  / complex






 

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